Endogenous Electric‐Field‐Coupled Electrospun Short Fiber via Collecting Wound Exudation (Adv. Mater. 9/2022)

Abstract

Tissue Repair In article number 2108325, Wenguo Cui and co‐workers report the fabrication of a 3D bionic short fiber scaffold with excellent reversible hydroscopicity and biostable conductivity. This scaffold helps to achieve precise tissue remodeling by collecting a large amount of secretions in the early stages of wound healing and transmitting bioelectrical signals to proactively match the cascade reaction of tissue repair.

Multisite Captured Copper Ions via Phosphorus Dendrons Functionalized Electrospun Short Nanofibrous Sponges for Bone Regeneration

“…However, the porosity of 3D‐NS@PD@Cu(II) can still meet the requirements of cell growth and nutrient exchange. [ 24 ] As for the expansion, the 3D‐NS@PD@Cu(II) was slightly lower than the 3D‐NS@PD, which also due to the presence of captured Cu 2+ (Figure 1F). As shown in Figure 2G, the 3D‐NS@PD and 3D‐NS@PD@Cu(II) showed reversible water absorption.…”

“…Glutaraldehyde, a widely utilized chemical crosslinking agent, can form chemical bonds to achieve the effect of cross‐linking. [ 24 ] Therefore, glutaraldehyde was utilized in this study to maintain the structure as well as enhance the mechanical properties of the 3D‐NS. Afterwards, the cross‐linked 3D‐NS was immersed into 5% glutamate/hydrochloric acid for ≈48 h to remove the residual reagent of glutaraldehyde.…”

“…As shown in Figure B, the cross‐linked 3D‐NS had a stable morphological structure, which could stably retain its complete morphological structure in PBS (Figure S1 and Video S1, Supporting Information). Compared with traditional electrospun fibers, 3D‐NS has many unique advantages: [ 24,25 ] 1) 3D‐NS has higher porosity than traditional electrospinning fibers, which is conducive to cells adhesion and ingrowth; 2) the high porosity structure of 3D‐NS contributes to material exchange and nutrient supply; 3) 3D‐NS can better simulate the extracellular matrix (ECM) and provide a more suitable microenvironment for cells growth, proliferation, and differentiation. In view of the above advantages of 3D‐NS, it is used as the main material for functional modification.…”

A Diagnostic and Therapeutic Hydrogel to Promote Vascularization via Blood Sugar Reduction for Wound Healing

“…The “diagnostic and therapeutic” UGV hydrogel, as an implantable material, is required to have good biocompatibility. [ 24 ] Furthermore, the healing of diabetic skin defects is greatly influenced and reflected by the migration and functional alterations of fibroblasts and endothelial cells. [ 6,25 ] Therefore, the biocompatibility of the UGV hydrogel was examined through live–dead staining of fibroblasts and endothelial cells, skeletal staining, CCK8, and lactate dehydrogenase (LDH).…”

Self‐Pumping Janus Hydrogel with Aligned Channels for Accelerating Diabetic Wound Healing

“…[ 2–7 ] The timely and effective drainage of exudate is of great significance to alleviating patients’ suffering and reducing the healthcare burden. [ 4 ] To date, several hydrophilic and nontoxic materials including hydrogels (e.g., gelatin, [ 8,9 ] chitosan [ 8,10–12 ] ), aerogels (e.g., polyethylene glycol [ 13 ] ), electrospun fibers, [ 14 ] sponges, [ 15 ] and silk proteins [ 16–19 ] have been used as promising wound dressings to promote wound healing. However, their inherent hydrophilicity also inevitably leads to some exudate remaining at the interface between the wound and dressing, which is detrimental to wound healing and results in secondary damage upon dressing changes.…”