Endocrine Studies in Patients With Pseudotumor Cerebri

Sørensen, Per Soelberg; Gjerris, F.; Svenstrup, Birgit

doi:10.1001/archneur.1986.00520090038013

Cited by 44 publications

(11 citation statements)

References 42 publications

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“…The predilection of the disease for a particular gender would suggest that hormones may play a role in pathogenesis; however, previous studies into the role of oestrogens were inconclusive and have not been replicated. 14,15 It may be that the class of hormones that need further investigation are the androgens, as highlighted by this case report and the previous cases (Table 1), coupled with the observation that another androgen dysregulated condition, PCOS, shares a strikingly similar clinical phenotype. Furthermore, one study reports an increased incidence (58%) of PCOS in FTM patients prior to hormonal therapy.…”

Section: Discussionmentioning

confidence: 55%

What Do Transgender Patients Teach Us About Idiopathic Intracranial Hypertension?

Hornby

Mollan

Mitchell

et al. 2017

Neuro-Ophthalmology

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Idiopathic intracranial hypertension (IIH), a condition of raised intracranial pressure, is characterised by headaches and visual disturbances. Its pathogenesis is currently unknown; however, dysregulation of androgens may be implicated. Here, the authors present a case of a 22-year-old patient undergoing female-to-male (FTM) gender reassignment who developed IIH shortly after commencing testosterone therapy. This interesting case presents the possibility of androgens having a pathogenic role in IIH.

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Section: Discussionmentioning

confidence: 55%

What Do Transgender Patients Teach Us About Idiopathic Intracranial Hypertension?

Hornby

Mollan

Mitchell

et al. 2017

Neuro-Ophthalmology

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“…In the CSF of both male and female adult patients with PTCS, estrone levels are increased while androstenedione levels are decreased (ref. (55,56) but see (57), differences not seen in plasma (55) and suggestive of a localized increase in aromatase activity. Indeed, exposure to exogenous (Levonorgestrel (58) and emergency contraceptives (59)) and endogenous (pregnancy (60,61) and polycystic ovarian syndrome (62)) estrogens have all been associated with PTCS.…”

Section: Association Of Ptcs and Endocrinopathiesmentioning

confidence: 89%

An integrated mechanism of pediatric pseudotumor cerebri syndrome: evidence of bioenergetic and hormonal regulation of cerebrospinal fluid dynamics

et al. 2014

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Pseudotumor cerebri syndrome (PTCS) is defined by the presence of elevated intracranial pressure (ICP) in the setting of normal brain parenchyma and cerebrospinal fluid (CSF). Headache, vision changes, and papilledema are common presenting features. Up to 10% of appropriately treated patients may experience permanent visual loss. The mechanism(s) underlying PTCS is unknown. PTCS occurs in association with a variety of conditions, including kidney disease, obesity, and adrenal insufficiency, suggesting endocrine and/or metabolic derangements may occur. Recent studies suggest that fluid and electrolyte balance in renal epithelia is regulated by a complex interaction of metabolic and hormonal factors; these cells share many of the same features as the choroid plexus cells in the central nervous system (CNS) responsible for regulation of CSF dynamics. Thus, we posit that similar factors may influence CSF dynamics in both types of fluid-sensitive tissues. Specifically, we hypothesize that, in patients with PTCS, mitochondrial metabolites (glutamate, succinate) and steroid hormones (cortisol, aldosterone) regulate CSF production and/or absorption. In this integrated mechanism review, we consider the clinical and molecular evidence for each metabolite and hormone in turn. We illustrate how related intracellular signaling cascades may converge in the choroid plexus, drawing on evidence from functionally similar tissues.

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“…Predominantly found in women after menarche, this condition can be recurrent with menses or with pregnancy [2-4], or associated with menstrual irreg ularity. Fluctuations in estrogen, progesterone and pro lactin levels have been linked to its occurrence [4][5][6]. We now report a 15-year-old girl who developed pseudotu mor 2 weeks after eclampsia.…”

mentioning

confidence: 86%

Pseudotumor Cerebri following Eclampsia

1990

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Pseudotumor cerebri, or increased intracranial pressure without a mass lesion, has been associated with hormonal activity but the exact causative relation is still obscure. We report a case of a 15-year-old girl who developed pseudotumor cerebri manifested by headache, visual symptoms and extraocular muscle palsies 3 weeks after recovering from eclampsia. Possible associations with eclampsia and postpartum changes in estrogen, progesterone and prolactin are discussed.

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Endocrine Studies in Patients With Pseudotumor Cerebri

Cited by 44 publications

References 42 publications

What Do Transgender Patients Teach Us About Idiopathic Intracranial Hypertension?

What Do Transgender Patients Teach Us About Idiopathic Intracranial Hypertension?

An integrated mechanism of pediatric pseudotumor cerebri syndrome: evidence of bioenergetic and hormonal regulation of cerebrospinal fluid dynamics

Pseudotumor Cerebri following Eclampsia

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