Endocrine Disruptors Leading to Obesity and Related Diseases

Petrakis, Dimitris E.; Vassilopoulou, Loukia; Mamoulakis, Charalampos; Psycharakis, Christos; Anifantaki, Aliki; Sifakis, Stavros; Docea, Anca Oana; Tsiaoussis, John; Makrigiannakis, Antonis; Tsatsakis, Aristidis

doi:10.3390/ijerph14101282

Cited by 155 publications

(104 citation statements)

References 154 publications

(159 reference statements)

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“…A great amount of research has therefore been focused on the effect of environmental factors among others, on male reproductive parameters (Sharpe, 2003). A growing body of toxicology data on animals suggests that exposure to EDs are linked to male reproductive system disorders (Petrakis et al, 2017). Human appears to be less susceptible to many compounds compared to other species but the issue of mixed exposures remains an unresolved problem; each ED may be present in modest concentration but total effect may be additive/multiplicative.…”

Section: Urogenital Abnormalitiesmentioning

confidence: 99%

“…The Public Health Risks). Furthermore, epidemiological and experimental studies displayed evidence for carcinogenic effects of exposure to pesticides (Petrakis et al, 2017). Some experimental studies support that there is no evidence for pesticide mutagenicity.…”

Section: Introductionmentioning

confidence: 99%

“…Several classes of pesticides such as 1,2-dibromo-3-chloropropane, vinclozolin, and OPs interfere with normal male reproductive system function (Petrakis et al, 2017), leading to reduction and/or inhibition of spermatogenesis; sperm count, viability, density and motility impairment; abnormal sperm morphology; induction of deoxyribonucleic acid damage; seminiferous tubule degeneration; and reduction of epididymis, prostate or seminal vesicle weight. They may also alter the follicle-stimulating hormone (FSH), the luteinizing hormone (LH), and testosterone levels; lower activity/level of antioxidant enzymes in the testes; and inhibit testicular steroidogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, dichlorodiphenyl-trichloroethane (DDT) and its metabolites have estrogenic effects on males (Mehrpour et al, 2014). Pesticides and EDs have several biological adverse effects in females as well (Petrakis et al, 2017). Most of them are related to the development of the reproductive system and are specifically attributed to folliculogenesis (Sifakis et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Association of pesticide exposure with human congenital abnormalities

Kalliora

Mamoulakis

Vasilopoulos

et al. 2018

Toxicology and Applied Pharmacology

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102

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Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, neurodevelopmental toxicants, immunotoxicants, and carcinogens. We reviewed the international literature on this subject for the years between 1990 and 2017. The studies were considered in this review through MEDLINE and WHO resources. Out of the n = 1817 studies identified, n = 94 were reviewed because they fulfilled criteria of validity and addressed associations of interest. Epidemiological studies have provided limited evidence linking pre- and post-natal exposure to pesticides with cancers in childhood, neurological deficits, fetal death, intrauterine growth restriction, preterm birth, and congenital abnormalities (CAs). In this review, the potential association between pesticide exposure and the appearance of some human CAs (including among others musculoskeletal abnormalities; neural tube defects; urogenital and cardiovascular abnormalities) was investigated. A trend towards a positive association between environmental or occupational exposure to some pesticides and some CAs was detected, but this association remains to be substantiated. Main limitations of the review include inadequate exposure assessment and limited sample size. Adequately powered studies with precise exposure assessments such as biomonitoring, are warranted to clarify with certainty the potential association between pesticide exposure and human CAs.

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Section: Urogenital Abnormalitiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of pesticide exposure with human congenital abnormalities

Kalliora

Mamoulakis

Vasilopoulos

et al. 2018

Toxicology and Applied Pharmacology

Self Cite

102

View full text Add to dashboard Cite

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“…These metabolic derangements are strongly associated with end‐organ manifestations including coronary artery disease, diabetes, nonalcoholic fatty liver disease (NAFLD), and others. Importantly, the cellular signaling and biochemical pathways involved in the metabolic syndrome are complex . Fat deposition in the myocardium, pancreas, liver, and subcutaneous and visceral fat depots are interesting targets for noninvasive assessment using MRI …”

Section: Introductionmentioning

confidence: 99%

Accurate fatty acid composition estimation of adipose tissue in the abdomen based on bipolar multi‐echo MRI

Schneider

Janas

Lugauer

et al. 2018

Magnetic Resonance in Med

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Purpose To develop a bipolar multi‐echo MRI method for the accurate estimation of the adipose tissue fatty acid composition (FAC) using clinically relevant protocols at clinical field strength. Methods The proposed technique jointly estimates confounding factors (field map, R2*, eddy‐current phase) and triglyceride saturation state parameters by fitting multi‐echo gradient echo acquisitions to a complex signal model. The noise propagation behavior was improved by applying a low‐rank enforcing denoising technique and by addressing eddy‐current‐induced phase discrepancies analytically. The impact of the total echo train duration on the FAC parameter map accuracy was analyzed in an oil phantom at 3T. Accuracy and reproducibility assessment was based on in vitro oil phantom measurements at two field strengths (3T and 1.5T) and with two different protocols. Repeatability was assessed in vivo in patients (n = 8) with suspected fatty liver disease using test–retest acquisitions in the abdominal subcutaneous, perirenal and mesenteric fat depots. Results Echo train readout durations of at least five times the conventional in‐phase time were required for accurate FAC estimation in areas of high fat content. In vitro, linear regression and Bland–Altman analyses demonstrated strong (r > 0.94) and significant (P ≪ 0.01) correlations between measured and reference FACs for all acquisitions, with smaller overall intercepts and biases at 3T compared to 1.5T. In vivo, reported mean absolute differences between test and retest were 1.54%, 3.31%, and 2.63% for the saturated, mono‐unsaturated, and poly‐unsaturated fat component, respectively. Conclusions Accurate and reproducible MRI‐based FAC quantification within a breath‐hold is possible at clinical field strengths.

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Per‐ and Polyfluoroalkyl Substance Exposure, Gestational Weight Gain, and Postpartum Weight Changes in Project Viva

Mitro

Sagiv

Rifas‐Shiman

et al. 2020

Obesity

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Objective The purpose of this study was to test the extent to which pregnancy per‐ and polyfluoroalkyl substance (PFAS) concentrations were associated with gestational weight gain and postpartum weight changes. Methods This study was composed of 1,614 women recruited between 1999 and 2002 via the Project Viva cohort with pregnancy plasma concentrations of six PFAS, including perfluorooctanesulfonic acid, perfluorooctanoic acid (PFOA), and 2‐(N‐ethyl‐perfluorooctane sulfonamido) acetic acid. Gestational weight gain was defined as the difference between last pregnancy weight and prepregnancy weight, 1‐year postpartum weight retention as the difference between 1‐year postpartum weight and prepregnancy weight, and 3‐year postpartum weight change as the difference between 3‐year postpartum weight and prepregnancy weight. Results During pregnancy, women gained 0.37 kg (95% CI: 0.11‐0.62) more weight per doubling of 2‐(N‐ethyl‐perfluorooctane sulfonamido) acetic acid. At 1 year post partum, women retained 0.55 kg (95% CI: 0.07‐1.04) more weight per doubling of PFOA. At 3 years post partum, women gained 0.91 kg (95% CI: 0.25‐1.56) more weight per doubling in PFOA. Findings were similar after adjustment for all PFAS. Other PFAS were not associated with weight changes. Postpartum associations were stronger among women with higher prepregnancy BMI. Models were adjusted for demographics. Conclusions Pregnancy PFAS were associated with greater gestational weight gain, weight retention, and weight gain years after pregnancy.

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Endocrine Disruptors Leading to Obesity and Related Diseases

Cited by 155 publications

References 154 publications

Association of pesticide exposure with human congenital abnormalities

Association of pesticide exposure with human congenital abnormalities

Accurate fatty acid composition estimation of adipose tissue in the abdomen based on bipolar multi‐echo MRI

Per‐ and Polyfluoroalkyl Substance Exposure, Gestational Weight Gain, and Postpartum Weight Changes in Project Viva

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