Endodontic Chelators Induce Nitric Oxide Expression by Murine-cultured Macrophages

Pappen, Fernanda Geraldo; Souza, Erick Miranda; Giardino, Luciano; Carlos, Iracilda Z.; Leonardo, Mário Roberto; Leonardo, Renato de Toledo

doi:10.1016/j.joen.2009.03.002

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…This result is in agreement with Pappen et al (2009) who reported a significant proinflammatory effect of Tween 80, which was thought to be due to growth inhibition and a cytotoxic response. In the absence of H 2 O 2 , the loss of cell viability, membrane damage, and nitric oxide production at microemulsions concentrations above 0.0313%, indicated that the Tween 80 was probably a key factor leading to cytotoxicity and that the concentrations of β-carotene incorporated into the microemulsion system were not sufficient to significantly ameliorate cytotoxicity (Fig.…”

Section: Discussionsupporting

confidence: 93%

Capacity of natural β-carotene loaded microemulsion to protect Caco-2 cells from oxidative damage caused by exposure to H2O2

Roohinejad

Middendorf

Burritt

et al. 2014

Food Research International

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Section: Discussionsupporting

confidence: 93%

Capacity of natural β-carotene loaded microemulsion to protect Caco-2 cells from oxidative damage caused by exposure to H2O2

Roohinejad

Middendorf

Burritt

et al. 2014

Food Research International

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“…However, the effect of irrigation solutions on the periapical immune response, specifically cytokine secretion, is not clear. 6,22,23 IL-1 and TNF-α are important inflammatory cytokines which proide bone destruction induction during periapical diseases recovery. 24 Besides these two cytokines, VEGF is an angiogenetic cytokine which can enhance the regeneration potential of periapical surronding tissues.…”

Section: Discussionmentioning

confidence: 99%

Effect of various irrigation solutions on cytokine expression of human gingival fibroblast: in vitro study

Aydın¹,

Akpınar²,

Hepokur³

et al. 2019

Yeditepe J Dent

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The aim of this study is to investigate the release of IL-1, TNFα and VEGF following administration of NaOCl, propolis and chitosan solutions on human gingival fibroblasts. Materials and Methods: This study was conducted on human fibroblast by cell culture and evaluation of the direct effect of various solutions on the cultured cells. The release of pro-inflammatory interleukin (IL), tumor necrosis factor (TNF) α and vascular endothelial growth factor (VEGF) on fibroblast was analyzed after administration of irrigation solutions. Log concentrations of NaOCl, Propolis and Chitosan effects on cells were measured by colorimetric method. Results: IL-1 and TNF-α secretion levels decreased during propolis and chitosan applications, which are natural products. It was also found that the propolis increased VEGF secretion more than the other materials. Conclusions: The results of this study suggest that propolis and chitosan may contribute to the recovery of periapical tissues via anti-inflammatory cytokines level secreted during the inflammatory process. It is important to search for the biological effect of the materials in contact with the direct or indirect cause of the surrounding tissues during the endodontic treatment.

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“…Both researches concluded that citric acid was the least irritating solution, either because this acid yielded the lowest amount of extracted dye (13) or because it presented the lowest inflammatory cells count ( Table 1). The low cytotoxicity of citric acid could be explained by its lower proinflammatory effect when compared with EDTA-based solutions, which was because of the lower nitric oxide concentrations displayed by the citric acid-containing solutions (28). Furthermore, when it comes to human cells, citric acid plays an important role in the tricarboxylic acid cycle, which is crucial to the regulation of energy homeostasis and cell metabolism (29).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Inflammatory Response of EDTA, EDTA-T, and Citric Acid in Animal Model

Scelza

Pierro

Chagas

et al. 2010

Journal of Endodontics

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Endodontic Chelators Induce Nitric Oxide Expression by Murine-cultured Macrophages

Cited by 8 publications

References 40 publications

Capacity of natural β-carotene loaded microemulsion to protect Caco-2 cells from oxidative damage caused by exposure to H2O2

Capacity of natural β-carotene loaded microemulsion to protect Caco-2 cells from oxidative damage caused by exposure to H2O2

Effect of various irrigation solutions on cytokine expression of human gingival fibroblast: in vitro study

Evaluation of Inflammatory Response of EDTA, EDTA-T, and Citric Acid in Animal Model

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