Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters
Laura Depta,
Hogan P. Bryce-Rogers,
Nienke J. Dekker
et al.
Abstract:Sterol transport proteins (STPs) play a pivotal role in cholesterol homeostasis and therefore are essential for healthy human physiology. Despite recent advances in dissecting functions of STPs in the human cell, there is still a significant knowledge gap regarding their specific biological functions and a lack of suitable selective probes for their study. Here, we profile fluorescent steroid-based probes across ten STPs, uncovering substantial differences in their selectivity, aiding the retrospective and pro… Show more
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