Endocrine Disruptive Effects of Polychlorinated Biphenyls on the Thyroid Gland in Female Rats

Kılıç, Nermin; Sandal, Süleyman; Çolakoğlu, Neriman; Kutlu, Selim; Seyran, Ayşe; Yılmaz, Bayram

doi:10.1620/tjem.206.327

Cited by 27 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It alters numbers of estrogen receptor beta immunoreactive cell numbers in the anteroventral periventricular nucleus of the female rat brain, a region important for ovulation in rats (Salama et al, 2003). In addition, A1221 interferes with other endocrine systems and functions including, but not limited to, the thyroid neuroendocrine axis (Kilic et al, 2005); aromatase activity in vitro (Woodhouse and Cooke, 2004); it acts as an androgen receptor antagonist in vitro (Schrader and Cooke, 2003); it is estrogenic in estrogen-sensitive cell preparations (Shekhar et al, 1997); and it can inhibit fertilization of the mouse oocyte (Kholkute et al, 1994). Together, these data suggest the potential for a wide spectrum of A1221 actions on endocrine systems.…”

Section: Properties Of A1221 As An Endocrine-disrupting Chemicalmentioning

confidence: 99%

The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats

Steinberg

Juenger

Gore

2007

Hormones and Behavior

View full text Add to dashboard Cite

Polychlorinated biphenyls (PCBs) are a family of toxicants that persist in measurable quantities in human and wildlife tissues, despite their ban in production in 1977. Some PCB mixtures can act as endocrine disrupting chemicals (EDCs) by mimicking or antagonizing the actions of hormones in the brain and periphery. When exposure to hormonally active substances such as PCBs occurs during vulnerable developmental periods, particularly prenatally or in early postnatal life, they can disrupt sex-specific patterning of the brain, inducing permanent changes that can later be manifested as improper sexual behaviors. Here, we investigated the effects of prenatal exposure to the PCB mixture Aroclor (A) 1221 on adult female reproductive behaviors in a dose-response model in the SpragueDawley rat. Using a paced mating paradigm that permits the female to set the timing of mating and control contact with the male during copulation, we were able to uncover significant differences in female-typical sexual activities in A1221-exposed females. Specifically, A1221 causes significant effects on mating trial pacing, vocalizations, ambulation and the female's likelihood to mate. The results further demonstrate that the intermediate treatment group has the greatest number of disrupted endpoints, suggestive of non-linear dose responses to A1221. These data demonstrate that the behavioral phenotype in adulthood is disrupted by low, ecologically relevant exposures to PCBs, and the results have implications for reproductive success and health in wildlife and women. KeywordsAroclor 1221; Paced mating; PCB; Female reproductive behavior; Endocrine disruption Polychlorinated biphenyls (PCBs) were used in industry as inflammable coolants and lubricants and as components of paints and plastics. Banned in 1977 in response to dawning public awareness of their estrogenic and potentially toxic effects on humans and wildlife, PCBs continue to leach into soil, air and groundwater via retired industrial equipment, and from old factories and buildings. PCBs may have variable degrees of impact depending on which congeners or congener mixtures are involved, the organism's age at exposure, the sex of the individual, the degree of exposure and the availability of compensatory diet or social buffering to counteract those effects. An accurate evaluation of ecologically relevant xenobiotic exposure (Battershill, 1994;Brouwer et al., 1999).The neuroendocrine system serves as an interface between the central nervous system and peripheral endocrine organs, and thus represents a prime target for endocrine disruption by PCBs (Patisaul et al., 2006). PCBs and their metabolites can act at multiple nodes of the neuroendocrine axis: they may serve as hormone mimics (Connor et al., 1997), alter circulating hormone levels (Desaulniers et al., 1999), change patterns of estrous cyclicity (Meerts et al., 2004;Buitenhuis et al., 2004), disrupt hormone metabolism Kester et al., 2000;Yamane et al., 1975), influence endocrine-related and hypothalamic gene expression ...

show abstract

Section: Properties Of A1221 As An Endocrine-disrupting Chemicalmentioning

confidence: 99%

The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats

Steinberg

Juenger

Gore

2007

Hormones and Behavior

View full text Add to dashboard Cite

show abstract

“…Moreover, studies on the relationship between exposure to PCB and TSH concentration carried out in humans showed confl icting results as well [14,15] . Histopathological changes of the thyroid glands indicative of hyperactivity were found after both oral and s. c. exposure of PCBs in rats [1,9] while monkeys exposed orally to PCBs for 18 -23 weeks showed histopathological changes compatible with induced hypothyroidism [11] . Moreover, the…”

Section: Polychlorinated Biphenyls Aff Ect Thyroid Function and Inducmentioning

confidence: 97%

“…However, there are controversies regarding the defi nite impact of PCBs on the thyroid. Most studies found signifi cantly decreased levels of serum thyroid hormones (THs) in rodents following PCBs exposure [1,2,7,8] while others showed an increase of FT3, FT4, T4 levels [9] or no signifi cant alteration of T4 levels [10] after treatment with PCBs. Some reports showed a positive correlation between PCBs exposure and thyroid stimulating hormone (TSH) [10 -12] .…”

Section: Polychlorinated Biphenyls Aff Ect Thyroid Function and Inducmentioning

confidence: 99%

Polychlorinated Biphenyls Affect Thyroid Function and Induce Autoimmunity in Sprague-Dawley Rats

Gu¹,

Qian²,

Tang³

et al. 2009

Horm Metab Res

View full text Add to dashboard Cite

Polychlorinated biphenyls (PCBs) have been reported to cause a variety of toxic effects. In order to assess the thyroid function after exposure to PCBs and investigate whether PCBs induce autoimmune process in the thyroid gland, we determined the levels of serum thyroid hormones (FT3, FT4, and T4), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibody (TPOAb) in Sprague-Dawley rats treated with a commercial mixture of PCBs, Aroclor 1,254 (PCBs group), or the antithyroid drug, propylthiouracil (PTU group). The histopathology of the thyroid was also examined. Serum FT3, FT4, and T4 concentrations were significantly reduced, while TSH values were dramatically increased in PCBs group and PTU group compared with control rats (p < 0.05). TPOAb levels were significantly elevated in PCBs-treated rats (p < 0.05) but not in PTU group (p > 0.05). In contrast to the controls, treatment with PCBs lead to distinct histopathological changes in the thyroid gland, such as hyperplasia of the epithelia in follicles, colloid content reduction, vascularization, and lymphocytic infiltration in the perifollicular areas, whereas the major changes in the thyroid in PTU-treated rats were follicles shrinkage or collapse and colloid content reduction compatible with induced hypothyroidism. The results indicate that PCBs affect thyroid function via the induction of autoimmunity, which is a mechanism different from the effect of antithyroid drug on the thyroid gland.

show abstract

“…A growing body of evidence strongly supports effects of EDCs on reproductive and endocrine function in vivo, and in in vitro models (Gore, 2002b;Kholkute et al, 1994;Kilic et al, 2005;Shekhar et al, 1997;Woodhouse and Cooke, 2004;reviewed in Dickerson and Gore (2007) and Walker and Gore (2007)). Whereas much of the original endocrine disruption work showed effects on vitellogenesis (fish), reproductive tract, genitalia, serum hormone levels, and reproductive developmental landmarks (e.g., timing of puberty), little of this work focused on the effects of EDCs on the neuroendocrine control of reproduction.…”

Section: Neuroendocrine Effects Of Edcs On the Hypothalamic-pituitarymentioning

confidence: 99%

Environmental Endocrine Disruption of Brain and Behavior

Gore¹,

Crews

2009

Hormones, Brain and Behavior

View full text Add to dashboard Cite

Endocrine Disruptive Effects of Polychlorinated Biphenyls on the Thyroid Gland in Female Rats

Cited by 27 publications

References 24 publications

The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats

The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats

Polychlorinated Biphenyls Affect Thyroid Function and Induce Autoimmunity in Sprague-Dawley Rats

Environmental Endocrine Disruption of Brain and Behavior

Contact Info

Product

Resources

About