Endocrine tumors and peptic ulcer

Some effects of hypophysectomy on gastrointestinal function and structure

“…The dependence of gastric mucosal structure and function on hormonal activity has been the subject of many investigations (Welbourn and Ward, 1962;Zollinger and Craig, 1960;Grossman, 1950). The conflicting nature of experimental findings and interpretations, particularly as related to the effect of adrenal cortical hormones on gastric secretion, is reflected in many articles reviewing this subject (Bachrach, 1963;Sulman and Kirsner, 1963;Smith, Delamore and Williams, 1961;Clarke, Neill, and Welbourn, 1960;Wiederanders, Classen, Gobbel, and Doyle, 1960;Gray, 1957;Kirsner, 1957).…”

A Case of the Zollinger-Ellison Syndrome with Associated Splenomegaly

“…This patient illustrates well the recurrence of ulcer symptoms, and the persistence of hyperacidity after routine gastric resection, which are features of the Zollinger-Ellison syndrome (Zollinger and Ellison, 1955).…”

Pluriglandular Syndrome

“…R ec e n tly , Gray, Zollinger, K irsn er, a n d others [15,35], in a pan el discussion o f a sym p o siu m on ad en o m as o f endocrine glands an d p ep tic ulcer, em phasized th e possib ility o f increased secretion o f a n o rm al h o rm o n e, p ro b a b ly com ing from one source, such as th e p itu ita ry an d in influencing o th e r g lan d s an d o rg an system s. Russfield, Fischer a n d o th e rs [15,35], suggested th a t th e re m ig h t be a tro p h ic horm one, p u t o u t b y th e am p h o p h ilic or b asophilic cells o f th e p itu ita ry , w hich increases th e a c tiv ity of o th e r en d o crine system s ( Gray [35]). R u ss fie ld et al [19] p o stu la te d th a t end o rgan failure o f c ertain ta rg e t en docrine o rg an s su ch as th e g onads or en d o m etriu m leads to h y p e r p lasia o f th e am p h o p h ilic or b aso p h ilic cells o f th e p itu ita ry .…”

“…N u m ero u s stu d ie s in an im als given a n te rio r p itu ita ry e x tra c t, have described an increase in th e size a n d w eight of th e p a ra th y ro id g lan d s" [13,25,26]. T h e p a rtic u la r in te re s t in th ese cases cen ters a b o u t th e fa c t t h a t th e p a ra th y ro id a n d p itu ita ry glands seem to be intim atelyre la te d in p ro d u cin g g a stro in te stin a l lesions, w hereas islet-cell tu m o rs are in d e p e n d e n tly an d solely in c rim in a te d in pro d u cin g p ep tic ulcers (Z ollinger-E llison sy ndrom e) [15,27].…”

“…re la te d to ad en o m ato sis o f th e en d o crine glands. A lth o u g h th e tru e incidence o f endo crin e-in d u ced p e p tic ulcer is u n know n (Zollinger [15]), m a n y a u th o rs fav o r th is in te rre la tio n sh ip .…”