Endocrine Disruptors and Hypospadias: Role of Genistein and the Fungicide Vinclozolin

Vilela, Marcelo; Willingham, Emily; Buckley, Jill C.; Liu, Ben Chun; Agras, Koray; Shiroyanagi, Yoshiyuki; Baskin, Laurence S.

doi:10.1016/j.urology.2007.05.004

Cited by 57 publications

(47 citation statements)

References 14 publications

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“…When two defined mixtures of phytoestrogens and "xeno"ED (designed on the basis of human exposure data) were tested in the uterotrophic assay on prepubertal rats, the phytoestrogen mixture alone elicited an uterotrophic response, whereas the synthetic mixture exerted an effect only in combination with the phytoestrogens, possibly because the levels of exposure were too low [61]. The indices of hypospadias in mice exposed in utero to genistein, the antiandrogenic fungicide vinclozolin or both substances were 25%, 42% and 41%, respectively; based on this parameter, the combined exposure to the phytoestrogen and the environmental antiandrogen had an effect that was less than additive [62]. On the other hand, genistein, as well as the methyl donor folic acid, both antagonized the hypomethylation effect of DNA caused by BPA in mouse embryos [63].…”

Section: The Influence Of Dietary Habits and Of Natural Food Constitumentioning

confidence: 95%

Endocrine Disrupters and Food Safety

Mantovani

2016

TOBIOTJ

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Abstract:The general population is constantly exposed to a mixture of endocrine disrupters (ED), mainly through the food chain.The dietary exposure pathways are diverse, since ED can: i) affect diet components most liable to environmental pollution (e.g., polychlorinated and polybrominated chemicals in lipid-rich foods); ii) be employed in food production (e.g., certain groups of agrochemicals); iii) be released from food contact materials or during food production processes (such as bisphenol A or phthalates); iv) last but not least, be naturally present in food: endocrine-active nutrients and bioactive substances, such as iodine and phytoestrogens, respectively, may elicit health risks when intakes are excessive. Main health concerns from dietary exposure to ED include the building-up of a pollutants body burden and the potential for additive, "cocktail" effects. The factors modulting exposure and susceptibility are considered, including different stages of life, the modulation of risks by dietary habits and the multiple, often inadequately understood, interactions between ED and food components.

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Section: The Influence Of Dietary Habits and Of Natural Food Constitumentioning

confidence: 95%

Endocrine Disrupters and Food Safety

Mantovani

2016

TOBIOTJ

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“…In estrogen reporter (ERE-tKLuciferase) male mice, genistein modulated the actions of both estradiol and persistent ED in a tissue-specific manner: the antiestrogenic actions of beta-hexachlorocyclohexane on the testis and of o,p'-DDT on the liver were antagonized, whereas the effect of genistein on the liver was additive with that of the ER agonist p,p'-DDT on this same organ [60]. When two defined mixtures of phytoestrogens and "xeno" ED (designed on the basis of human exposure data) were tested in the uterotrophic assay on prepubertal rats, the phytoestrogen mixture alone elicited an uterotrophic response, whereas the synthetic mixture exerted an effect only in combination with the phytoestrogens, possibly because the levels of exposure were too low [61].The indices of hypospadias in mice exposed in utero to genistein, the antiandrogenic fungicide vinclozolin or both substances were 25%, 42% and 41%, respectively; based on this parameter, the combined exposure to the phytoestrogen and the environmental antiandrogen had an effect that was less than additive [62]. On the other hand, genistein, as well as the methyl donor folic acid, both antagonized the hypomethylation effect of DNA caused by BPA in mouse embryos [63].…”

Section: The Influence Of Dietary Habits and Of Natural Food Constitumentioning

confidence: 95%

Endocrine Disrupters and Food Safety

Mantovani¹

2015

TOBIOTJ

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The general population is constantly exposed to a mixture of endocrine disrupters (ED), mainly through the food chain.The dietary exposure pathways are diverse, since ED can: i) affect diet components most liable to environmental pollution (e.g., polychlorinated and polybrominated chemicals in lipid-rich foods); ii) be employed in food production (e.g., certain groups of agrochemicals); iii) be released from food contact materials or during food production processes (such as bisphenol A or phthalates); iv) last but not least, be naturally present in food: endocrineactive nutrients and bioactive substances, such as iodine and phytoestrogens, respectively, may elicit health risks when intakes are excessive. Main health concerns from dietary exposure to ED include the building-up of a pollutants body burden and the potential for additive, "cocktail" effects.The factors modulting exposure and susceptibility are considered, including different stages of life, the modulation of risks by dietary habits and the multiple, often inadequately understood, interactions between ED and food components.

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“…In rats exposed in utero, both genistein and the estrogenic chlorinated insecticide methoxychlor exerted an additive effect on the affected cellular parameters related to immunological development, but their additive effect was minimal [64]. The indices of hypospadias in mice exposed in utero to genistein, the antiandrogenic fungicide vinclozolin or both substances were 25, 42 and 41%, respectively; thus, the combined exposure to the phytoestrogen and the environmental antiandrogen had an effect that was less than additive [65]. On the other hand, genistein antagonized the DNA-hypomethylating effect of BPA in mouse embryos; the antagonizing effect of genistein was comparable to that of the methyl donor folic acid [66].…”

Section: Factors Modulating the Ed-associated Health Risks: Life Stagmentioning

confidence: 99%

Endocrine Disrupters and the Safety of Food Chains

Mantovani¹

2015

Horm Res Paediatr

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Endocrine disrupters (ED) are a heterogeneous group of chemicals including persistent contaminants, pesticides, as well as compounds present in consumer products and natural substances. For most ED, the food chain is a current major exposure route for the general population. ED can enter the food chain through the living environment (e.g., feeds, fertilizers) of food-producing organisms, be directly employed in food production (e.g., pesticides) or be released from food contact materials (such as bisphenol A or phthalates); in addition, the endocrine disruption potential of some natural compounds in edible plants, including the so-called phytoestrogens, should not be overlooked. An exposure assessment has to consider the specific liability of food commodities to contamination with specific ED (e.g., polychlorinated and polybrominated chemicals in lipid-rich foods). The paper discusses the main toxicological research issues in order to support the risk assessment of ED in food chains, including: the potential for additive, ‘cocktail' effects (as from multiple pesticide residues); the long-term effects on target body systems (e.g., reproductive, nervous) elicited by exposure during prenatal as well as postnatal life stage windows, and toxicant/nutrient interactions (e.g., thyroid-targeting ED and iodine status). Food safety systems should exploit the available knowledge to improve prevention of long-term risks along the whole food chain.

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Endocrine Disruptors and Hypospadias: Role of Genistein and the Fungicide Vinclozolin

Cited by 57 publications

References 14 publications

Endocrine Disrupters and Food Safety

Endocrine Disrupters and Food Safety

Endocrine Disrupters and Food Safety

Endocrine Disrupters and the Safety of Food Chains

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