1996
DOI: 10.1016/s0378-4347(96)00255-1
|View full text |Cite
|
Sign up to set email alerts
|

Endogenous alkaloids in man XXVI. Determination of the dopaminergic neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) in biological samples using gas chromatography with selected ion monitoring

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

1998
1998
2014
2014

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 14 publications
(3 citation statements)
references
References 19 publications
0
3
0
Order By: Relevance
“…Like MPTP, it freely crosses the BBB , and it specifi cally inhibits mitochondrial Complex 1-though TaClo and its metabolites are at least an order of magnitude more potent (Janetzky et al 1995 ;Bringmann et al 1995 ). TaClo is a dopaminergic toxin both in culture and in vivo Bringmann et al 1995Bringmann et al , 1996Riederer et al 2002 ;Heim and Sontag 1997 ;Grote et al 1995 ). Injection of TaClo into the SNpc of rats resulted in a 15 % decrease in neuronal count .…”
Section: Tce and Parkinson's Disease (Pd): Potential Biological Mechamentioning
confidence: 99%
“…Like MPTP, it freely crosses the BBB , and it specifi cally inhibits mitochondrial Complex 1-though TaClo and its metabolites are at least an order of magnitude more potent (Janetzky et al 1995 ;Bringmann et al 1995 ). TaClo is a dopaminergic toxin both in culture and in vivo Bringmann et al 1995Bringmann et al , 1996Riederer et al 2002 ;Heim and Sontag 1997 ;Grote et al 1995 ). Injection of TaClo into the SNpc of rats resulted in a 15 % decrease in neuronal count .…”
Section: Tce and Parkinson's Disease (Pd): Potential Biological Mechamentioning
confidence: 99%
“…After centrifugation (30 min), the clear sample solution was carefully transferred to a new vial. After addition of 50 l of 0.1 M sodium hydroxide, further sample workup was accomplished subsequently on a 100-mg sorbent C 18 cartridge (cleanup, C18 octadecyl encapped, United Chemical Technologies Inc.) according to a procedure, the reliability of which has been outlined in detail previously (18). Prior to solid-phase extraction, the cartridge was conditioned with 2 ml of methanol followed by 3 ml of water.…”
Section: Cleanup Procedures For Blood Samplesmentioning
confidence: 99%
“…We wish to emphasize particularly that every GC run of a purified human blood sample was performed after several injections of pure toluene to really avoid any memory effects on the capillary column used. First, we focused on the investigation of the clot fractions because former studies on blood samples of TaClo-treated rats had revealed this substance to mainly occur in the fraction of lysed erythrocytes (5,6,18), presumably due to the unpolar character of the TaClo molecule. Indeed, the chromatograms (Fig.…”
Section: Fig 2 (A) Trifluoroacetylation Of Taclomentioning
confidence: 99%