Endocrine Profile of Children with Intrauterine Growth Retardation

Fattal‐Valevski, Aviva; Toledano‐Alhadef, Hagit; Golander, Avraham; Leitner, Yael; Harel, Shaul

doi:10.1515/jpem.2005.18.7.671

Cited by 35 publications

(33 citation statements)

References 20 publications

(5 reference statements)

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“…Larger SGA and AGA groups may be needed in future studies. In contrast, in study carried out in Israel, 58 children aged 4-6 years with intrauterine growth retardation had a significantly increased BP compared with normal birth children (controls) [4]. Similarly, in a longitudinal study with children aged 5 through 21 years, birth weight was consistently inversely associated with SBP from childhood to young adulthood and to DBP in young adulthood [5].…”

Section: Discussionmentioning

confidence: 99%

“…Intrauterine growth restriction may also be responsible for the prenatal programming of BP. A number of studies have shown an association between low birth weight and higher BP in later life [4][5][6], but others did not provide support for fetal origin hypothesis as applied to BP regulation, reporting that the association between birth size and later blood pressure was not significant [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Ambulatory blood pressure monitoring and renal functions in term small-for-gestational age children

et al. 2010

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The aim of this study was to investigate the relationship between birth weight and blood pressure (BP) by means of ambulatory BP monitoring (ABPM) and renal functions in non-obese children who were born small-for-gestational age (SGA) at term. The study group consisted of 39 (19 female, 20 male; mean age 8.8 ± 2.6 years) children born SGA. Their data were compared to those of 27 (13 female, 14 male; mean age 8.2 ± 2.9 years) children born appropriate-for-gestational age (AGA). No difference between SGA and AGA children was observed based on office BP measurements and daytime, nighttime and 24-h ABPM. Seventeen SGA (48.6%) and nine AGA (37.5%) children had a 24-h systolic BP (SBP) load over 25%, and seven of these (5 SGA, 2 AGA) were hypertensive according to mean SBP values. The prevalence of the non-dipping phenomenon in SGA and AGA children was similar. Renal functions were normal and similar in both groups. Three children (2 SGA, 1 AGA) with normal glomerular filtration rate had higher microalbumin excretion and one SGA child had systolic hypertension according to the office BP. Our findings demonstrate that the influence of intrauterine growth restriction on BP is not manifested during the childhood period, and they do not support the existence of a negative relationship between birth weight and BP in children.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ambulatory blood pressure monitoring and renal functions in term small-for-gestational age children

et al. 2010

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“…Our data, for the first time in the literature, brings the combination of a detrimental situation induced by deficient diet with a non-expensive treatment, as the physical exercise to combat cardiac damage induced by a situation still present in our society, which is the undernutrition. There are epidemiological and clinical data supporting the hypothesis that poor quality of diet during developmental period increases the risk for several diseases including cardiovascular diseases 26,27 . In the opposite direction, hefty evidences have demonstrated that physical exercise counteracts the deleterious effect of several metabolic and cardiovascular diseases 14,28 .…”

Section: Discussionmentioning

confidence: 96%

Moderate physical training counterbalances harmful effects of low-protein diet on heart: metabolic, oxidative and morphological parameters

Carthagenes

Barreto

Freitas

et al. 2017

Motriz: rev. educ. fis.

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-Aims:Maternal low-protein diet induces several impairments on cardiac system. Conversely, moderate exercise has been widely recommended to health improvement due to its effects on heart function. Thus, we investigated whether the moderate physical training is capable to offset the lasting injuries of a maternal protein restriction on the hearts of male adult rats. Methods: Pregnant rats were divided into two groups: Control (C=17% casein) and undernutrition (U=8% casein). Offspring from the undernutrition group, at 60 days of life, were subdivided into undernutrition (U) and undernutrition+exercise (UT) groups. Treadmill exercise was performed: (8 weeks, 5 days/week, 60 min/day at 70% of VO2máx). 48 hours after last exercise session, tissues were collected for morphological and biochemical analysis. Results: Despite the deleterious effect induced by low-protein diet, physical training was able to restore morphological parameters to similar levels to the control group. Additionally, oxidative stress index was also improved in UT group, due to the increase in antioxidant enzymatic defense. In metabolic enzymes, maternal low-protein diet induced a change in metabolism, and moderate physical training improved oxidative metabolism. Conclusion: We demonstrated that moderate physical training can offset the cardiac metabolism in adult rats that were exposed to a maternal low-protein diet.

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“…Elevação na freqüência cardíaca em crianças prematuras e PIG quando comparadas com os controles foi observada por Johansson et al 21 . Outros estudos com crianças também demonstram essa associação, como os de Fattal-Valesvski et al 27 , Pereira et al 35 e Salgado et al 36 .…”

Section: Discussionunclassified

“…Após a leitura dos 14 artigos foram excluídos da análise 5. Os estudos de Rakow et al 10 , Bonamy et al 26 , Fattal-Valesvki et al 27 , De Rogalski et al 28 e Bergel et al 29 foram retirados da análise por não possuírem como objetivo a associação da pressão arterial com a idade gestacional.…”

Section: Metodologia Seleção De Artigosunclassified

Prematuridade como fator de risco para pressão arterial elevada em crianças: uma revisão sistemática

et al. 2011

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Estudos epidemiológicos têm sugerido que a hipertensão arterial é uma doença que tem início na infância e a prematuridade, crianças nascidas com menos de 37 semanas, um possível fator associado ao desenvolvimento deste agravo. Este estudo tem por objetivo identificar a associação entre prematuridade e elevação da pressão arterial em crianças por meio de revisão sistemática da literatura. Foram selecionados artigos das bases de dados MEDLINE, LILACS e SciELO publicados no período de 1998 a 2009. Excluiu-se os que não apresentavam resumo, redigidos em idioma diferente do inglês, português e espanhol e os que não objetivavam analisar a relação entre prematuridade e hipertensão. Foram analisados 9 artigos: 5 estudos de caso-controle, 2 transversais e 2 de coorte. Prematuridade não esteve associada à elevação da pressão arterial na infância na maioria dos artigos analisados, porém, sua influência não deve ser descartada, tendo em vista a pequena produção sobre o assunto, bem como as grandes diferenças metodológicas observadas nos estudos publicados no período analisado.

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Endocrine Profile of Children with Intrauterine Growth Retardation

Abstract: Lower cortisol levels in children born with IUGR may reflect impaired function of the hypothalamic-pituitary-adrenal axis associated with this condition. The significantly lower IGF-I levels of the 'non-catch-up' subgroup may be involved in their failure to grow.

Cited by 35 publications

References 20 publications

Ambulatory blood pressure monitoring and renal functions in term small-for-gestational age children

Ambulatory blood pressure monitoring and renal functions in term small-for-gestational age children

Moderate physical training counterbalances harmful effects of low-protein diet on heart: metabolic, oxidative and morphological parameters

Prematuridade como fator de risco para pressão arterial elevada em crianças: uma revisão sistemática

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