Endocrine disruptors of sex hormone activities

Varticovski, Lyuba; Stavreva, Diana A.; McGowan, Andrew; Raziuddin, Razi; Hager, Gordon L.

doi:10.1016/j.mce.2021.111415

Cited by 31 publications

(16 citation statements)

References 208 publications

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“…Los DE corresponden a una gran familia de compuestos que son perjudiciales para la salud humana, ya que estos influyen a nivel del sistema endocrino y alteran el desarrollo normal tanto en humanos como en animales, además, pueden estar presentes en el ambiente por medio del aire, suelo, fluidos corporales, agua, alimentos, leche materna, cosméticos, utensilios del hogar, aparatos electrónicos, ropa, entre otros. Estos se han visto asociados en alteraciones a nivel hepático, tiroideo, aparato reproductor, atribuyéndole propiedades tirógenicas, estrogénicas y androgénicas viéndose más afectada la población masculina (31,32).…”

Section: Disruptores Endocrinos Y Sus Efectos En El Aparato Reproductorunclassified

“…Uno de los mecanismos planteados por el cual los DE ejercen sus efectos ha sido el "estrés oxidativo", el cual se lo relaciona con alteraciones nocivas a nivel celular y sobre los espermatozoides. Varias investigaciones en modelos animales, principalmente en roedores, han encontrado que la exposición a DE se relaciona con bajos niveles de testosterona, menor cantidad de espermatozoides, distancia anogenital acortada y un mayor riesgo de criptorquidia e hipospadias (31,32).…”

Section: Disruptores Endocrinos Y El Aparato Reproductor Masculinounclassified

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La influencia de los disruptores endocrinos y su interacción con el organismo

Aguinsaca¹,

Molina²,

Hernández³

et al. 2023

Braz. J. Hea. Rev.

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Los disruptores endocrinos son un extenso conjunto de compuestos y mezclas químicas capaces de modular el eje hipotálamo-hipofisario-tiroideo alterando la dinámica hormonal encargada del equilibrio hemostático, reproducción, desarrollo y comportamiento del ser humano. Se localizan de forma natural en el medio ambiente o como resultado de la producción industrial, contaminación hídrica y alimentaria, por lo que se ha evidenciado que el ser humano está sometido a una exposición masiva y universal de estos disruptores a través de la vía materno fetal, metabólica e inhalatoria, en cuya transmisión endógena predomina la línea germinal sobre la genómica, el riesgo de contaminación incrementa con la edad, y a dosis más bajas existe mayor alteración orgánica. Sin embargo, estudios realizados en productos como pesticidas, perclorato, Isoflavonas o Ácidos poliinsaturados, han revelado el papel fundamental de estos compuestos en trastornos tiroideos, de fertilidad, metabolismo, anomalías congénitas, trastornos vasculares y el cáncer. No obstante, aún se desconoce la utilidad y el mecanismo con el que actúan la gran mayoría de estos compuestos, sumado al uso indiscriminado de los mismos y a la falta de regulaciones estatales, por lo que este tema establece un paradigma que debería ser estudiado a profundidad.

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Section: Disruptores Endocrinos Y Sus Efectos En El Aparato Reproductorunclassified

Section: Disruptores Endocrinos Y El Aparato Reproductor Masculinounclassified

La influencia de los disruptores endocrinos y su interacción con el organismo

Aguinsaca¹,

Molina²,

Hernández³

et al. 2023

Braz. J. Hea. Rev.

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“…It is thus likely that PR-A acts predominately as a repressor and PR-B as an activator. A disrupted balance between PR-A and PR-B may lead to several gynecological pathologies, for example, endometriosis and endometrial hyperplasia [ 7 , 8 ]. It has been shown that PR-A can repress not only the transcriptional activity of PR-B but also transcription mediated by the estrogen receptor and glucocorticoid and mineralocorticoid receptors.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

“…The endocrine disrupting properties of various chemicals as well as steroids possessing estrogen activity have recently become more widely known and studied. Estrogens and progestins are often used together in medications, and the release of both natural and synthetic progestogens to the environment should also be taken in account [ 8 ].…”

Section: Endocrine Disruption By Progestins In Wastewatermentioning

confidence: 99%

Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine

Kolátorová

Vítků

Suchopár³

et al. 2022

IJMS

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Progesterone is a steroid hormone traditionally linked with female fertility and pregnancy. In current reproductive medicine, progesterone and its analogues play crucial roles. While the discovery of its effects has a long history, over recent decades, various novel actions of this interesting steroid have been documented, of which its neuro- and immunoprotective activities are the most widely discussed. Discoveries of the novel biological activities of progesterone have also driven research and development in the field of progesterone analogues used in human medicine. Progestogen treatment has traditionally and predominately been used in maintaining pregnancy, the prevention of preterm labor, various gynecological pathologies, and in lowering the negative effects of menopause. However, there are also various other medical fields where progesterone and its analogues could find application in the future. The aim of this work is to show the mechanisms of action of progesterone and its metabolites, the physiological and pharmacological actions of progesterone and its synthetic analogues in human medicine, as well as the impacts of its production and use on the environment.

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“…Bisphenol A (BPA) is one of the main volume chemicals produced worldwide. BPA is a "xenoestrogen" that has weak estrogenic activity due to binding to estrogen receptors and disturbing estrogen metabolism (Varticovski et al 2022). Extensive literature has raised many concerns about its possible implications in the origin of some chronic diseases such as kidney diseases (Moreno-Gómez-Toledano et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Effects of short-term exposure to low doses of bisphenol A on cellular senescence in the adult rat kidney

Núñez

Argüelles

Perillán

2023

Histochem Cell Biol

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Bisphenol A (BPA) is one of the primary chemicals produced by volume worldwide. Extensive literature has raised many concerns about its possible involvement in the pathogenesis of kidney diseases, but its contribution has not been extensively studied. During cellular senescence, the interference of lipofuscin with cellular functions promotes further senescence, causing cellular malfunction. Insulin-like growth factor-1 (IGF-1) plays an important protective role in the setting of kidney injury. The goal of the present work was to evaluate the effects of short-term treatment with low doses of BPA on cellular senescence in adult rat kidneys. Male Wistar rats were injected with vehicle (CONTROL group) or 50 or 500 μg/kg/day of BPA for 1 week (BPA50 and BPA500 groups, respectively). The kidneys were fixed in 4% buffered formaldehyde and embedded in paraffin. Immunohistochemical analyses were performed, and an immunoreactive score (IRS) was calculated. Lipofuscin autofluorescence was used for the study of cellular senescence. The renal cortex showed diffuse autofluorescent lipofuscin signal in the proximal convoluted tubules (PCTs) of males in the BPA50-treated (weak intensity) and BPA500-treated (strong intensity) groups, but not in CONTROL males. Labeling of cortical PCTs with anti-IGF-1 antibodies showed an IRS of 0 in the CONTROL group, but IRSs of 4 and 6 in the BPA50- and BPA500-treated groups, respectively. The present results suggest that low, “safe” doses of BPA induce renal injury, as measured by histological signs of renal changes, increased cellular senescence, and activation of cellular repair systems in PCTs.

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Endocrine disruptors of sex hormone activities

Cited by 31 publications

References 208 publications

La influencia de los disruptores endocrinos y su interacción con el organismo

La influencia de los disruptores endocrinos y su interacción con el organismo

Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine

Effects of short-term exposure to low doses of bisphenol A on cellular senescence in the adult rat kidney

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