Endogenous Endophthalmitis in the Korean Population

Lim, Han Woong; Shin, Joong Won; Cho, Hee Yoon; Kim, Ha Kyoung; Kang, Se Woong; Song, Su Jeong; Yu, Hyeong Gon; Oh, Jaeryung; Kim, Jae Suk; Moon, Sang Woong; Chae, Ju Byung; Park, Tae Kwann; Song, Yumi

doi:10.1097/iae.0b013e3182a2e705

Cited by 90 publications

(82 citation statements)

References 29 publications

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“…Philips and Tasman16 found that gram-negative bacteria account for the higher prevalence of endophthalmitis in diabetics compared to non-diabetics and that gram-negative microorganisms result in a poorer endophthalmitis prognosis. In a study of endogenic endophthalmitis by Lim et al 17 including 53 patients, gram-negative bacteria were detected in 54.38% of cases. Klebsiella pneumoniae was the most common gram-negative bacterial isolate (45.61%) and diabetes was determined to be the most significant underlying risk factor.…”

Section: Discussionmentioning

confidence: 95%

Conjunctival Flora in Diabetic and Nondiabetic Individuals

Adam¹,

Balcı²,

Bayhan³

et al. 2015

tjo

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Objectives:To evaluate the conjunctival bacterial flora in diabetic patients and nondiabetic subjects.Materials and Methods:Fifty-three diabetic patients and 43 nondiabetic healthy individuals were included in the study. A specimen was taken from each participant for the study by rubbing a sterile cotton-tipped swab on the inferior palpebral conjunctiva of the right eye. Samples were incubated in blood agar, chocolate agar, eosin methylene-blue lactose sucrose agar and sabouraud 4% dextrose agar. Isolated microorganisms were identified using routine microbiological methods.Results:Rates for bacterial isolations were determined as 38.5% in diabetic patients and 34.9% in nondiabetic controls. Staphylococcus aureus was isolated in 30% of cases in the diabetic patient group, while 20% tested positive for Escherichia coli, 10% for coagulase-negative Staphylococcus, 10% for Klebsiella pneumoniae and 30% for multiple bacteria. In the non-diabetic group, 53.3% of patients were positive for Staphylococcus aureus while coagulase-negative Staphylococcus was isolated in 26.7%, Klebsiella pneumoniae in 6.7% and multiple bacteria in 13.3% of patients. Although there was no statistically significant difference in the number of isolated bacteria between the diabetic and nondiabetic groups, gram-negative bacterial colonization was significantly higher in diabetic patients (χ2=0.129, p=0.719 and χ2=5.60, p=0.018, respectively).Conclusion:Gram-negative bacteria are more common in the conjunctival flora of diabetic patients. This should be considered by clinicians when treating ocular infections in diabetic patients.

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Section: Discussionmentioning

confidence: 95%

Conjunctival Flora in Diabetic and Nondiabetic Individuals

Adam¹,

Balcı²,

Bayhan³

et al. 2015

tjo

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“…The major risk factor that contributes to endogenous endophthalmitis was immunocompromised state, including prolonged corticosteroid use, malignancy, end-stage renal or liver disease, post-organ transplant, and diabetes mellitus. Illicit intravenous drug use, indwelling catheter, or dental procedures were also reported as significant risk factors [4][5][6][7][8]. EE has been reported in healthy individuals in an extraordinary case [3].…”

Section: Discussionmentioning

confidence: 99%

“…Endogenous endophthalmitis (EE) is an ongoing diagnostic and therapeutic dilemma for ophthalmologists, as it is relatively rare, often presents like uveitis, and requires a high index of suspicion for prompt diagnosis and treatment [1,[3][4][5].…”

Section: Discussionmentioning

confidence: 99%

A Case of a Large Sub-retinal Abscess Secondary to Klebsiella pneumoniae Endophthalmitis in a Pyelonephritis Patient

Mohd-Ilham¹,

Zulkifli²,

Yaakub³

et al. 2019

Cureus

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Endogenous endophthalmitis is an ocular emergency, with severe sight-threatening complications. We report a case of unilateral endogenous Klebsiella pneumonia endophthalmitis with a large sub-retinal abscess in a 39-year-old lady that developed four days after presentation with sepsis secondary to urinary tract infections and pyelonephritis. Despite immediate treatment with intravenous (IV) and intravitreal antibiotics, her eye condition deteriorated. A pars plana vitrectomy was performed, and the sub-retinal abscess was removed, followed by silicone oil tamponade. Subsequently, she regained her vision to 6/36 with complete regression of the intraocular inflammation and sub-retinal abscess.

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“…Philips and Tasman found that gram-negative bacteria account for the higher prevalence of endophthalmitis in diabetics compared to non-diabetics and that gramnegative microorganisms result in a poorer endophthalmitis prognosis. In a study of endogenic endophthalmitis by Lim et al including 53 patients, gram-negative bacteria were detected in 54.38% of cases [19] Klebsiella pneumoniae was the most common gram-negative bacterial isolate (45.61%) and diabetes was determined to be the most significant underlying risk factor. Similarly, gram-negative agents are noteworthy in other infections in diabetics.…”

Section: Original Research Articlementioning

confidence: 97%

A study to compare the conjunctival flora of non-diabetic individuals with that of diabetic patients

Rajeshkannan¹,

Venkatesan²,

Ezhilvendhan³

et al. 2019

Trop J Ophthalmol Otolaryngol

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Background: The conjunctiva is a thin, transparent and humid membrane which covers the sclera and inner surface of eyelids. The tears film helps to moist the conjunctiva. In a healthy person, surface tissues such as skin and mucous membranes are constantly in contact with environmental organisms and become colonised by various microorganisms , bacteria and fungi which are referred to as normal flora. Aim: To compare the conjunctival flora of non-diabetic individuals with that of diabetic patients. Methodology: A prospective study for comparison of conjunctival flora of 50 non-diabetic individuals with that of 50 diabetic individual patients without any pre-existing conjunctival pathology attending the Ophthalmology Out Patient Department in Vinayaka Mission's Kirupanada Variyar Medical College and Hospital, Salem, Tamil Nadu, which is 560 bedded hospital having all inpatients and outpatient services. Conjunctival swab was collected from each patient and inoculation of conjunctival swab for microscopy and culture and sensitivity was done. Identification of Bacteria were made using Standard Bacteriological methods. Result: We found a significant difference in bacterial isolation rate between the diabetic and non-diabetic groups. Conclusion: Organisms such as coagulase negative staphylococcus, gram negative bacteria such as E. coli, klebsiella and bacteroids were found to be more common among the diabetic patients than that of non-diabetic patients.

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Endogenous Endophthalmitis in the Korean Population

Cited by 90 publications

References 29 publications

Conjunctival Flora in Diabetic and Nondiabetic Individuals

Conjunctival Flora in Diabetic and Nondiabetic Individuals

A Case of a Large Sub-retinal Abscess Secondary to Klebsiella pneumoniae Endophthalmitis in a Pyelonephritis Patient

A study to compare the conjunctival flora of non-diabetic individuals with that of diabetic patients

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