Endodermal Sinus Tumor of Vagina in Infants

Abstract

Endodermal sinus tumor (or Yolk Sac tumor) of the vagina is a rare malignant germcell tumor which is seen exclusively in children younger than 3 years of age. We report two cases of endodermal sinus tumor of the vagina. In both cases no radiological investigation was done and serum alpha-fetoprotein was elevated. The histopathological examination of both the tumor masses revealed vaginal endodermal sinus tumor. Periodic-acid-Schiff stain with diastase showed diastase resistant hyaline globules. These findings confirmed the diagnosis of endodermal sinus tumor in both cases. Vaginal endodermal sinus tumor is both locally aggressive and capable of metastasis. The serum alpha-fetoprotein level is a useful marker for diagnosis and monitoring the recurrence of vaginal endodermal sinus tumor in infants. Early detection and therapy is important because of its aggressive nature and good response to chemotherapy.

Primary Yolk Sac Tumor in the Cerebellar Hemisphere: A Case Report and Literature Review of the Rare Tumor

“…Many studies have reported that YST occurs in the vagina, seminal vesicle, pancreas, omentum and stomach, as well as in the intracranial and sacrococcygeal regions (2,3,(16)(17)(18)(19)(20)(21)(22)(23). GCTs originating in the intracranial region almost always occur in the suprasellar regions or pineal gland, but tumors in the cerebellar hemisphere are extremely rare (2).…”

Yolk sac tumor of vagina: a rare cause of vaginal bleeding in adolescents-a case report

“…The clinical presentation includes a history of bloody vaginal discharge, often accompanied by a polypoid mass protruding from the vagina which was not the case in our patient. Most common differential diagnosis is botyroides sarcoma differentiated by its characteristic grape like appearance and histopathology [ 4 ]. The use of serum AFP as tumor marker has been well established for patients with YST.…”

Prepubertal Vaginal Bleeding: An Inpatient Series from a Single Center in Fujian China

“…Vaginal yolk sac tumors occur mostly in children under 3 years of age. 13 The main symptoms are irregular vaginal bleeding and occasional tumor shedding from the vagina, accompanied by a significant increase in AFP. The sensitivity of vaginoscopy under anesthesia is 100% 14 ; therefore, for children with vaginal bleeding who are suspected of having vaginal tumors, vaginoscopy under anesthesia is recommended.…”