Endogenous dopamine transmission is crucial for motor skill recovery after stroke

Vitrac, Clément; Nallet-Khosrofian, Lauriane; Iijima, Maiko; Rioult-Pedotti, Mengia-Seraina; Luft, Andreas R.

doi:10.1016/j.ibneur.2022.05.008

Cited by 8 publications

(7 citation statements)

References 57 publications

(89 reference statements)

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“…Thus, dopaminergic signaling within the PIC may facilitate network plasticity, which forms the basis for motor recovery and successful rehabilitation. In line with this hypothesis, blocking D1‐ and D2‐receptors in the ischemic region impaired the recovery of motor skills on Days 7–12 after PTS (Vitrac et al, 2022). In turn, preventing post‐stroke degeneration of dopaminergic midbrain neurons using the neuroprotective peptide Substance P facilitated motor rehabilitation with a forelimb grasping task contralateral to the lesioned hemisphere (Frase et al, 2022).…”

Section: Discussionmentioning

confidence: 84%

“…In turn, levodopa treatment after stroke increased GDNF levels within the lesioned hemisphere. In line with a beneficial effect of dopamine-dependent GDNF expression on recovery, continuous infusion of D1 and D2 dopamine receptor antagonists into the PIC interfered with motor rehabilitation in a rat model of motor-cortical photothrombotic stroke (Vitrac et al, 2022).…”

Section: Introductionmentioning

confidence: 77%

“…In turn, levodopa treatment after stroke increased GDNF levels within the lesioned hemisphere. In line with a beneficial effect of dopamine‐dependent GDNF expression on recovery, continuous infusion of D1 and D2 dopamine receptor antagonists into the PIC interfered with motor rehabilitation in a rat model of motor‐cortical photothrombotic stroke (Vitrac et al, 2022). Levodopa treatment, on the other hand, supported recovery of sensorimotor function after transient occlusion of the middle cerebral artery (MCAO) in rats (Ruscher et al, 2012).…”

Section: Introductionmentioning

confidence: 95%

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Dense dopaminergic innervation of the peri‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats

Frase,

Steddin,

Paschen

et al. 2023

Journal of Neurochemistry

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After ischemic stroke, the cortex directly adjacent to the ischemic core (i.e., the peri‐infarct cortex, PIC) undergoes plastic changes that facilitate motor recovery. Dopaminergic signaling is thought to support this process. However, ischemic stroke also leads to the remote degeneration of dopaminergic midbrain neurons, possibly interfering with this beneficial effect. In this study, we assessed the reorganization of dopaminergic innervation of the PIC in a rat model of focal cortical stroke. Adult Sprague–Dawley rats either received a photothrombotic stroke (PTS) in the primary motor cortex (M1) or a sham operation. 30 days after PTS or sham procedure, the retrograde tracer Micro Ruby (MR) was injected into the PIC of stroke animals or into homotopic cortical areas of matched sham rats. Thus, dopaminergic midbrain neurons projecting into the PIC were identified based on MR signal and immunoreactivity against tyrosine hydroxylase (TH), a marker for dopaminergic neurons. The density of dopaminergic innervation within the PIC was assessed by quantification of dopaminergic boutons indicated by TH‐immunoreactivity. Regarding postsynaptic processes, expression of dopamine receptors (D1‐ and D2) and a marker of the functional signal cascade (DARPP‐32) were visualized histologically. Despite a 25% ipsilesional loss of dopaminergic midbrain neurons after PTS, the number and spatial distribution of dopaminergic neurons projecting to the PIC was not different compared to sham controls. Moreover, the density of dopaminergic innervation in the PIC was significantly higher than in homotopic cortical areas of the sham group. Within the PIC, D1‐receptors were expressed in neurons, whereas D2‐receptors were confined to astrocytes. The intensity of D1‐ and DARPP‐32 expression appeared to be higher in the PIC compared to the contralesional homotopic cortex. Our data suggest a sprouting of dopaminergic fibers into the PIC and point to a role for dopaminergic signaling in reparative mechanisms post‐stroke, potentially related to recovery.image

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 95%

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Dense dopaminergic innervation of the peri‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats

Frase,

Steddin,

Paschen

et al. 2023

Journal of Neurochemistry

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“…60 Moreover, there are animal studies showing that dopamine transmission is important to drive motor rehabilitation after stroke through motivational aspects and suggesting that augmented motivation and reward feedback could be an interesting strategy to increase the effectiveness or rehabilitation. 12…”

Section: Neurophysiological Basis Of Neuroeconomics Approach To Motor...mentioning

confidence: 99%

“…DM and motor recovery are linked to the same brain areas [9][10][11] and neurochemical systems. 12 Moreover, there are first promising findings suggesting the relatedness of DM to motor impairment. 13 Thus, we argue that it is timely to further develop this line of research by investigating the role of the MDM parameters in motor impairment with an idea to adapt existing NE approaches to neurorehabilitation, aiming primarily to increase patient motivation, possibly leading to an increased number of movements performed, but also at making every movement more engaging.…”

Section: Introductionmentioning

confidence: 99%

Motor Decision-Making as a Common Denominator in Motor Pathology and a Possible Rehabilitation Target

Germanova

Panidi

Ivanov

et al. 2023

Neurorehabil Neural Repair

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Despite the substantial progress in motor rehabilitation, patient involvement and motivation remain major challenges. They are typically addressed with communicational and environmental strategies, as well as with improved goal-setting procedures. Here we suggest a new research direction and framework involving Neuroeconomics principles to investigate the role of Motor Decision-Making (MDM) parameters in motivational component and motor performance in rehabilitation. We argue that investigating NE principles could bring new approaches aimed at increasing active patient engagement in the rehabilitation process by introducing more movement choice, and adapting existing goal-setting procedures. We discuss possible MDM implementation strategies and illustrate possible research directions using examples of stroke and psychiatric disorders.

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Phosphodiesterase 10A deactivation induces long-term neurological recovery, Peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice

Beker

Pence

Yagmur

et al. 2022

Experimental Neurology

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Endogenous dopamine transmission is crucial for motor skill recovery after stroke

Cited by 8 publications

References 57 publications

Dense dopaminergic innervation of the peri‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats

Dense dopaminergic innervation of the peri‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats

Motor Decision-Making as a Common Denominator in Motor Pathology and a Possible Rehabilitation Target

Phosphodiesterase 10A deactivation induces long-term neurological recovery, Peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice

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