Abstract:IN the course of studies of coagulation defects found in experimentally produced shock in dogs it was noted that many dogs that died showed abnormal and clinically visible bleeding which occurred during the late phases of shock and often as a terminal event. A study was undertaken to determine if these events were associated with changes in the clotting mechanism and particularly if anticoagulant substances were produced by the shock state. This communication re-Forts the results of this inquiry. Materials and… Show more
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