Endocrine Management of Selected Cases of Allergy Based on Enzymatic Mechanism of Sensitization

Godlowski, Z. Z.

doi:10.1001/archotol.1960.03770030155029

Cited by 10 publications

(2 citation statements)

References 85 publications

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“…Historically, a number of investigators initially suggested that the metabolic changes occuring in hypothyroidism were capable of producing the symptoms seen in MD. 2,5,[14][15][16][17] Others later refuted this explanation, however. [18][19][20][21] Another possibility would be that autoimmune thyroid disease may directly cause some cases of MD; yet, this also seems unlikely as a clear association between MD and clinically significant autoimmune thyroid disease (ie, disease requiring treatment) has been reported in only a handful of patients.…”

Section: Commentmentioning

confidence: 99%

Prevalence of Thyroid Dysfunction in Patients With Ménière's Disease

Brenner¹,

Hoistad²,

Hain³

2004

Arch Otolaryngol Head Neck Surg

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To estimate the prevalence of hypothyroidism in a population of patients with Ménière's disease (MD).Design: Retrospective case-control study comparing the use of thyroid hormone supplements between patients with MD and controls.Setting: Outpatient neurology clinic specializing in the management of patients experiencing dizziness.Patients: Fifty patients who met the 1995 American Academy of Otolaryngology criteria for MD and 50 controls matched for age and sex also experiencing dizziness. Results:The 50 patients who met the criteria for MD were identified from a database of more than 2000 patients with dizziness seen over a 5-year period. Of these, 16 (32%) were taking thyroid hormone supplements in contrast to 2 (4%) of the 50 matched controls (PϽ.001). The median age of the patients with MD was 60 years, and 5 (19%) of the 26 patients younger than 60 years were taking thyroid hormone supplements, compared with 11 (46%) of 24 patients 60 years or older (PϽ.05). There were no statistically significant differences in the severity of hearing loss, pattern of hearing loss, or prevalence of bilateral hearing loss between patients with MD who were taking thyroid hormone supplements and patients with MD who were not. Conclusion:Ménière's disease is associated with corrected hypothyroidism.

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Section: Commentmentioning

confidence: 99%

Prevalence of Thyroid Dysfunction in Patients With Ménière's Disease

Brenner¹,

Hoistad²,

Hain³

2004

Arch Otolaryngol Head Neck Surg

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“…Case reports suggesting control of hearing impairment with thyroid hormone supplementation date back to the 1950s [22]. Godlowski et al [23] first proposed hypometabolism as a potential factor in MD. Spencer et al [24] concluded that a significantly high incidence of abnormal lipid metabolism occurs in MD.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Dysfunction in Ménière’s Disease: A Comprehensive Review

Hwang¹,

Saadi²,

Patel³

et al. 2021

ORL

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Introduction: The precise etiology of Ménière’s disease (MD) remains unknown; however, given the association of MD with serum antibodies and human leukocyte antigen (HLA) complex, several studies have proposed a relationship between MD and thyroid disorders. Similarly, multiple hypotheses exist regarding the metabolic disturbances of fluctuating thyroid hormone as a potential contributing agent in the development of MD. Methods: A total of 171 abstracts were identified and screened by 2 independent reviewers. Based on inclusion and exclusion criteria, 8 studies were selected for final analysis. Due to heterogeneity of clinical data, meta-analysis was not feasible. Results: The prevalence of autoimmune thyroid disease and hypothyroidism in MD varied significantly from 1 to 38%. Notable bias was introduced given the lack of standardization of diagnostic criteria across studies. Articles that described autoimmune thyroid-specific antibodies and HLA types also presented inconclusive results. Multiple studies noted a potential etiologic role of hypothyroidism in MD, which was often confounded by thyroxine supplementation. Conclusions: Despite a potential correlation in the medical literature between thyroid disorders and MD, there is currently no definitive causal relationship. Although most of the present medical literature focuses on autoimmunity, dysregulated thyroid hormone levels may also be implicated in the association of MD with thyroid disorders.

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Progress in Allergy 1959-1960

Anderson¹

1961

Archives of Otolaryngology - Head and Neck Surgery

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Endocrine Management of Selected Cases of Allergy Based on Enzymatic Mechanism of Sensitization

Cited by 10 publications

References 85 publications

Prevalence of Thyroid Dysfunction in Patients With Ménière's Disease

Prevalence of Thyroid Dysfunction in Patients With Ménière's Disease

Thyroid Dysfunction in Ménière’s Disease: A Comprehensive Review

Progress in Allergy 1959-1960

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