Endogenous digoxin-like immunoreactivity in congestive heart failure.

Shilo, Lotan; Adawi, Amin; Solomon, Gili; Shenkman, Louis

doi:10.1136/bmj.295.6595.415-a

Cited by 39 publications

(9 citation statements)

References 4 publications

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“…Di goxin-like immunoreactive substances are reportedly in creased in plasma or urine from patients with renal fail ure, liver failure or heart failure, from newborn infants, from pregnant women and from normal subjects during exercises (3,8,9]. However, the effects of salt loading on digoxin-like immunoreactivity in plasma or urine are not necessarily consistent [10][11][12], Our results may explain these discrepancies.…”

contrasting

confidence: 49%

Does Digoxin-Like Immunoreactivity Really Represent the Natriuretic Hormone?

Goto

Yamada²,

Ishii³

et al. 1990

Nephron

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contrasting

confidence: 49%

Does Digoxin-Like Immunoreactivity Really Represent the Natriuretic Hormone?

Goto

Yamada²,

Ishii³

et al. 1990

Nephron

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“…We have previously shown that DLIF exists in serum in three forms: protein-bound, glucuronidated, and free, with respective molecular weights of 5000, 400, and 230 daltons (13). Boiling of serum, or treatment with trichloroacetic acid, releases the protein-bound form, and raises the detectable levels of DLIF (11). If untreated serum is assayed, free levels of DLIF are measured in the digoxin radioimmunoassay.…”

Section: Methodsmentioning

confidence: 99%

“…Like digitalis, DLIF inhibits the activity of (Na-K)ATPase (18,19). In view of the role of the (Na-K)ATPase pump in bile flow and clearance (20, 21), we postulated that a relationship exists between hyperbilirubinemia in the newborn period and serum levels of DLIE (11).…”

mentioning

confidence: 99%

Endogenous Digoxin-Like Factor in Neonates: Effect of Age and Relation to Serum Bilirubin Levels

Wolach¹,

Carmi²,

Shilo³

et al. 1989

Acta Paediatrica

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Endogenous digoxin-like immunoreactive factor(s) (DLIF) have been found in serum and urine of newborn infants, including those born prematurely. We assessed the effect of age on serum levels of DLIF in 73 samples obtained from 66 healthy full term newborn infants at birth and during the first two months of life. DLIF concentrations were highest at birth and fell progressively with age. In cord blood, DLIF levels were 0.73 +/- 0.35 ng/ml (mean +/- SD). DLIF concentrations were 0.45 +/- 0.11 ng/ml on day 1, 0.26 +/- 0.08 ng/ml on day 3, 0.19 +/- 0.07 ng/ml on day 5, 0.17 +/- 0.09 ng/ml on day 11, 0.11 +/- 0.02 ng/ml on days 15-30, and not detectable after 45 days of life. We also studied the relation between serum levels of DLIF and bilirubin in 23 jaundiced newborns between 3-5 days of life. We found a highly significant positive correlation between serum bilirubin concentrations and DLIF. These findings support the assumption that DLIF plays a role in impeding bilirubin excretion in the neonatal period, perhaps by inhibiting the activity of (Na-K)ATPase.

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“…An endogenous substance cross-reacting with anti-digoxin antibodies was first reported in animals by Gruber et al (1). Subsequently, it was found in a variety of physiologic and pathologic conditions including pregnancy, premature and full-term infants, hepatic, renal, and cardiac diseases, essential hypertension (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Several observations have suggested that this material may be an endogenous digoxin-like factor, which, like cardiac glycosides, inhibits Na þ K þ -ATPase (14).…”

mentioning

confidence: 99%

Serum digoxin-like immunoreactive factor in children and its relation to sodium metabolism

Garbagnati¹

1998

SPAE

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Serum digoxin-like immunoreactive factor (DLIF), an endogenous substance that cross-reacts with antidigoxin antibodies, was assessed (fluorescence polarization immunoassay) in children (n = 134) aged 5-16 y, who had never been treated with cardiac glycosides. DLIF was found in 50% of serum samples at a mean concentration of 0.16 +/- 0.06 ng/ml (range 0.03-0.35 ng/ml). Although the study population as a whole was apparently homogeneous with regard to serum sodium content, and none had clinical signs of sodium imbalance, children with DLIF showed significantly lower natraemia (p = 0.0002), higher urinary concentration (p = 0.001) and fractional excretion (p = 0.001) of sodium, and increased systolic blood pressure (p = 0.009) compared with children without DLIF. Inverse correlations were found between DLIF concentration and serum sodium (p < 0.01), urine sodium content (p < 0.001), 24-h sodium excretion (p < 0.001), systolic (p < 0.001) and diastolic (p < 0.01) blood pressure. These findings suggest that sodium handling is different in children with and without DLIF, since this material seems to be released preferably in subjects who show a trend towards negative sodium balance. Such an association suggests that DLIF may be a physiologically relevant material involved in sodium homeostasis.

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Endogenous digoxin-like immunoreactivity in congestive heart failure.

Cited by 39 publications

References 4 publications

Does Digoxin-Like Immunoreactivity Really Represent the Natriuretic Hormone?

Does Digoxin-Like Immunoreactivity Really Represent the Natriuretic Hormone?

Endogenous Digoxin-Like Factor in Neonates: Effect of Age and Relation to Serum Bilirubin Levels

Serum digoxin-like immunoreactive factor in children and its relation to sodium metabolism

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