Endocrine effects of organophosphate antidotal therapy

Satar, Salim; Sebe, Ahmet; Topal, Metin; Karcıoğlu, Özgür

doi:10.1007/bf02850034

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…As regards serum cortisol level, this study revealed that median cortisol level at admission was 47.3μg/dl. This is partially similar to Satar, (2004) who reported median cortisol level at admission was 41.8μg/dl. Other studies as Güven et al, (1999) andDutta et al, (2015) reported that the mean cortisol level at admission was 25.5± 14 and 34.3 μg/dl respectively.…”

Section: Resultssupporting

confidence: 90%

The role of cortisol and thyroid stimulating hormone in prognosis of acute anticholinesterase pesticides poisoned patients admitted to Tanta Poison Control Center

Masoud¹,

Heshmat²,

Soliman³

et al. 2022

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Introduction: Anticholinesterase poisoning is a major global health problem with thousands of deaths each year. Determination of prognosis is a major concern for clinical toxicologists. Previous studies reported that cortisol and thyroid stimulating hormone (TSH) may have prognostic role in patients poisoned by organophosphates. Aim of the work: Evaluation of prognostic role of cortisol and TSH in acute anticholinesterase pesticides poisoned patients admitted to Tanta Poison Control Center. Methodology: This prospective study included 29 patients of moderate to severe acute anticholinesterase poisoning according to poisoning severity score (PSS) between August 2019 and July 2020. TSH and serial cortisol were assessed by ELISA techniques. Results: TSH has no prognostic role, but cortisol has predictive role in mortality, need for ICU admission and intubation. Conclusion: Measuring cortisol at admission, after six and twelve hours from admission could predict need for ICU admission, intubation and mechanical ventilator, while measuring it at admission can be predictor for mortality.

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Section: Resultssupporting

confidence: 90%

The role of cortisol and thyroid stimulating hormone in prognosis of acute anticholinesterase pesticides poisoned patients admitted to Tanta Poison Control Center

Masoud¹,

Heshmat²,

Soliman³

et al. 2022

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…LH is secreted by the pituitary gland then induces Leydig cells to secrete testosterone. Many OPs were tested for their effect on plasma levels of testosterone (Blanco-Muñoz et al 2010;Satar et al 2004). In our experiment, introducing malathion for 4 weeks was associated with a reduction in plasma levels of testosterone.…”

Section: Discussionmentioning

confidence: 97%

Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin

Ali

Ibrahim

2018

Egypt J Forensic Sci

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Background: The organophosphorus (OP) pesticide malathion is a highly neurotoxic compound, leading to cholinergic syndrome. Malathion produces reproductive toxicity. Objectives: To investigate the protective effects of curcumin on the testicular toxicity induced in male mice orally administrated with malathion.Materials and methods: Forty-eight mature male mice were used. The mice were divided into four groups, 12 mice each, and treated for 4 weeks as follows: the control (G1), curcumin-treated group (G2), malathiontreated group (G3), and the curcumin plus malathion-treated group (G4). At the end of the experiment, the mice were sacrificed and dissected, and tissue samples were obtained and antioxidant parameters were examined. Tissue samples were also histopathologicaly and immunohistochemically assessed. Samples of blood were collected for assessing the levels of serum hormones, namely follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and acetylcholinesterase activity (AChE). Results: Malathion exposure caused a decrease in serum testosterone and LH levels and antioxidant enzymes (SOD and CAT) and elevation of oxidative stress marker (MDA). Histological changes were as well observed in the form of maturation abnormalities, intratubular necrosis, and inflammatory infiltrate in malathion-treated mice. Co-administration of curcumin with malathion reduced lipid peroxidation (LPO) activity and improved spermatogenesis and increased catalase (CAT), superoxide dismutase (SOD), and testosterone levels. Conclusion:The current study showed that curcumin could ameliorate the elevated concentration of lipid peroxidation products, increase the levels of antioxidative markers, and improve the pathological changes in the testis induced by malathion administration. The capacity of curcumin to work as antioxidant supposedly relates to its structure.

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“…Chronic exposure to organophosphate insecticides has been associated with neuropsychological conditions and has more recently been shown to have specific endocrine effects [5][6][7]. We are reporting the results of the effect of prolonged low-dose exposure to chlorpyrifos, an organophosphate insecticide, in young rats that gained weight.…”

Section: Introductionmentioning

confidence: 95%

Weight gain associated with chronic exposure to chlorpyrifos in rats

Meggs

Brewer

2007

J. Med. Toxicol.

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Objective: This work exposed rats to low levels of the organophosphate insecticide chlorpyrifos and monitored for toxic effects, including weight gain.Methods: Rats received either a subcutaneous injection of chlorpyrifos, 5 mg/kg/day, or an equal volume of vehicle daily for 4 months. Subjects were observed for 30 minutes after injection for signs of acute toxicity. Body weights were recorded at baseline, 2 months, 3 months, and 4 months. At the end of the experiment, the weights of hearts, medial lobe of the livers, peri-nephric fat pads, and gastrocnemius muscles were recorded. Effects of chlorpyrifos on adipocyte differentiation in culture were studied. Results were compared using RMANOVA.Results: No signs of acute cholinergic toxicity were observed after injections in any subject. Rats in the 5 mg/kg group were significantly heavier than those in the control group by 2 months (335.7 Ϯ 16.7 g vs. 318.6 Ϯ 15.8 g; p ϭ 0.034). This difference increased at 3 months (350.1 Ϯ 16.4 g vs. 322.3 Ϯ 21.3 g p ϭ 0.006) and 4 months (374.4 Ϯ 22.2 g vs. 340.2 Ϯ 25.2 g p ϭ 0.006). At 4 months, the weights of the perinephric fat pads were significantly increased in the chlorpyrifos group relative to controls (2.867 ϩ 0.516 vs. 1.130 ϩ 0.171, p ϭ 0.0039). The two groups showed no weight differences between hearts, livers, and gastrocnemius muscles. Chlorpyrifos did not affect adipocyte differentiation in tissue culture.Conclusions: Chronic exposure to chlorpyrifos at 5 mg/kg/day caused an increase in rat body weight when compared to controls. This increase was in adipose tissue. Chlorpyrifos did not induce differentiation of adipocytes in culture.

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Endocrine effects of organophosphate antidotal therapy

Cited by 8 publications

References 23 publications

The role of cortisol and thyroid stimulating hormone in prognosis of acute anticholinesterase pesticides poisoned patients admitted to Tanta Poison Control Center

The role of cortisol and thyroid stimulating hormone in prognosis of acute anticholinesterase pesticides poisoned patients admitted to Tanta Poison Control Center

Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin

Weight gain associated with chronic exposure to chlorpyrifos in rats

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