Endogenous anti-tumor antibody responses in nude mice

Stigbrand, Torgny; Ullén, Anders; Sandström, Per; Rathsman, Sandra; Norrlund, Rauni Rossi; Ärlestig, Lisbeth; Åhlström, Katrine Riklund; Hietala, Sven‐Ola

doi:10.1002/(sici)1097-0142(19971215)80:12+<2404::aid-cncr11>3.0.co;2-g

Cited by 2 publications

(1 citation statement)

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“…The HUCPVC cell‐based delivery platform successfully improved the prophylactic efficacy of an existing medical countermeasure, the humanized anti‐VEEV antibody, and dramatically reduced both morbidity and mortality in recipients. Although we used athymic nude mice, they can still mount an adaptive antibody response against human antigens [52] and thereby truncate the half‐life of the humanized antibody. We have shown in the present study that the serum half‐life of anti‐VEEV in nude mice is only slightly longer than previously observed in wild‐type mice [45] (3.7 vs. 2.25 days, respectively).…”

Section: Discussionmentioning

confidence: 99%

Engineered Mesenchymal Cells Improve Passive Immune Protection Against Lethal Venezuelan Equine Encephalitis Virus Exposure

Braid

Davies

et al. 2016

Stem Cells Translational Medicine

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Direct injection of monoclonal antibodies (mAbs) is an important strategy to immediately protect the recipient from a pathogen. This strategy is critical during natural outbreaks or after the intentional release of bio-weapons. Vaccines require weeks to become effective, which is not practical for first responders immediately deployed to an infected region. However, mAb recipients often require booster shots to maintain protection, which is expensive and impractical once the first responders have been deployed. The present study has shown, for the first time, that mesenchymal stromal cells are effective gene delivery vehicles that can significantly improve mAb-mediated immune protection in a single, intramuscular dose of engineered cells. Such a cell-based delivery system can provide extended life-saving protection in the event of exposure to biological threats using a more practical, single-dose regimen.

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Section: Discussionmentioning

confidence: 99%