Endocytic Accessory Factors and Regulation of Clathrin-Mediated Endocytosis

Merrifield, Christien J.; Kaksonen, Marko

doi:10.1101/cshperspect.a016733

Cited by 114 publications

(112 citation statements)

References 125 publications

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“…The nonstructural proteins (i.e., those largely excluded from the budded coated vesicle) appear at varying levels relative to clathrin during the lifetime of a coated pit (see Merrifield and Kaksonen 2014 assembly; others such as dynamin, synaptojanin, and auxillin, which participate in vesicle pinching and uncoating, appear in substantial quantities only at subsequent stages.…”

Section: Nonstructural Proteinsmentioning

confidence: 99%

“…Clathrin coat assembly at the plasma membrane requires both recruitment of clathrin by lipid-associated adaptor proteins and cooperativity of lattice interactions. The nonstructural proteins, collectively termed endocytic accessory proteins, ensure efficient coated-pit assembly, cargo recruitment, and prompt coat disassembly after budding (see Traub and Bonifacino 2013;Merrifield and Kaksonen 2014).…”

Section: Nonclathrin Protein Components In the Coatmentioning

confidence: 99%

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Molecular Structure, Function, and Dynamics of Clathrin-Mediated Membrane Traffic

Kirchhausen

Owen

Harrison

2014

Cold Spring Harbor Perspectives in Biology

412

442

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Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. This review describes the structures of clathrin, major cargo adaptors, and other proteins that participate in forming a clathrin-coated pit, loading its contents, pinching off the membrane as a lattice-enclosed vesicle, and recycling the components. It integrates as much of the structural information as possible at the time of writing into a sketch of the principal steps in coated-pit and coated-vesicle formation.

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Section: Nonstructural Proteinsmentioning

confidence: 99%

Section: Nonclathrin Protein Components In the Coatmentioning

confidence: 99%

Molecular Structure, Function, and Dynamics of Clathrin-Mediated Membrane Traffic

Kirchhausen

Owen

Harrison

2014

Cold Spring Harbor Perspectives in Biology

412

442

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“…Animal cells take up solutes, nutrients, ligands, and components of the plasma membrane via multiple endocytic pathways, which all merge in common early endosomes (Mayor and Pagano 2007;Doherty and McMahon 2009;Donaldson et al 2013;Johannes et al 2013;Kirchhausen et al 2013;Merrifield and Kaksonen 2013). There, cargo can be sorted to different cellular destinations, including the plasma membrane, the trans-Golgi network (TGN), or late endosomes.…”

Section: Organization Of the Endosomal Pathwaymentioning

confidence: 99%

Lipid Sorting and Multivesicular Endosome Biogenesis

Bissig

Grüenberg

2013

Cold Spring Harbor Perspectives in Biology

128

107

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Intracellular organelles, including endosomes, show differences not only in protein but also in lipid composition. It is becoming clear from the work of many laboratories that the mechanisms necessary to achieve such lipid segregation can operate at very different levels, including the membrane biophysical properties, the interactions with other lipids and proteins, and the turnover rates or distribution of metabolic enzymes. In turn, lipids can directly influence the organelle membrane properties by changing biophysical parameters and by recruiting partner effector proteins involved in protein sorting and membrane dynamics. In this review, we will discuss how lipids are sorted in endosomal membranes and how they impact on endosome functions.

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“…We begin with several articles that describe our current understanding of the molecular machinery and mechanisms driving entry of cargo (e.g., receptors and bound ligands) into the cell, by clathrin-dependent and -independent endocytosis (Traub and Bonifacino 2013;Kirchhausen et al 2014;Mayor et al 2014;Merrifield and Kaksonen 2014;Mettlen and Danuser 2014). Following internalization, the endocytosed material is shuttled along an ultrastructurally complex and dynamic pathway of tubular and vesicular compartments collectively known as endosomes, and described in the article by Klumperman and Raposo (2014), from which they can be sorted for recycling back to the cell surface or delivered to lysosomes for degradation.…”

Section: Overview Of Articlesmentioning

confidence: 99%