Endocrine Inhibition as Related to Carcinoma of the Prostate

Effect of Cortisone on Reactivated Metastatic Carcinoma of Prostate

“…Serum acid phosphatase (SAP). Valk and Owens (17) reported a fall in the serum acid phosphatase level in 8 of 12 cases during cortisone therapy. Miller and Hinman (15) noted that 3 of the 4 patients with initially elevated serum acid phosphatase levels showed a decrease in SAP under cortisone.…”

“…Local lesion. Valk and Owens (17) found no change during cortisone therapy in the local lesion of 12 patients with relapsing carcinoma of the prostate. On the other hand, 6 of 10 cases reported by Miller and Hinman showed moderate to marked improvement on rectal palpation.…”

“…Hayward (16), Valk and Owens (17), and Miller and Hinman (15) have noted relief of pain with improved appetite and weight gain in some patients with relapsing metastatic prostatic carcinoma when treated with cortisone, 25 to 100 mg. daily in divided doses. Two of our 7 patients realized this benefit, although in 1 it was for only two months in spite of continued cortisone therapy.…”

Die hormonale Behandlung des Prostata-Carcinoms

“…Die v o r h errsc h e n d e M einung is t, d a ß es sich hierbei in allen F ällen um M eta sta se n des p rim ä re n P ro sta ta c a rc in o m s h an d elt u n d n ich t um p rim äre B ru stk re b se [4]. 6 0 -7 0 % aller P a tie n te n m it in o p erab lem P ro sla ta c a rc in o m e rfa h ren d u rc h a n tia n d ro g è n e M aßn ah m en eine d ra m a tisc h e klinische B esserung [46]. W en n a u c h selten im R ö n tg en b ild eine V erm in d eru n g d e r K n o c h e n m e la sta se n nachgew iesen w erden k a n n , so s te h t doch d as T u m o rw a c h stu m w äh ren d M onaten still un d die su b je k tiv e n S y m p to m e v ersch w in d en m eistens ganz.…”

“…In ca. 6 0 % der P a tie n te n k a n n eine R em ission erzielt w erden, die jed o ch von k ü rzerer D a u e r ist als die vorg än g ig d u rc h K a s tra tio n u n d /o d e r A nw endung vo n Ö strogenen erre ic h te [46,35].…”