Endodontics, Endodontic Retreatment, and Apical Surgery Versus Tooth Extraction and Implant Placement: A Systematic Review

Chércoles-Ruiz, Anna; Sánchez‐Torres, Alba; Gay‐Escoda, Cosme

doi:10.1016/j.joen.2017.01.004

Cited by 71 publications

(57 citation statements)

References 60 publications

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“…Apicectomy is a common procedure in endodontic surgery hat aims to remove periapical lesions (granuloma or cysts) in cases of post‐treatment endodontic disease following conventional root canal treatment (Chercoles‐Ruiz et al . 2017). Most often the procedure is followed by root‐end filling.…”

Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory and immunomodulatory effects of Biodentine on human periapical lesion cells in culture

Eraković

Duka

Bekić³

et al. 2020

Int Endodontic J

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Aim To evaluate the effect of Biodentine eluate on cytotoxicity and production of pro‐ and anti‐inflammatory cytokines and osteodestructive/osteoprotective cytokines in cultures of human periapical lesion cells. Methodology Conditioned Biodentine Medium (CBM) was prepared according to ISO 10993‐12, by incubating Biodentine in RPMI medium (0.2 g mL−1) for 3 days at 37 °C. CBM contained both released microparticles and leachable soluble components. Inflammatory cells were isolated from 22 human periapical lesions after apicectomy or tooth extraction, by collagenase/DNase digestion, and cultured in several dilutions of CBM. The composition of periapical lesion cells was determined by morphological criteria, cytotoxicity was quantified by MTT and flow cytometric apoptosis/necrosis assays, whereas the levels of produced cytokines in cell culture supernatants were measured by flow cytometry and ELISA. Student t‐test and Friedman test with Dunn's post‐test were used for comparison of parametric and nonparametric variables, respectively. Results Undiluted (100%), 75% and 50% CBM were cytotoxic for periapical lesion cells due to induction of both necrosis (100% CBM) and apoptosis (75% and 50% CBM). Noncytotoxic concentrations of CBM (25%) inhibited the production of pro‐inflammatory cytokines: TNF‐α, (P < 0.005); IL‐1β (P < 0.01); IL‐6 (P < 0.005) and chemokines IL‐8: (P < 0.005); MCP‐1 (P < 0.005), stimulated the production of anti‐inflammatory cytokine (IL‐10; P < 0.005), Th2 cytokines: IL‐4, IL‐5 and IL‐33 (all P < 0.01), and IL‐17A (P < 0.01). The concentration of CBM (12.5%) inhibited the production of IL‐6 (P < 0.05), IL‐8 (P < 0.01) and MCP‐1 (P < 0.005) and augmented the production of IL‐10 (P < 0.05). No significant effects on Th1‐related cytokines (IFN‐γ and IL‐12) and IL‐23 were detected with 25% and 12.5% CBM concentrations. Both CBM concentrations inhibited the production of osteolytic receptor activator of nuclear factor kappa‐Β ligand (RANKL), dose dependently (P < 0.005 and P < 0.01, respectively). Higher CBM concentrations decreased RANKL/osteoprotegerin (OPG) ratio (P < 0.05), without significant influence on the levels of osteoprotective OPG. Conclusion Biodentine possesses immunomodulatory properties by suppressing pro‐inflammatory and augmenting anti‐inflammatory cytokines. Together with the reduction of osteodestructive mediators, this novel root‐end filling cement could be beneficial for healing and bone reparation after the surgical treatment of periapical lesions.

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Section: Discussionmentioning

confidence: 99%

Anti‐inflammatory and immunomodulatory effects of Biodentine on human periapical lesion cells in culture

Eraković

Duka

Bekić³

et al. 2020

Int Endodontic J

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“…La relación entre el pronóstico y el tipo de diente no está muy claro todavía, muchos autores coinciden en que los incisivos y los caninos tienen mayor tasa de éxito 23,24 , lo que puede explicarse porque los sectores anteriores son más accesibles y permiten una excelente vista del campo operatorio, favoreciéndose obtener un mejor sellado apical. Barone et al 25 encontraron que lesiones menores o igual a 10 mm tenían una tasa de éxito.…”

Section: Discussionunclassified

Tratamiento de lesión periapical con obturación retrógrada e injerto óseo. Reporte de un caso

Peñafiel¹,

Pallaroso²,

Viteri³

2019

Odontol. sanmarquina

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El objetivo de este estudio es presentar un caso en el que tras el fracaso del tratamiento endodóntico se observó una lesión quística en el periápice. El presente caso trata de una paciente femenina de 39 años de edad, sin antecedentes médicos relevantes quien asistió a la clínica odontológica SERODU, determinando a la palpación la presencia de una tumefacción de consistencia blanda que estaría afectando la integridad del tejido óseo, sin sintomatología. Las pruebas de vitalidad pulpar resultaron negativas. Al examen radiográfico se observó una sombra radiolúcida compatible con lesión periapical crónica que afecta a las piezas dentales 11 y 12. Por lo que se decidió llevar a cabo la cirugía periapical con apicectomía, sellado apical retrógrado y enucleación de la lesión quística, seguido de regeneración ósea guiada. A los tres meses de control, radiográficamente se encontró una zona radiopaca compatible con regeneración ósea con un halo radiolúcido de separación con el hueso basal original, y a los seis meses, se observó la regeneración ósea completa. La técnica de obturación retrógrada e injerto óseo constituye una técnica de tratamiento efectivo para el sellado del conducto a nivel apical y la regeneración de defectos periapicales de gran tamaño.

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“…As the demand to save and maintain natural teeth has increased, more endodontic procedures are being performed, with a consequent increased risk for failure of root canal therapy or retreatment, and periradicular endodontic surgery. The success rate of endodontic surgery in the literature ranges from 59.1 to 96.8% [28,29]. Most failures were due to inadequate root canal sealing.…”

Section: Discussionmentioning

confidence: 99%

Micro-computed tomography-based anatomical study of the branch canals in mandibular anterior teeth in a Chinese population

2018

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Endodontics, Endodontic Retreatment, and Apical Surgery Versus Tooth Extraction and Implant Placement: A Systematic Review

Cited by 71 publications

References 60 publications

Anti‐inflammatory and immunomodulatory effects of Biodentine on human periapical lesion cells in culture

Anti‐inflammatory and immunomodulatory effects of Biodentine on human periapical lesion cells in culture

Tratamiento de lesión periapical con obturación retrógrada e injerto óseo. Reporte de un caso

Micro-computed tomography-based anatomical study of the branch canals in mandibular anterior teeth in a Chinese population

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