Endocrine Interrelationnship and Spontaneous Tumors of the Adrenal Cortex in NH Mice

Abstract

645produce a similar toxicity in the rat.A reduction in the level of dietary fat to 0.5% decreased the toxicity of DDT in both species; when the diet contained 15% of fat, the symptoms of toxicity were aggravated. Several different types of fat were essentially equal in aggravating the toxicity.On a low protein diet (10%) the toxicity of DDT was increased somewhat; whereas on a high protein diet (30%) the effects were variable.

Pituitaries of Spayed Mice of Different Strains: Cytology and Gonadotrophin Content

“…Barnes (1962Barnes ( , 1963 has described the changes in the pituitaries of ovariectomized mice as seen by light and electron microscopy. Sex steroid-secreting adrenocortical neoplasms have been induced in several strains of mice after gonadectomy (Gardner, 1941;Woolley, 1942;Frantz, Kirschbaum & Casas, 1947 ;Frantz & Kirschbaum, 1949). Either nodular hyperplasia, adenoma or carcinoma may be found according to the strain of mouse.…”

Adrenalectomy and Steroid Treatment in Obese (ob/ob) and Diabetic (db/db) Mice

“…Subcutaneous implants of either corticosterone or deoxycorticosterone induce adiposity in LAFI mice (Kendall 1945). Adrenalectomy, on the other hand, reduced body fat in experimental animals (Cohn, Shargo and Joseph 1955;Schiffer and Wertheimer 1947) and will prevent or reverse the obesity in mice carrying ACTH producing tumors (Hausberger and Hausberger 1959) and the obesity in the NH mouse (Frantz, Kirschbaum and Casas 1947). In rats and mice with hypothalamic obesity, adrenalectomy has been reported to prevent the development obesity, providing adrenalectomy is complete (Bruce, King, Phelps and Veitia 1982;Debons, Siclari, Das and Fuhr 1982).…”