Endocrinology of parturition in the pig

Ellendorff, Franz; Taverne, M.A.M.; Elsaesser, Folkmar; Forsling, Mary L.; Parvizi, Nahid; Naaktgeboren, C.; Smidt, Diedrich

doi:10.1016/0378-4320(79)90056-3

Cited by 44 publications

(21 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In short, the onset of nest-building seems to be triggered by a rise in prolactin level Castrén et al, 1993). This rise itself is induced by a decrease in progesterone and an increase in prostaglandin (Ellendorff et al, 1979;Burne et al, 2001b;Algers and Uvnäs-Moberg, 2007). Nest-building behaviour can be induced by the administration of prostaglandin PGF 2α injections in pregnant sows (Widowski and Curtis, 1989).…”

Section: Influences On Nest-building Performancementioning

confidence: 97%

Nest-building behaviour in sows and consequences for pig husbandry

2009

View full text Add to dashboard Cite

Section: Influences On Nest-building Performancementioning

confidence: 97%

Nest-building behaviour in sows and consequences for pig husbandry

2009

View full text Add to dashboard Cite

“…Parturition in the pig is preceded by changes in peripheral plasma concentrations of hormones originating from the ovaries (progesterone, relaxin), the placentas (oestrogens) and the maternal hypophysis (prolactin; reviews by Ellendorff et al, 1979b: First & Bosc, 1979Taverne, 1979). A decline in progesterone concentrations (Robertson & King, 1974;Ash & Heap, 1975), caused by the regression of the corpora lutea, seems to play an essential role in the onset of parturition because progesterone treatment after ovariectomy prevents premature delivery of piglets (First & Staigmiller, 1973), and induction of additional corpora lutea on Days 103 or 107 of pregnancy prolongs gestation (Bosc, du Mesnil du Buisson & Locatelli, 1974;Martin, Norton & Dziuk, 1977).…”

Section: Introductionmentioning

confidence: 99%

Plasma concentrations of prolactin, progesterone, relaxin and oestradiol-17 in sows treated with progesterone, bromocriptine or indomethacin during late pregnancy

Taverne¹,

Bevers²,

Bradshaw³

et al. 1982

Reproduction

Self Cite

View full text Add to dashboard Cite

Pregnant gilts (3/group) were given no treatment, 10 mg bromocriptine twice daily by mouth, from Day 111 of pregnancy to 1 day post partum, 25 mg progesterone s.c. at 6-h intervals from Days 111 to 116 inclusive or 400 mg indomethacin by mouth at 6-h intervals from Day 111 to 116 inclusive. Before spontaneous delivery maternal plasma prolactin and relaxin concentrations started to rise almost simultaneously between 58 and 47 h before the first piglet and both hormones reached peak values when the plasma progesterone concentration had started to decline rapidly (approximately 21-23 h). Suppression of prolactin levels by bromocriptine prevented the onset of lactation completely but had no obvious influence on changes of the other hormone concentrations and the course of parturition. Progesterone treatment delayed the onset of expulsion of the piglets but did not delay the simultaneous increase in prolactin and relaxin concentrations. These changes in hormone levels were prevented by indomethacin treatment but occurred essentially unchanged when the treatment was ended. The results support the concept that parturition in the pig is preceded by a biphasic increase of plasma prostaglandin levels.

show abstract

“…Journal ofEndocrinology (1990) 124, 475\p=n-\484 Stabenfeldt, 1975; Silver, Barnes, Comline er a/. 1979), and rapid increases in prolactin (Taverne, Willemse, Dieleman & Bevers, 1978/79;Ellendorff, Taverne, Elsaesser et al 1979), prostaglandin (PG) (Silver et al 1979) and relaxin (Sherwood, Nara, Crnekovic & First, 1979). Attempts to achieve control of farrowing time in sows in late pregnancy have usually involved INTRODUCTION Previous studies have shown that parturition in the sow is preceded by a decline in maternal circulating concentrations of progesterone (Robertson & King, 1974;Ash & Heap, 1975), gradual rises in oestrogens (Ash & Heap, 1975) and glucocorticoids (Baldwin & endocrine manipulation, including the use of PG (Diehl, Godke, Killian & Day, 1974;Willemse, Taverne, Roppe & Adams, 1979), PG in conjunction with oxytocin (Welk & First, 1979), progesterone or meclofenamic acid followed by PG (Gooneratne, Hartmann, McCauley & Martin, 1979;Gooneratne, Hartmann & Barker, 1982), or oral progestagens such as allyl trenbolone to sows in late pregnancy (Kirkwood, Moller, Smith et al 1985).…”

mentioning

confidence: 96%

Initiation of parturition and lactation in the sow: effects of delaying parturition with medroxyprogesterone acetate

Whitely

Hartmann²,

Willcox³

et al. 1990

Journal of Endocrinology

View full text Add to dashboard Cite

The synthetic progestagen, medroxyprogesterone acetate (MPA), was administered to sows in late pregnancy with the objective of slightly delaying the time of farrowing and thereby providing more marked associations between hormonal changes and the termination of pregnancy, and the initiation of farrowing and lactation in this species. MPA was administered orally (140 mg, twice daily) to eight sows in late pregnancy on days 112, 113 and 114 of gestation. Parturition was then induced to occur on day 116 by injecting 200 micrograms cloprostenol i.m. on day 115 of gestation. The peripartum changes in the plasma concentrations of progesterone, cortisol, oestradiol-17 beta, relaxin, prolactin, lactose and 13,14-dihydro-15-keto prostaglandin F2 alpha (PGFM) were measured in these sows together with a group of untreated sows. The gestational length for the MPA-treated sows (116.3 +/- 0.3 days, mean +/- S.E.M.) was significantly (P less than 0.01) greater compared with the untreated sows (114.9 +/- 0.3 days). Plasma progesterone declined earlier (P less than 0.05) with respect to the time of parturition in the treated sows compared with the untreated group. With respect to the timing of parturition, the time at which maximal concentrations of relaxin were attained and the timing of the subsequent decline were earlier in the MPA-treated sows. In both groups of sows, the concentration of relaxin increased before the decline in plasma progesterone. In the untreated sows, the concentration of PGFM increased either slightly before or at the same time as the decline in plasma progesterone, whereas in sows treated with MPA, progesterone concentrations began to decline before any significant increase in the plasma concentration of PGFM. The profiles of cortisol, oestradiol-17 beta and PGFM were similar in both groups of sows. In both groups of sows, the timing of the initial increase in the concentration of plasma prolactin coincided with a similar rise in plasma lactose (P less than 0.01). Plasma progesterone either declined earlier or at the same time as the rise in plasma lactose (P less than 0.01) in the treated group of sows only. We conclude that since the prepartum changes in the concentration of progesterone and relaxin occurred before significant changes in the concentration of PGFM in the MPA-treated sows, the nature of the luteolytic factor and the mechanism by which it exerts its action remains obscure. The higher concentration of lactose in the mammary secretion at birth in the MPA-treated sows compared with the untreated group suggested that lactogenesis was initiated earlier with respect to parturition following MPA treatment.(ABSTRACT TRUNCATED AT 400 WORDS)

show abstract

Endocrinology of parturition in the pig

Cited by 44 publications

References 31 publications

Nest-building behaviour in sows and consequences for pig husbandry

Nest-building behaviour in sows and consequences for pig husbandry

Plasma concentrations of prolactin, progesterone, relaxin and oestradiol-17 in sows treated with progesterone, bromocriptine or indomethacin during late pregnancy

Initiation of parturition and lactation in the sow: effects of delaying parturition with medroxyprogesterone acetate

Contact Info

Product

Resources

About