Endocrine Disruptors of the Bisphenol and Paraben Families and Bone Metabolism

Vítků, Jana; Kolátorová, Lucie; Franeková, Lenka; Blahoś, J; Šimková, M; Dušková, Michaela; Škodova, Tereza; Stárka, L

doi:10.33549/physiolres.934005

Cited by 40 publications

(16 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A similar finding was reported in a very recent study in women. 64 The authors suggested that increased calcium may be the result of higher intestinal absorption and/or reabsorption in the kidneys. Nevertheless, studies in laboratory rodents did not confirm this hypothesis and this association is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings

Kovaříková

Maršálek

Habánová

et al. 2020

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Objectives Bisphenol A (BPA) has been mentioned as a possible factor contributing to feline hyperthyroidism. Nevertheless, there are no previous studies reporting on the concentration of BPA in feline serum and its association with thyroid function. The objectives of this study were to measure serum BPA concentration in cats aged ⩾7 years, considered as healthy by their owners, and to compare the results with clinicopathological findings. Methods Sixty-nine cats aged ⩾7 years considered as healthy by their owners were enrolled in the study. The concentration of BPA in feline serum was measured using liquid chromatography–tandem mass spectrometry. In all cats, signalment, living environment, diet history, and the results of haematological and biochemical analysis, including thyroxine levels, were available. Results The mean serum BPA concentration in feline serum was 1.06 ± 0.908 ng/ml. Significant correlation was found between BPA concentration and haemoglobin ( r = 0.3397; P = 0.0043), haematocrit ( r = 0.3245; P = 0.0065) and the number of red blood cells ( r = 0.2916; P = 0.0151), concentration of total protein ( r = 0.2383; P = 0.0486), concentration of calcium ( r = 0.3915; P = 0.0009) and level of bilirubin ( r = 0.3848; P = 0.0011). No other significant correlations were found. Significant differences ( P <0.01) were found between mature (1.28 ± 0.994 ng/ml) and geriatric cats (0.420 ± 0.240 ng/ml), between strictly indoor cats (1.27 ± 0.992 ng/ml) and cats with outdoor access (0.660 ± 0.529 ng/ml), and between cats fed canned food (1.23 ± 0.935 ng/ml) and cats fed non-canned food (0.774 ± 0.795 ng/ml). Conclusions and relevance Measurable serum BPA levels were found in all examined samples. The age of the cats was revealed as a significant factor affecting BPA concentration and mature cats had the highest levels. A significantly higher concentration of BPA was found in cats living strictly indoors and in cats fed canned food. No association was found between BPA and thyroid function. Further studies are needed that focus on hyperthyroid cats for better evaluation of this relationship.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings

Kovaříková

Maršálek

Habánová

et al. 2020

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…Thus far, studies on the associations of bisphenol and phthalates with skeletal health in humans are scarce. Small studies among post-menopausal women suggested that bisphenol A (BPA) and phthalate exposure may unfavorably affect bone homeostasis, which might lead to osteoporosis ( Vitku et al, 2018 ; Min and Min, 2014 ). Fetal life seems to be a critical period for EDCs exposure because organs and systems are changing more rapidly during this period ( Golub et al, 2004 ; Anway et al, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Fetal exposure to bisphenols and phthalates and childhood bone mass: a population-based prospective cohort study.

Janssens

Trasande

Asimakopoulos

et al. 2020

Environmental Research

View full text Add to dashboard Cite

Background: Exposure to bisphenols and phthalates might influence bone health. We hypothesized that exposure to bisphenols and phthalates during fetal life has persistent effects on bone development. Objectives: To analyze the associations of fetal exposure to bisphenols and phthalates with bone health in school-aged children. Methods: Among 1,362 mother-child pairs participating in a population-based cohort study, we measured maternal urinary concentrations of bisphenols and phthalates at first, second and third trimester with high performance liquid chromatography electrospray ionization-tandem mass spectrometry. Total body bone mineral density (BMD) and bone area (BA) were measured using dual-energy X-ray absorptiometry (DXA) at 6 and 10 years, and were both used to calculate bone mineral content (BMC) and area-adjusted BMC (aBMC, a measure of volumetric BMD). Results: Maternal bisphenol concentrations were not associated with childhood bone measures at 6 years. After adjustment for covariates and multiple testing correction, an interquartile range increase in maternal first trimester bisphenol S (BPS) concentrations was associated with lower BMD and aBMC at 10 years (−6.08 (95% confidence interval (CI), −9.97 to −2.19) mg/cm 2 and −0.12 (95% CI, −0.20 to −0.04) g). Maternal third trimester low molecular weight (LMW) phthalate concentrations were associated with higher aBMC at 6 years whereas, maternal third trimester di-n-octylphthalate (DNOP) concentrations were associated with lower aBMC at 10 years. However, these associations did not remain statistically significant after multiple testing correction. Discussion: Maternal first trimester BPS concentrations are associated with lower BMD and aBMC in school-aged children. These findings should be considered as hypothesis generating and need further replication and exploration of potential underlying mechanisms.

show abstract

“…In another study of 256 premenopausal women, there was no correlation between BPA exposure and BMD after adjustment for body mass index [56]. In another study of 14 women with osteoporosis and 10 age-matched healthy controls, there were no differences in urinary BPA concentrations between the two groups [57]. In a study involving 754 school-aged children, there was no correlation between urinary BPA levels and height in girls;…”

Section: Human Exposure Studiesmentioning

confidence: 94%

“…In humans, only four studies have looked at possible relationships between BPA exposure and skeletal health. In adult women, there have been no correlations between serum or urine BPA levels and BMD [55][56][57]. In a study in school-aged children, there was no correlation between urinary BPA levels and height in girls however, there was a significant negative correlation between urinary BPA levels and height in boys, which remained even when adjusted for pubertal status and at follow up 19 months later [58].…”

Section: Bpa and Bonementioning

confidence: 99%

See 1 more Smart Citation

Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha]

Dirkes¹

View full text Add to dashboard Cite

Estrogen is one of the most influential hormones on bone growth and maintenance throughout the life cycle in both men and women, but there are still unknown roles of estrogen and the estrogen receptors in males. In addition, exposure to xenoestrogens, or environmental compounds that have anti-estrogenic qualities, is increasing in industrial countries, but the impact of these compounds on skeletal health in males and females remains unknown. In this dissertation, we used animal models to explore a, the importance of estrogen receptor-[alpha] (ER[alpha]) in male mice at different points in the life cycle and b, the long-term impact of gestational exposure to xenoestrogens, specifically bisphenol-A (BPA) and bisphenol-S (BPS), on male and female offspring. We found that both young and aged male ER[alpha] knockout (ERKO) animals had impaired measures of cortical geometry, but improved measures of trabecular microarchitecture, implying differential roles for ER[alpha] in different bone compartments. We also found that ERKO could lead to increased expression of sclerostin, a bone growth inhibitor, in aged, male mice. In younger, male ERKO mice we found that ERa is not required for an osteogenic response to exercise, which is in direct contrast with females. Finally, we found that gestational and lactational exposure to BPA, but not BPS, had significant negative impacts on the skeleton of adult male, but not female, mice. Male offspring exposed to BPA had significantly lower measures of both cortical geometry and trabecular microarchitecture, indicating long-term effects of interrupted estrogen signaling during uterine and early childhood on skeletal development. These findings further our understandings of the importance of estrogen on skeletal health across the lifespan and could have significant public health impacts if they are translatable to humans.

show abstract

Endocrine Disruptors of the Bisphenol and Paraben Families and Bone Metabolism

Cited by 40 publications

References 52 publications

Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings

Serum concentration of bisphenol A in elderly cats and its association with clinicopathological findings

Fetal exposure to bisphenols and phthalates and childhood bone mass: a population-based prospective cohort study.

Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha]

Contact Info

Product

Resources

About