Endocrine response to acute cold exposure by lactating and non-lactating norway rats

Adels, Lori; Leon, Michael; Wiener, Sandra G.; Smith, M. Susan

doi:10.1016/0031-9384(86)90093-4

Cited by 14 publications

(6 citation statements)

References 13 publications

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“…It often has a suppressive effect on immune function (Sapolsky et al, 2000;Webster Marketon and Glaser, 2008). In the present study, corticosterone concentration was affected significantly by the interaction cold stress×food restriction, but not by cold stress or food restriction, which is incompatible with other research in which corticosterone levels increased under conditions of cold stress (Adels et al, 1986;Shu et al, 1993) or food restriction (Murphy and Wideman, 1992;Demas and Nelson, 1998;Bilbo and Nelson, 2004). Furthermore, other studies found that food restriction decreased the levels of cortisol (Zysling et al, 2009) or corticosterone .…”

Section: Discussioncontrasting

confidence: 96%

Effect of temperature and food restriction on immune function in striped hamsters (Cricetulus barabensis)

Tian

2017

Journal of Experimental Biology

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Small mammals in temperate areas face seasonal fluctuations of temperature and food availability, both of which may influence their immune responses, which are critical to survival. In the present study, we tested the hypothesis that low temperature and food restriction suppress immune function in striped hamsters (Cricetulus barabensis). Thirty-seven adult male hamsters were randomly assigned to warm (23±1°C) and cold (5±1°C) treatment groups, which were further divided into fed and food-restricted groups. Body mass was not affected by cold stress, food restriction or the interaction cold stress×food restriction. Cold stress decreased total body fat mass, haematological parameters including white blood cells, lymphocytes and neutrophilic granulocytes, and immunoglobin (Ig) M titres 5 days after injecting keyhole limpet haemocyanin (KLH). However, cold temperature increased bacterial killing capacity, indicative of innate immunity, and did not affect the mass of the thymus and spleen, intermediate granulocytes, the phytohaemagglutinin (PHA) response and the levels of blood glucose and serum leptin. Corticosterone concentration was affected significantly by the interaction cold stress×food restriction but not by cold stress or food restriction alone. Food restriction reduced thymus mass, but other immunological parameters including body fat mass, spleen mass, haematological parameters, innate immunity, PHA response, the titres of IgM and IgG, and the levels of blood glucose and serum leptin were all not affected by food restriction or the interaction cold stress×food restriction. Innate immunity was positively correlated with leptin levels, whereas no significant correlations were observed in the levels of blood glucose, serum leptin, corticosterone and all the detected immune parameters. Our results show that cold stress suppressed humoral immunity but enhanced innate immunity and did not affect cellular immunity in striped hamsters. Most immunological indices were not influenced by food restriction. Blood glucose, leptin and corticosterone could not explain the changes of innate, cellular and humoral immunity upon cold stress or food restriction in striped hamsters.

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Section: Discussioncontrasting

confidence: 96%

Effect of temperature and food restriction on immune function in striped hamsters (Cricetulus barabensis)

Tian

2017

Journal of Experimental Biology

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“…Previous studies have shown that hormonal stress res ponses are reduced in lactating rats [1,37]. In one of these studies [37] evidence was presented, indicating that elevated circulating levels of PRL may be a causative factor in the reduction of stress responsiveness in the same way that hyperprolactinaemia is associated with analgesia [13,31].…”

Section: Discussionmentioning

confidence: 90%

Oxytocin Responses to Stress in Lactating and Hyperprolactinaemic Rats

Carter

Lightman²

1987

Neuroendocrinology

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The plasma oxytocin (OT) response to acute stress was compared between virgin, lactating, and hyperprolactinaemic female rats. In virgin rats, brief immobilization was associated with a significant elevation of plasma OT to 24.7 ± 3.7 pmol/l compared with 7.7 ± 1.1 pmol/l in controls. In contrast, the stress response was absent in lactating (6 days post-partum) animals: control OT 9.4 ± 2.2, immobilized OT 9.0 ± 1.1 pmol/l. Hyperprolactinaemia produced by treatment with either dopamine antagonists (domperidone or haloperidol) or ovine prolactin was also associated with an impairment of the OT stress response in intact females, whereas domperidone treatment failed to modify the response in ovariectomized (OVX) rats. Following ovarian steroid replacement with oestradiol and progesterone, the inhibitory effect of domperidone was observed in OVX rats: control OT 11.1 ± 2.5, immobilized OT 16.0 ± 3.7 pmol/l. Treatment of OVX rats with oestradiol and progesterone, either separately or combined, did not modify the OT stress response. Plasma levels of vasopressin were not significantly modified in either control or immobilized rats of any experimental groups. The results indicate that hyperprolactinaemia may be a causative factor in the impairment of OT stress responses observed in lactating rats.

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“…Lactation also blunts HPA axis reactivity to several stressors in rats including white noise [78], elevated plusmaze [79], forced swimming [79,80], acute cold exposure [81], and lipopolysaccharide injection [82]. Furthermore, corticosteroid response to ether stress is inversely related to litter size [83].…”

Section: Possible Mechanism Underlying Social Buffering Of the Hpa Axismentioning

confidence: 99%

Social modulation of stress responses

DeVries

Glasper

Detillion

2003

Physiology & Behavior

418

272

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Endocrine response to acute cold exposure by lactating and non-lactating norway rats

Cited by 14 publications

References 13 publications

Effect of temperature and food restriction on immune function in striped hamsters (Cricetulus barabensis)

Effect of temperature and food restriction on immune function in striped hamsters (Cricetulus barabensis)

Oxytocin Responses to Stress in Lactating and Hyperprolactinaemic Rats

Social modulation of stress responses

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