Endoderm Jagged induces liver and pancreas duct lineage in zebrafish

Gates, Keith P.; Barske, Lindsey; Wang, Guangliang; Lancman, Joseph J.; Zeng, Xin-Xin I.; Groff, Megan G.; Wang, Kasper; Parsons, Michael; Crump, J. Gage; Dong, Peng

doi:10.1038/s41467-017-00666-6

Cited by 29 publications

(41 citation statements)

References 71 publications

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“…For example, Serrate/Notch signaling functions in the cell specification of crystal cells in Drosophila larval lymph glands (Duvic et al 2002). Serrate/Notch signaling is also required for tubular tissue specification in vertebrates: Jagged, the vertebrate ortholog of Ser, induces the linage specification of liver and pancreas duct cells from progenitor cells (Zhang et al 2017). Additionally, we cannot completely rule out the possibility that Notch regulates cell proliferation during embryogenesis and the early larval stage.…”

Section: Notch Signaling In Early Imaginal Ring Developmentmentioning

confidence: 95%

Serrate/Notch Signaling Regulates the Size of the Progenitor Cell Pool inDrosophilaImaginal Rings

Yang¹,

Deng

2018

Genetics

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imaginal rings are larval tissues composed of progenitor cells that are essential for the formation of adult foreguts, hindguts, and salivary glands. Specified from subsets of ectoderm in the embryo, imaginal ring cells are kept quiescent until midsecond larval instar, and undergo rapid proliferation during the third instar to attain adequate numbers of cells that will replace apoptotic larval tissues for adult organ formation. Here, we show that Notch signaling is activated in all three imaginal rings from middle embryonic stage to early pupal stage, and that Notch signaling positively controls cell proliferation in all three imaginal rings during the third larval instar. Our mutant clonal analysis, knockdown, and gain-of-function studies indicate that canonical Notch pathway components are involved in regulating the proliferation of these progenitor cells. Both -activation and-inhibition between the ligand and receptor control Notch activation in the imaginal ring. Serrate (Ser) is the ligand provided from neighboring imaginal ring cells that -activates Notch signaling, whereas both Ser and Delta (Dl) could-inhibit Notch activity when the ligand and the receptor are in the same cell. In addition, we show that Notch signaling expressed in middle embryonic and first larval stages is required for the initial size of imaginal rings. Taken together, these findings indicate that imaginal rings are excellent models to decipher how progenitor cell number and proliferation are developmentally regulated, and that Notch signaling in these imaginal tissues is the primary growth-promoting signal that controls the size of the progenitor cell pool.

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Section: Notch Signaling In Early Imaginal Ring Developmentmentioning

confidence: 95%

Serrate/Notch Signaling Regulates the Size of the Progenitor Cell Pool inDrosophilaImaginal Rings

Yang¹,

Deng

2018

Genetics

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“…For example, the JAG1-NOTCH2 signaling axis has been widely known for its role in biliary specification and morphogenesis [7,8,9,10,11]. However, studies in vertebrate model organisms indicate that other Notch receptors and ligands also contribute to bile duct development [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…In the liver, which is the subject of the current work, Notch signaling is important for the proper development of the biliary tree. This is evidenced by the bile duct paucity caused by JAG1 and NOTCH2 mutations in human patients with Alagille syndrome (ALGS) and the biliary abnormalities observed in vertebrate animal models with reduced Notch signaling [7,8,9,10,11,13,14,15,16,17]. The Notch pathway is also involved in liver regeneration and repair, liver fibrosis and metabolism [18].…”

Section: Introductionmentioning

confidence: 99%

The Roles of Notch Signaling in Liver Development and Disease

Adams

Jafar‐Nejad

2019

Biomolecules

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The Notch signaling pathway plays major roles in organ development across animal species. In the mammalian liver, Notch has been found critical in development, regeneration and disease. In this review, we highlight the major advances in our understanding of the role of Notch activity in proper liver development and function. Specifically, we discuss the latest discoveries on how Notch, in conjunction with other signaling pathways, aids in proper liver development, regeneration and repair. In addition, we review the latest in the role of Notch signaling in the pathogenesis of liver fibrosis and chronic liver disease. Finally, recent evidence has shed light on the emerging connection between Notch signaling and glucose and lipid metabolism. We hope that highlighting the major advances in the roles of Notch signaling in the liver will stimulate further research in this exciting field and generate additional ideas for therapeutic manipulation of the Notch pathway in liver diseases.

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“…Bile fluid is drained to a network of intrahepatic bile ducts that is connected to extrahepatic bile duct. Zebrafish has been used to model cholestatic liver diseases, including progressive familial intrahepatic cholestasis type 2 (PFIC2) [4], Alagille syndrome [5, 6], biliary atresia [7–13], arthrogryposis-renal dysfunction-cholestasis syndrome [14, 15], North American Indian childhood cirrhosis [16], and choledochal cysts [17]. Some of these zebrafish models overcome the limitations of the in vitro systems and rodent models and have brought new knowledge to the disease pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Zebrafish as a Model to Study Cholestatic Liver Diseases

Pham

Yin

2019

Methods in Molecular Biology

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Cholestasis is a condition that impairs bile flow, resulting in retention of bile fluid in the liver. It may cause significant morbidity and mortality due to pruritus, malnutrition, and complications from portal hypertension secondary to biliary cirrhosis. The zebrafish (Danio rerio) has emerged as a valuable model organism for studying cholestasis that complements with the in vitro systems and rodent models. Its main advantages include conserved mechanisms of liver development and bile formation, rapid external development, ease of monitoring hepatobiliary morphology and function in live larvae, and accessibility to genetic and chemical manipulations. In this chapter, we provide an overview of the existing zebrafish models of cholestatic liver diseases. We discuss the strengths and limitations of using zebrafish to study cholestasis. We also provide step-by-step descriptions of the methodologies for analyzing cholestatic phenotypes in zebrafish.

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Endoderm Jagged induces liver and pancreas duct lineage in zebrafish

Cited by 29 publications

References 71 publications

Serrate/Notch Signaling Regulates the Size of the Progenitor Cell Pool inDrosophilaImaginal Rings

Serrate/Notch Signaling Regulates the Size of the Progenitor Cell Pool inDrosophilaImaginal Rings

The Roles of Notch Signaling in Liver Development and Disease

Zebrafish as a Model to Study Cholestatic Liver Diseases

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