Endocytic mechanism of macrophages to anionic foreign substances.

An experimental study on the pathway of iron transfer from macrophages to erythrocytes in rat liver.

“…As reported previously, anionic Fe-PVS particles injected intravenously were phagocytized solely by macrophages of the reticuloendothelial system (21,22), and ferritin was synthesized within a few days (20). Thus, Fe-PVS is a useful tool for the study of ferritin synthesis in macrophages and the subsequent iron release.…”

Endocytosis of cationic iron colloid particles by rat peritoneal macrophages and the ferritin synthesis. A morphological study.

“…In the previous study (9,10), we demonstrated that the anionic iron colloid particles were solely taken up by macrophages. The particles first bound to the cationic groups or receptors on the cell surface, and were then taken into the cytoplasm by phagocytic process resulting in the marked swelling of cells.…”