Endocrine Effects of Pimozide, a Specific Dopaminergic Blocker

Collu, R.; Jéquier, J.-C.; Leboeuf, G; Letarte, Jacques; Ducharme, J R

doi:10.1210/jcem-41-5-981

Cited by 62 publications

(23 citation statements)

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“…It should be noted that the elevation of serum TSH levels fol lowing blockade of DA receptors is quite small and in nor mal subjects usually does not exceed 1.0 uU/ml. This to gether with a relatively large interindividual variability may perhaps explain several negative results [43,50,91,124], Hard to fit into this general framework is the report of Collu et al [17] that pimozide, another DA receptor blocker caused a marked decrease of TSH levels in euthyroid sub jects. Colin's results were, however, not corroborated by a recent study [19] showing that the classical dopamine recep tor blockers pimozide or haloperidol are as effective as the substituted benzamides metoclopramide or sulpiride in stimulating TSH secretion in humans.…”

Section: Dopaminementioning

confidence: 99%

Neurotransmitter Control of Thyrotropin Secretion

Krulich

1982

Neuroendocrinology

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The central dopaminergic system seems to have an inhibitory influence on the secretion of thyrotropin (TSH) both in humans and rats. This is documented by observations that in humans, especially in subjects with primary hypothy-roidism, the dopamine precursor l-Dopa, dopamine receptor agonist bromocryptine, and dopamine itself decrease plasma levels of TSH and in some instances inhibit TSH secretory response to thyrotropin-releasing hormone (TRH). Conversely blockade of dopamine receptors leads to an elevation of circulating TSH. It is probable the dopaminergic drugs act on the pituitary thyrotrops rather than on the release of hypothalamic TRH. Analogous results were obtained in rats. In contrast, the noradrenergic system, studied mainly in rats, has a stimulatory influence on the secretion of TSH. This view is mainly supported by findings that acute interruption of noradrenergic neurotransmission causes a decrease of serum TSH levels and blocks the cold-induced stimulation of TSH secretion. The role of the central serotonergic system remains undecided because some experimental findings indicate that it has an inhibitory influence but others indicate an opposite function. The remaining transmitter systems have not been studied extensively enough to allow definite conclusions about their roles in the regulation of TSH secretion.

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Section: Dopaminementioning

confidence: 99%

Neurotransmitter Control of Thyrotropin Secretion

Krulich

1982

Neuroendocrinology

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“…Different effects on TSH secretion of dopamine blocking drugs have been reported and seem to depend on whether treatment is given acutely or chronically. Thus the acute administration of chlorpromazine to normal subjects induced significant elevations in plasma TSH levels (Paracchi et al, 1975), while chronic (4 days) treatment with pimozide resulted in decreased plasma TSH levels in normal subjects (Collu et al, 1975).…”

Section: Thymid Stimulating Hormone (Tsh)mentioning

confidence: 99%

The Role of Serotonin and Dopamine in Hypothalamic‐pituitary Function

Smythe¹

1977

Clinical Endocrinology

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“…In contrast, the role of dopamine (DA) in the control of LH release is less clear. While DA and DA agonists have been reported to inhibit LH release in some studies [6][7][8], stimulatory effects o f DA have also been reported in others [4,5,9,10].Relative to the vast number of studies in which LH levels were used as an indicator of activity in the hypothalamic-pitu itary axis, there are few reports examining the effects of cate cholaminergic agonists and antagonists on LHRH release di rectly. For instance, NE was reported to stimulate LHRH re lease from rat median eminence in vitro, an effect that was blocked by the a-adrenergic antagonist phentolamine [11].…”

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confidence: 99%

The Alpha-1-Adrenergic Neuronal System Is Involved in the Pulsatile Release of Luteinizing Hormone-Releasing Hormone in the Ovariectomized Female Rhesus Monkey

Gearing¹,

Terasawa²

1991

Neuroendocrinology

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It has been postulated that catecholamines are integral to the control of LHRH release. In the present study, the roles of adrenergic and dopaminergic receptors in the control of pulsatile LHRH release are examined. The effects of prazosin (an αi-antagonist), rauwolscine (an α₂-antagonist), propranolol (a β-antagonist), haloperidol (a dopamine antagonist), SCH23390 (a D₁ antagonist), and LY163502 (a D₂ agonist), on in vivo LHRH release in the stalk-median eminence were tested in ovariectomized female rhesus monkeys using push-pull perfusion. Prazosin caused a significant suppression of the LHRH release. This was primarily due to a significant suppression of LHRH pulse amplitude, but not pulse frequency, i.e. the interpulse interval was not affected by the administration of prazosin. In contrast to prazosin, none of the other adrenergic or dopaminergic drugs had significant effects on LHRH release. We conclude from these results that (1) the stimulatory effects of norepinephrine (NE) and/or epinephrine on pulsatile LHRH release are mediated by αi -adrenergic receptors but not α₂or β-adrenergic receptors, and (2) dopaminergic receptors do not appear to be involved in pulsatile LHRH release in ovariectomized rhesus monkeys.

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Endocrine Effects of Pimozide, a Specific Dopaminergic Blocker

Cited by 62 publications

References 0 publications

Neurotransmitter Control of Thyrotropin Secretion

Neurotransmitter Control of Thyrotropin Secretion

The Role of Serotonin and Dopamine in Hypothalamic‐pituitary Function

The Alpha-1-Adrenergic Neuronal System Is Involved in the Pulsatile Release of Luteinizing Hormone-Releasing Hormone in the Ovariectomized Female Rhesus Monkey

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