Endogenous Cholinergic Input to the Pontine REM Sleep Generator Is Not Required for REM Sleep to Occur

Grace, Kevin P.; Vanstone, Lindsay E.; Horner, Richard L.

doi:10.1523/jneurosci.0274-14.2014

Cited by 40 publications

(46 citation statements)

References 49 publications

(24 reference statements)

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“…In vivo and in vitro recordings show that carbachol excites REM sleep-active and spinally-projecting SLD neurons (Sakai et al, 2001; Weng et al, 2014). However, this cholinergic input may not be necessary as blocking cholinergic signaling in the SLD does not alter the amount of REM sleep or the duration of REM sleep bouts (Grace et al, 2014). …”

Section: Regulation Of Rem Sleepmentioning

confidence: 99%

Neural Circuitry of Wakefulness and Sleep

Scammell

Arrigoni

Lipton

2017

Neuron

689

616

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SUMMARY Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review current perspectives on the neural systems that regulate sleep/wake states in mammals and the circadian mechanisms that control their timing. We also outline key models for the regulation of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition between specific pathways gives rise to these distinct states, and how dysfunction in these circuits can give rise to sleep disorders.

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Section: Regulation Of Rem Sleepmentioning

confidence: 99%

Neural Circuitry of Wakefulness and Sleep

Scammell

Arrigoni

Lipton

2017

Neuron

689

616

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“…Additionally, PPN cholinergic cells have been indicated to play a role in mediating REM sleep, although their activation may not be a necessary prerequisite for REM sleep to occur (Grace et al, 2014;Van Dort et al, 2015). The intricate mechanism and the putative role of the PPN in mediating or modulating REM sleep is beyond the scope of this article and we refer to other elaborate reviews that have been published before (Garcia-Rill et al, 2015;Rye, 1997).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Pedunculopontine nucleus: An integrative view with implications on Deep Brain Stimulation

Nowacki

Galati

Ai-Schlaeppi

et al. 2019

Neurobiology of Disease

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The pedunculopontine nucleus (PPN) is a reticular nucleus located in the mesencephalic and upper pontine tegmentum. Initially, characterized by its predominant cholinergic projection neurons, it was associated with the "mesencephalic locomotor region" and "reticular activating system". Furthermore, based on histopathological studies, the PPN was hypothesized to play a role in the manifestation of symptoms in movement disorders such as Parkinson's disease (PD). Since axial symptoms represent unmet needs of PD treatments, a series of pioneering experiments in Parkinsonian monkeys promoted the idea of a potential new target for deep brain stimulation (DBS) and much clinical interest was generated in the following years leading to a number of trials analysing the role of PPN for gait disorders. This review summarizes the historical background and more recent findings about the anatomy and function of the PPN and its implications in the basal ganglia network of the normal as well as diseased brain. Classical views on PPN function shall be challenged by more recent findings. Additionally, the current role and future perspectives of PPN DBS in PD patients shall be outlined.

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“…Also, cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei (PPT/LDT) are active during REM sleep and project to the SLD and optogenetic activation of these neurons during non-REM sleep promotes REM sleep [114,115]. It should, however, be noted that more recent studies have cast doubt on the claim of sufficiency and necessity of the cholinergic PPT/LDT or cholinergic inputs to the SLD in REM sleep control [116,117]. Finally, a role for the supramammillary hypothalamus, in particular resident glutamate-releasing/Nos1-expressing neurons, in the regulation of REM sleep and REM hippocampal theta has been recently reported [118,119].…”

Section: Brain Circuitry Controlling Rem Sleepmentioning

confidence: 99%

Neuroscience: A Distributed Neural Network Controls REM Sleep

Peever

Fuller

2016

Current Biology

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Considerable advances in our understanding of the mechanisms and functions of rapid-eye-movement (REM) sleep have occurred over the past decade. Much of this progress can be attributed to the development of new neuroscience tools that have enabled high-precision interrogation of brain circuitry linked with REM sleep control, in turn revealing how REM sleep mechanisms themselves impact processes such as sensorimotor function. This review is intended to update the general scientific community about the recent mechanistic, functional and conceptual developments in our current understanding of REM sleep biology and pathobiology. Specifically, this review outlines the historical origins of the discovery of REM sleep, the diversity of REM sleep expression across and within species, the potential functions of REM sleep (e.g., memory consolidation), the neural circuits that control REM sleep, and how dysfunction of REM sleep mechanisms underlie debilitating sleep disorders such as REM sleep behaviour disorder and narcolepsy.

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Endogenous Cholinergic Input to the Pontine REM Sleep Generator Is Not Required for REM Sleep to Occur

Cited by 40 publications

References 49 publications

Neural Circuitry of Wakefulness and Sleep

Neural Circuitry of Wakefulness and Sleep

Pedunculopontine nucleus: An integrative view with implications on Deep Brain Stimulation

Neuroscience: A Distributed Neural Network Controls REM Sleep

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