Endocrine/paracrine control of zebrafish ovarian development

Clelland, Eric; Peng, Chun

doi:10.1016/j.mce.2009.04.009

Cited by 231 publications

(114 citation statements)

References 124 publications

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“…Also, neuropeptide hormones called kisspeptins (kiss1 and kiss2) regulate the activity of GNRHreleasing neurons (Barb et al 2005, Gamba & Pralong 2006, Castellano et al 2009, Hausman et al 2012, consequently promoting the secretion of folliclestimulating hormone (Fsh) and luteinizing hormone (Lh). Fsh stimulates estradiol production, which in turn leads to a surge in Lh hormone levels, which, through its receptor (Lhcgr; Patino et al 2001, Clelland & Peng 2009), stimulates the production of maturation-inducing hormone and through its receptors (progestin and adipoQ receptor, namely Paqr7b and Paqr8) activate the oocyte maturation processes (Hanna & Zhu 2009). In addition, the transforming growth factor b (Tgfb) superfamily also plays a role in regulating oocyte maturation (Clelland et al 2006, Halm et al 2008, Clelland & Peng 2009, Lessman 2009, Tan et al 2009), which includes activin-A, bone morphogenetic protein-15 (Bmp15), Tgfb1, and growth and differentiation factor 9 (Gdf9).…”

Section: Introductionmentioning

confidence: 99%

Comparison of fecundity and offspring immunity in zebrafish fed Lactobacillus rhamnosus CICC 6141 and Lactobacillus casei BL23

Qin

Xu²,

Yang³

et al. 2014

Reproduction

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To increase the knowledge of probiotic effects on zebrafish (Danio rerio), we compare the effects of two probiotic strains, Lactobacillus rhamnosus CICC 6141 (a highly adhesive strain) and Lactobacillus casei BL23 (a weakly adhesive strain), on zebrafish reproduction and their offsprings' innate level of immunity to water-borne pathogens. During probiotics treatments from 7 to 28 days, both the Lactobacillus strains, and especially L. casei BL23, significantly increased fecundity in zebrafish: higher rates of egg ovulation, fertilization, and hatching were observed. Increased densities of both small and large vitellogenic follicles, seen in specimens fed either Lactobacillus strain, demonstrated accelerated oocyte maturation. Feeding either strain of Lactobacillus upregulated gene expression of leptin, kiss2, gnrh3, fsh, lh, lhcgr, and paqr8, which were regarded to enhance fecundity and encourage oocyte maturation. Concomitantly, the gene expression of bmp15 and tgfb1 was inhibited, which code for local factors that prevent oocyte maturation. The beneficial effects of the Lactobacillus strains on fecundity diminished after feeding of the probiotics was discontinued, even for the highly adhesive gut Lactobacillus strain. Administering L. rhamnosus CICC 6141 for 28 days was found to affect the innate immunity of offspring derived from their parents, as evinced by a lower level of alkaline phosphatase activity in early larval stages. This study highlights the effects of probiotics both upon the reproductive process and upon the offsprings' immunity during early developmental stages.

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Section: Introductionmentioning

confidence: 99%

Comparison of fecundity and offspring immunity in zebrafish fed Lactobacillus rhamnosus CICC 6141 and Lactobacillus casei BL23

Qin

Xu²,

Yang³

et al. 2014

Reproduction

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“…All juvenile zebrafish develop an ovary-like structure (juvenile ovary), which will either develop into a definite ovary in females or transform into a testis in males around 45 days post-fertilization (dpf; Chen & Ge 2013). It takes w3 months to reach sexual maturity (Clelland & Peng 2009). Puberty is defined as the period that marks the transition from sexual immaturity to maturity.…”

Section: Introductionmentioning

confidence: 99%

Zebrafish pituitary gene expression before and after sexual maturation

He¹,

Dai²,

Chen³

et al. 2014

Journal of Endocrinology

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Sexual maturation and somatic growth cessation are associated with adolescent development, which is precisely controlled by interconnected neuroendocrine regulatory pathways in the endogenous endocrine system. The pituitary gland is one of the key regulators of the endocrine system. By analyzing the RNA sequencing (RNA-seq) transcriptome before and after sexual maturation, in this study, we characterized the global gene expression patterns in zebrafish pituitaries at 45 and 90 days post-fertilization (dpf). A total of 15 043 annotated genes were expressed in the pituitary tissue, 3072 of which were differentially expressed with a greater than or equal to twofold change between pituitaries at 45 and 90 dpf. In the pituitary transcriptome, the most abundant transcript was gh. The expression levels of gh remained high even after sexual maturation at 90 dpf. Among the eight major pituitary hormone genes, lhb was the only gene that exhibited a significant change in its expression levels between 45 and 90 dpf. Significant changes in the pituitary transcripts included genes involved in the regulation of immune responses, bone metabolism, and hormone secretion processes during the juvenile-sexual maturity transition. Real-time quantitative PCR analysis was carried out to verify the RNA-seq transcriptome results and demonstrated that the expression patterns of the eight major pituitary hormone genes did not exhibit a significant gender difference at 90 dpf. For the first time, we report the quantitative global gene expression patterns at the juvenile and sexual maturity stages. These expression patterns may account for the dynamic neuroendocrine regulation observed in body metabolism.

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“…Zebrafish follicles consist of a large oocyte encased by a zona radiata with a surrounding follicular layer composed of an outer layer of theca cells separated by a basement membrane from an inner layer of granulosa cells (Clelland & Peng, 2009). In adult zebrafish, follicular development primarily occurs in two stages, growth and maturation, which are predominantly controlled through the action of hormones.…”

Section: Zebrafish (Danio Rerio)mentioning

confidence: 99%

“…Steroid hormones have long been recognized as the key regulators of ovarian development (Clelland & Peng, 2009). Nagahama et al (1994Nagahama et al ( , 1995 proposed a twocell model for follicular recruitment which begins with FSH binding to a G-protein coupled receptor in the theca cells to stimulate the synthesis of estradiol 17β (E 2 ).…”

Section: Zebrafish (Danio Rerio)mentioning

confidence: 99%

“…The production of E 2 begins with a sequence of enzymatic events that take place in the theca cells, transforming cholesterol into testosterone. Testosterone is then released from the theca cells, passively diffuses to the granulosa cells and is converted into E 2 through the action of aromatase (Arom-A) (Clelland & Peng, 2009). This is the beginning of the major growth phase in follicles, which occurs in vitellogenic follicles and accordingly the expression of Arom-A has been found to be highest in this stage (GotoKazeto, Kight, Zohar, Place, & Trant, 2004).…”

Section: Zebrafish (Danio Rerio)mentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of spawning in zebrafish (Danio rerio): Adverse outcome pathways of quinacrine and ethinylestradiol

Cosme

Lister

Kraak

2015

General and Comparative Endocrinology

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INHIBITION OF SPAWNING IN ZEBRAFISH (Danio rerio): ADVERSE OUTCOME PATHWAYS OF QUINACRINE AND ETHINYLESTRADIOL Madelyne CosmeAdvisor: University of Guelph, 2014Professor. Glen Van Der KraakThis study examined the effects of estrogen receptor agonist, ethinylestradiol, and the phospholipase A 2 inhibitor, quinacrine, on the pathways controlling follicular recruitment, steroidogenesis, oocyte maturation and ovulation and spawning success in the adult zebrafish. Ethinylestradiol and quinacrine both inhibit spawning but did so through different adverse outcome pathways. Ethinylestradiol affected follicular recruitment (reduced ovarian size and reduction in the proportion of cortical alveolus, vitellogenic and mature follicle stages), steroidogenesis (reduced expression of aromatase) maturation (reduced luteinizing hormone receptor expression) and ovulation (reduced expression of cytosolic phospholipase A2 and the nuclear progesterone receptor). Quinacrine targeted ovulation via a reduction of the steroid 17α, 20β dihydroxy-4-prenen-3-one and expression of the prostaglandin metabolizing enzyme cyclooxygenase 2. Collectively, these studies suggest that a targeted assessment of reproductive endpoints can be used effectively to identify the adverse outcome pathways by which toxicants can impact reproductive fitness.iii ACKNOWLEDGEMENTS

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Endocrine/paracrine control of zebrafish ovarian development

Cited by 231 publications

References 124 publications

Comparison of fecundity and offspring immunity in zebrafish fed Lactobacillus rhamnosus CICC 6141 and Lactobacillus casei BL23

Comparison of fecundity and offspring immunity in zebrafish fed Lactobacillus rhamnosus CICC 6141 and Lactobacillus casei BL23

Zebrafish pituitary gene expression before and after sexual maturation

Inhibition of spawning in zebrafish (Danio rerio): Adverse outcome pathways of quinacrine and ethinylestradiol

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