We assessed the impact of type of tooth on the outcome of root canal treatment (RCT) according to factors potentially weakening the prognosis such as preoperative apical periodontitis (AP) and treatment modality (primary or secondary RCT). Materials and Methods: We scrutinized patient documents including pre-and post-operative radiographs of 640 permanent teeth receiving non-surgical RCT at Helsinki University Clinic in 2008-2011. Of teeth, 44% were molars, 32% premolars and 24% anteriors. Patients' mean age was 51.5 years, 51% were male. AP was present in 60.5% of teeth preoperatively. We used the Periapical Index (PAI) to assess the radiographs and defined radiographically "healthy" and "healing" cases as successful. Statistical evaluation included Chi-squared tests, Fisher´s exact tests, t-tests and logistic regression modelling. Results: The overall success rate (SR) was 84.1%; 88.3% for primary and 75.5% for secondary RCT (p < 0.001). The SRs for anteriors, premolars and molars were 85.6%, 88.8% and 79.7%, respectively.