Endogenous Ecotropic Murine Leukemia Viral (MuLV) Envelope Protein as a New Autoantigen Reactive with Non-obese Diabetic Mice Sera

Choi, Sung‐E; Kim, Kyung-Soo; Kim, Kihwan; Choi, U-Yeol; Kim, Hyeon-Man; Yoon, Ji‐Won; Kang, Yup

doi:10.1006/jaut.2000.0434

Cited by 6 publications

(2 citation statements)

References 49 publications

(41 reference statements)

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“…Со времени первых сообщений об аутоантителах к островковым клеткам были идентифицированы многие аутоантигены у людей, Not obese diabetes (NOD) мышей и Biobreding (ВВ) крыс, способные стать мишенью для аутоиммунной агрессии. К таким аутоантигенам относятся: содержащий гликолипид аутоантиген островковых клеток со свойствами сиаловой кислоты [3], инсулин [4], рецептор инсулина [5], белок с молекулярной массой 52 кДа [6,7], белок с молекулярной массой 69 кД [8,9], декарбок-силаза глутаминовой кислоты (GAD) [10], тирозинфосфатаза-2 (IA-2) [11,12], белок теплового шока с молекулярной массой 52 кДА (HSP65) [13,14], карбоксипептидаза Н (СНР) [15], транспортер глюкозы [16], аутоантиген с молекулярной массой 38 кДа [17,18], ретровирусный антиген [19] и определяющий пол участок Y-ассоциированного белка [20].…”

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Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8)

et al. 2011

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The progressive loss of beta cells in Type 1 Diabetes (T1D) is a result of chronic autoimmune attack targeted at diverse molecules expressing in thepancreatic beta cells. The appearance of cellular and humoral autoimmunity precedes the clinical manifestation of T1D. There are several autoantigenswhich are supposed to be involved in pathogenesis of TD1. Zinc transporter 8 (ZnT8; Slc30A8) was identified as a novel T1D autoimmunitytarget.

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Section: сахарный диабетunclassified

Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8)

et al. 2011

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“…Since the first reports of anti-islet cell autoantibodies in 1974 [10], many autoantigens in humans, NOD mice and BB rats have been identified, including an islet cell autoantigen with properties of sialic acid containing glycolipid [11], insulin [12], the insulin receptor [13], a 52-kDa protein [14,15], a 69-kDa protein [16,17], glutamic acid decarboxylase (GAD) [18], tyrosine phosphatase-2 (IA-2) [19,20], heat shock protein 65 (HSP65) [21,22], carboxypeptidase H (CPH) [23], the glucose transporter [24], a 38-kDa autoantigen [25,26], a retroviral antigen [27] and sex-determining region Y-related protein [28]. Among these autoantigens, GAD has been extensively studied with regard to its pathogenic role in the development of T1DM.…”

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confidence: 99%

Role of glutamic acid decarboxylase in the pathogenesis of type 1 diabetes

Lee¹,

Khil²,

Yoon³

2002

CMLS, Cell. Mol. Life Sci.

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Glutamic acid decarboxylase (GAD) is considered to be one of the strongest candidate autoantigens involved in triggering beta-cell-specific autoimmunity. The majority of recent onset type 1 diabetes patients and pre-diabetic subjects have anti-GAD antibodies in their sera, as do nonobese diabetic (NOD) mice, one of the best animal models for human type I diabetes. Immunization of young NOD mice with GAD results in the prevention or delay of the disease as a result of tolerizing autoreactive T cells. Autoimmune diabetes can also be prevented by the suppression of GAD expression in antisense GAD transgenic mice backcrossed with NOD mice for seven generations. These results support the hypothesis that GAD plays an important role in the development of T-cell-mediated autoimmune diabetes. However, there is some controversy regarding the role of GAD in the pathogenesis of diabetes. Whether GAD truly plays a key role in the initiation of this disease remains to be determined. The examination of the development of insulitis and diabetes in beta-cell-specific GAD knockout NOD mice will answer this remaining question.

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An autoimmune biliary disease mouse model for primary biliary cirrhosis: Something for everyone

Mason

2006

Hepatology

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Primary biliary cirrhosis (PBC) is an autoimmune disease with a strong genetic component characterized by biliary ductular inflammation with eventual liver cirrhosis. The serologic hallmark of PBC is antimitochondrial antibodies that react with the pyruvate dehydrogenase complex, targeting the inner lipoyl domain of the E2 subunit (anti‐PDC‐E2). Herein we demonstrate that NOD.c3c4 mice congenically derived from the non‐obese diabetic strain develop an autoimmune biliary disease (ABD) that models human PBC. NOD.c3c4 (at 9‐10 wk, before significant biliary pathology) develop antibodies to PDC‐E2 that are specific for the inner lipoyl domain. Affected areas of biliary epithelium are infiltrated with CD3+, CD4+, and CD8+ T cells, and treatment of NOD.c3c4 mice with monoclonal antibody to CD3 protects from ABD. Furthermore, NOD.c3c4‐scid mice develop disease after adoptive transfer of splenocytes or CD4+ T cells, demonstrating a central role for T cells in pathogenesis. Histological analysis reveals destructive cholangitis, granuloma formation, and eosinophilic infiltration as seen in PBC, although, unlike PBC, the extrahepatic biliary ducts are also affected. Using a congenic mapping approach, we define the first ABD (Abd) locus, Abd1. These results identify the NOD.c3c4 mouse as the first spontaneous mouse model of PBC.

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Endogenous Ecotropic Murine Leukemia Viral (MuLV) Envelope Protein as a New Autoantigen Reactive with Non-obese Diabetic Mice Sera

Cited by 6 publications

References 49 publications

Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8)

Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8)

Role of glutamic acid decarboxylase in the pathogenesis of type 1 diabetes

An autoimmune biliary disease mouse model for primary biliary cirrhosis: Something for everyone

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