Endogenous and postheparin monoglyceride hydrolase in plasma of patients with acute virus hepatitis

Abstract

Endogenous and postheparin monoglyceride hydrolase (MGH) was studied in 9 patients with acute virus hepatitis and in 25 normal subjects with the use of a new spectrophotometric method. During the 4 weeks of observation the patients had significantly higher endogenous and reduced postheparin MGH levels if compared with the controls (p smaller than 0.001). In the initial phase of hepatitis the alterations were more pronounced and the serum glyceride concentration was raised. The results show that MGM activities in plasma may be greatly influenced by the liver.

A Spectrophotometric Method for the Determination of Monoglyceride Hydrolase

“…In order to establish the acourancy of the monoglyceride hydrolase test in 72 samples, measurements were also carried out with another method (4). In this method glycerol monopalmitate is used as substrate.…”

“…After the administration of heparin, the enzyme activity increases (2). Monoglyceride hydrolase has found interest as a key enzyme in the metabolism of plasma triglycerides as well as a diagnostic tool for assessing the function of the liver (1,(3)(4)(5).…”

“…For comparison monoglyceride hydrolase was also determined by another method which has been published elsewhere(4). Under this condition monoglyceride hydrolase activity was 458 χ tg a.…”