Endocrine host responses during early and late phases of tumor development

Besedovsky, Hugo O.; Normann, Sigurd J.; Schardt, M.; Rey, Adriana del

doi:10.1002/(sici)1097-0215(20000515)86:4<457::aid-ijc2>3.0.co;2-0

Cited by 5 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, pre-exposure to CUS followed by DMBA or DMBA-TPA infusion resulted in significantly increased oxidative stress and enhanced the incidence of skin papillomas relative to their non-stressed counterparts, with comparable effects being observed in the pre-stress DMBA-and DMBA-TPAtreated groups, suggesting that the role of stress in enhancing the carcinogenic potential of DMBA is comparable to TPA. Further, a concordance exists between endocrine changes induced by large tumor burdens, consisting of increased corticosterone and growth hormone (Besedovsky et al 2000). Thus, the present study further confirms that stress accelerates the onset of tumor formation produced in response to DMBA and significantly influences the type and location of tumors as reported earlier (Flint et al 2011).…”

Section: Discussionsupporting

confidence: 89%

Chronic unpredictable stress (CUS) enhances the carcinogenic potential of 7,12-dimethylbenz(a)anthracene (DMBA) and accelerates the onset of tumor development in Swiss albino mice

Suhail

Bilal

Hasan

et al. 2015

Cell Stress and Chaperones

View full text Add to dashboard Cite

Social stressors evolving from individual and population interactions produce stress reactions in many organisms (including humans), influencing homeostasis, altering the activity of the immunological system, and thus leading to various pathological states including cancer and their progression. The present study sought to validate the effectiveness of chronic unpredictable stress (CUS) in cancer promotion and to assess oxidative stress outcomes in terms of various in vivo biochemical parameters, oxidative stress markers, DNA damage, and the development of skin tumors in Swiss albino mice. Animals were randomized into different groups b a s e d o n t h e i r e x p o s u r e t o C U S a l o n e , 7 , 1 2 -dimethylbenz(a)anthracene (DMBA) alone (topical), and DMBA-12-O-tetradecanoylphorbol-13-acetate (TPA) (topical) and exposure to CUS prior to DMBA or DMBA-TPA treatments and sacrificed after 16 weeks of treatment. Prior exposure to CUS significantly increased the pro-oxidant effect of carcinogen, depicted by compromised levels of antioxidants in the circulation and skin, accompanied by enhanced lipid peroxidation, plasma corticosterone, and marker enzymes as compared to DMBA-alone or DMBA-TPA treatments. DNA damage results corroborated the above biochemical outcomes. Also, the development of skin tumors (in terms of their incidence, tumor yield, and tumor burden) in mice in the presence and absence of stress further strongly supported our above biochemical measurements. CUS may work as a promoter of carcinogenesis by enhancing the pro-oxidant potential of carcinogens. Further studies may be aimed at the development of interventions for disease prevention by identifying the relations between psychological factors and DNA damage.

show abstract

Section: Discussionsupporting

confidence: 89%

Chronic unpredictable stress (CUS) enhances the carcinogenic potential of 7,12-dimethylbenz(a)anthracene (DMBA) and accelerates the onset of tumor development in Swiss albino mice

Suhail

Bilal

Hasan

et al. 2015

Cell Stress and Chaperones

View full text Add to dashboard Cite

show abstract

“…This not only applies to infectious processes but also for cancer cachexia. A striking manifestation characterized by a depletion of skeletal muscle and white adipose tissue mass, affecting around half of all patients with cancer (Bing and Trayhurn, 2008), in which the chronic inflammatory state, mostly due to the host's reaction to the presence of the tumor seems to be involved (Argiles et al, 2003(Argiles et al, , 2009Besedovsky et al, 1985Besedovsky et al, , 2000Bing and Trayhurn, 2008;Deans and Wigmore, 2005;Delano and Moldawer, 2006).…”

Section: The Relation Of Systemic Immuno-endocrine Alterations With T...mentioning

confidence: 99%