Endogenous endophthalmitis due to Listeria monocytogenes

Melamed, J.; Kwitko, Sérgio; Barcaro, Simone; Verri, José M.; Petrillo, V.F.

doi:10.3109/09273949409057801

Cited by 6 publications

(7 citation statements)

References 14 publications

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“…The median age of the patients was 62 (interquartile range (IQR) =18) years, with the youngest being 24 and the oldest at 88 years (Table 1 , 2 ). The present case, as well as nine of the twenty-six published cases of L. monocytogenes endophthalmitis, occurred in immunocompromised patients (37 %) [ 11 , 14 , 17 , 19 , 22 , 25 , 27 , 29 , 34 ]. Five cases (19 %) occurred in patients with chronic diseases such as neurodermitis, sacroiliitis, diabetes mellitus (present case), arterial hypertension, hypothyroidism, or previous history of cancer or surgery (coronary artery bypass graft) [ 16 , 21 , 24 , 26 , 30 ] (Table 2 ) .…”

Section: Review On Symptoms Clinic Treatment and Outcome Of Publishmentioning

confidence: 67%

“…The cause of bacterial endophthalmitis was isolated by recovering Listeria monocytogenes from the anterior chamber (18/21; 86 %), vitreous fluid (7/9; 78 %), or in three cases from blood cultures (3/13; 23 %) (Table 2 ) [ 18 , 22 , 30 ].…”

Section: Review On Symptoms Clinic Treatment and Outcome Of Publishmentioning

confidence: 99%

“…In single cases, the infection led to enucleation, blindness, or strong visual loss [ 19 , 30 , 31 , 33 ]. In eight cases (30 %), a cataract developed, which led to decreased VA with subsequent cataract surgery [ 16 , 18 , 22 , 24 , 25 , 27 – 29 ]. Further ocular surgical operations were needed in five other cases (19 %); two patients needed a keratoplasty, and two other patients needed a trebeculectomy (7 % each) to manage the secondary glaucoma [ 13 , 21 , 22 ].…”

Section: Review On Symptoms Clinic Treatment and Outcome Of Publishmentioning

confidence: 99%

“…In eight cases (30 %), a cataract developed, which led to decreased VA with subsequent cataract surgery [ 16 , 18 , 22 , 24 , 25 , 27 – 29 ]. Further ocular surgical operations were needed in five other cases (19 %); two patients needed a keratoplasty, and two other patients needed a trebeculectomy (7 % each) to manage the secondary glaucoma [ 13 , 21 , 22 ]. One patient required an additional vitrectomy with membrane peeling due to a macula hole and an irisprintlens because of permanent pupillary dilation [ 28 ].…”

Section: Review On Symptoms Clinic Treatment and Outcome Of Publishmentioning

confidence: 99%

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Listeria monocytogenes endophthalmitis – case report and review of risk factors and treatment outcomes

et al. 2016

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BackgroundThe majority of cases of endophthalmitis are caused by exogenous pathogens; only 5–10 % are of endogenous origin. One cause of these rare cases of endogenous endophthalmitis is Listeria monocytogenes. Twenty-six cases of endophthalmitis due to this pathogen have been published over the last twenty years. The aim of this review is to summarize the main risk factors and common clinical findings of endogenous endophthalmitis due to Listeria monocytogenes.Case presentationWe report on a 62-year-old female presenting with a sterile hypopyon iritis with secondary glaucoma and an underlying rheumatoid disease. In microbiological analysis we identified Listeria monocytogenes. Further we searched through all published cases for typical signs, risk factors, details of medical and surgical treatment and outcome of endogenous endophthalmitis due to this rare pathogen.Ocular symptoms in almost all of these published cases included pain, redness of the eye, and decreased vision. Main clinical features included elevated intraocular pressure and fibrinous anterior chamber reaction, as well as a dark hypopyon. While the infection is typically spread endogenously, neither an exogenous nor endogenous source of infection could be identified in most cases. Immunocompromised patients are at higher risk of being infected than immunocompetent patients. The clinical course of endophthalmitis caused by Listeria monocytogenes had different visual outcomes. In some cases, the infection led to enucleation, blindness, or strong visual loss, whereas most patients showed a tendency of visual improvement during therapy.ConclusionEarly diagnosis and treatment initiation are crucial factors in the outcome of endogenous endophthalmitis caused by Listeria monocytogenes. This possible differential diagnosis should be kept in mind while treating patients with presumable sterile hypopyon and anterior uveitis having a high intraocular pressure. A bacterial source should be considered with a prompt initiation of systemic antibiotic treatment, mainly in immunocompromised patients, who develop endogenous anterior uveitis. An appropriate microbiological sampling is essential to detect atypical microorganisms and to choose an effective antibiotic treatment.

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Section: Review On Symptoms Clinic Treatment and Outcome Of Publishmentioning

confidence: 67%

Section: Review On Symptoms Clinic Treatment and Outcome Of Publishmentioning

confidence: 99%

Section: Review On Symptoms Clinic Treatment and Outcome Of Publishmentioning

confidence: 99%

Section: Review On Symptoms Clinic Treatment and Outcome Of Publishmentioning

confidence: 99%

See 2 more Smart Citations

Listeria monocytogenes endophthalmitis – case report and review of risk factors and treatment outcomes

et al. 2016

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“…In all cases the cause of bacterial endophthalmitis was determined by recovering the organism from cultures of intraocular fluids. Six of the 17 published cases of L. monocytogenes endophthalmitis occurred in immunocompromised patients (2,5,7,20,22,25), 6 occurred in elderly patients with good physical health (1,4,14,15,17,19), and the remaining 5 cases affected young healthy individuals (6,8,12,13,29). Our patient had several potentially predisposing factors, including laryngeal carcinoma and immunosuppressive therapy.…”

Section: Case Reportmentioning

confidence: 99%

Endophthalmitis Caused by Listeria monocytogenes

Betriú¹,

Fuentemilla

Méndez

et al. 2001

J Clin Microbiol

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Listeria monocytogenes was isolated from the aqueous chamber of an immunodepressed patient with acute hypertensive uveitis, who developed a dark hypopyon and pigment dispersion. No extraocular septic focus was found. Treatment was successful with intravitreal vancomycin, anterior chamber irrigation with vancomycin, orally administered ciprofloxacin, and topical fortified vancomycin. CASE REPORTA 62-year-old man presented to the emergency department with pain, redness, and decreased vision in the left eye. The patient had a history of laryngeal carcinoma, for which he had undergone laryngectomy and had been treated with radiation therapy and steroids. Examination of the eye on admission revealed acute hypertensive uveitis, and treatment with corticosteroids was begun but did not provide significant improvement. The patient developed a dark hypopyon with pigment dispersion and uveal ectropion. A differential diagnosis was made between endogenous endophthalmitis and a neoplastic process of the ciliary body (either primary ciliary body melanoma or metastatic melanoma from larynx carcinoma). Results from laboratory studies were unremarkable, except for the leukocyte count (14,030/mm 3 with 77% polymorphonuclear neutrophils). The chest X ray was normal. Blood cultures were negative. An ultrasound scan of the eye showed dispersion of echoes, and no evidence of retinal detachment was noted. B-scan ultrasonography revealed inflammatory deposition and pigmentary epithelium detachment. No proliferation was detected in the stromal iris.Anterior chamber paracentesis was performed and submitted for culture and histopathology. Cytological examination showed polymorphonuclear leukocytes and no evidence of neoplastic cells. Because the patient reported a history of penicillin allergy, combined treatment with oral administration of ciprofloxacin (750 mg twice a day), anterior chamber irrigation with vancomycin, and intravitreal vancomycin (1 mg) was started. Topical fortified vancomycin (1 g) and corticotherapy were also applied. The patient's condition improved with treatment. Within 7 days, the hypopyon disappeared and the intraocular pressure decreased. However, visual acuity was limited to appreciation of hand motion, because of a severe corneal edema and a cataract which developed in the patient's left eye.A small amount of fluid obtained by aspiration from the anterior chamber was directly plated onto blood agar and chocolate agar and distributed into aerobic and anaerobic blood culture bottles processed by the BACTEC 9050 system (Becton Dickinson Microbiology Systems, Cockeysville, Md.). Gram staining was performed and no organisms were observed. After a 24-h incubation of plates at 35°C in a 5% CO 2 -enriched atmosphere, catalase-positive, gram-positive coccobacilli grew, producing beta-hemolysis on blood agar. The isolate was identified as Listeria monocytogenes by both the Wider system (Francisco Soria Melguizo, S.A., Madrid, Spain) and the API Listeria system (bioMérieux, Marcy l'Etoile, France). Pure culture of L. mon...

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