Endocrine Disruption in the Omics Era: New Views, New Hazards, New Approaches

Oliveira, Eva; Barata, Carlos; Piña, Benjamı́n

doi:10.2174/1874070701610010020

Cited by 11 publications

(6 citation statements)

References 80 publications

(61 reference statements)

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“…Gene expression patterns induced by different mixtures of endocrine-disrupting chemicals were analyzed using a commercial microarray designed to study the transcription of the rat brain. A combination was found of altered pathways associated with cell death and inflammation [57], consistent with the known ability of many pollutants to alter the hormonal balance of organisms [20].…”

Section: Illustrative Case #supporting

confidence: 56%

“…The analysis of the effect of toxicants on the relative abundance of mRNA of specific genes has become a major technique for assessing their physiological impact on a variety of environmental and toxicology-relevant animal and plant species [2,20,21]. The simplest and most widely-used technique for this is the real-time quantitative polymerase chain reaction (qPCR).…”

Section: Transcriptomicsmentioning

confidence: 99%

“…Various pollutants are known to alter the hormonal balance of organisms [20]. Gene expression patterns induced by different mixtures of endocrine-disrupting chemicals were analyzed using a commercial microarray designed to study the transcription of the rat brain.…”

Section: Illustrative Case #mentioning

confidence: 99%

See 2 more Smart Citations

Perspectives on the Use of Toxicogenomics to Assess Environmental Risk

Portugal¹,

Mansilla²,

Piña³

2022

Front. Biosci. (Landmark Ed)

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Environmental toxicogenomics aims to collect, analyze and interpret data on changes in gene expression and protein activity resulting from exposure to toxic substances using high-performance omics technologies. Molecular profiling methods such as genomics, transcriptomics, proteomics, metabolomics, and bioinformatics techniques, permit the simultaneous analysis of a multitude of gene variants in an organism exposed to toxic agents to search for genes prone to damage, detect patterns and mechanisms of toxicity, and identify specific gene expression profiles that can provide biomarkers of exposure and risk. Compared to previous approaches to measuring molecular changes caused by toxicants, toxicogenomic technologies can improve environmental risk assessment while reducing animal studies. We discuss the prospects and limitations of converting omic datasets into valuable information, focusing on assessing the risks of mixed toxic substances to the environment and human health.

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Section: Illustrative Case #supporting

confidence: 56%

Section: Transcriptomicsmentioning

confidence: 99%

See 1 more Smart Citation

Perspectives on the Use of Toxicogenomics to Assess Environmental Risk

Portugal¹,

Mansilla²,

Piña³

2022

Front. Biosci. (Landmark Ed)

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“…Likewise, policies that must be made by the institution or organisation concerned are related to their management. Then, human resources must also get attention because it is the person who took part in the continuation of the Cyber University [19].…”

Section: Ii4 Aspects Of the Higher Education Systemmentioning

confidence: 99%

Systematic Literature Review of Disruption Era in Indonesia: The Resistance of Industrial Revolution 4.0

Fadilurrahman

Ramadhani

Kurniawan

et al. 2021

jrc

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The plethora of research in the multidisciplinary fields has been proved the disruption era. However, it might be several boundaries in the global context. Thus, this research attempts to identify dominant fields which consist of implementing the law, governance, management trajectory, and system of higher education in Indonesia. Furthermore, the qualitative method of the systematic literature review is used to examine the implication, and therefore this study produces four findings. Firstly, the most prominent enabling contexts are to ensure the implementation of the law and the conceptualization of policies. Secondly, adopting effective and efficient bureaucracy bases on electronic governance (e-governance). Thirdly, management trajectory has been aimed to fill the gaps in this context. Finally, this study also intends to unveil preliminary actions toward higher education system by networking infrastructures. The outcomes might be considered as pathways for accelerating the progress related to authorities, companies, and institutions. By way of conclusion, in order to attain better provision, measuring the process of Indonesia disruption realm is a critical phase to elucidate the current circumstance, elaborate the gaps, and foresee the priority actions concerning the disruption era in Indonesia.

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“…Untargeted metabolomics offers a powerful approach to broadly explore how pollutants influence physiological and metabolic endpoints in wildlife (Oliveira et al, 2016). Nuclear magnetic resonance (NMR) spectroscopy is a convenient option for metabolite profiling due to relatively simple sample processing and a high level of repeatability, and has proven very useful for applications in ecotoxicology (Emwas et al, 2013;Lankadurai et al, 2013;Viant et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Metabolite profiles of striped marsh frog (Limnodynastes peronii) larvae exposed to the anti-androgenic fungicides vinclozolin and propiconazole are consistent with altered steroidogenesis and oxidative stress

2018

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Amphibians use wetlands in urban and agricultural landscapes for breeding, growth and development. Fungicides and other pesticides used in these areas have therefore been identified as potential threats that could contribute towards amphibian population declines. However, relatively little is known about how such chemicals influence sensitive early life-stages or how short episodic exposures influence sub-lethal physiological and metabolic pathways. The present study applied untargeted metabolomics to evaluate effects in early post-hatch amphibian larvae exposed to the anti-androgenic fungicides vinclozolin and propiconazole. Recently hatched (Gosner developmental stage 25) striped marsh frog (Limnodynastes peronii) larvae were exposed for 96 h to vinclozolin at 17.5, 174.8 and 1748.6 nM and propiconazole at 5.8, 58.4 and 584.4 nM. Nuclear Magnetic Resonance (NMR) spectroscopy was performed on polar metabolites obtained from whole-body extracts. Both fungicides altered metabolite profiles compared to control animals at all concentrations tested, and there were notable differences between the two chemicals. Overall responses were consistent with altered steroidogenesis and/or cholesterol metabolism, with inconsistent responses between the two fungicides likely reflecting minor differences in the mechanisms of action of these chemicals. Broad down-regulation of the tricarboxylic acid (TCA) cycle was also observed and is indicative of oxidative stress. Interestingly, formic acid was significantly increased in larvae exposed to vinclozolin but not propiconazole, suggesting this metabolite may serve as a useful biomarker of exposure to androgen-receptor binding anti-androgenic contaminants. This study demonstrates the power of untargeted metabolomics for distinguishing between similarly acting, but distinct, pollutants and for unraveling non-endocrine responses resulting from exposure to known endocrine active contaminants.

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Endocrine Disruption in the Omics Era: New Views, New Hazards, New Approaches

Cited by 11 publications

References 80 publications

Perspectives on the Use of Toxicogenomics to Assess Environmental Risk

Perspectives on the Use of Toxicogenomics to Assess Environmental Risk

Systematic Literature Review of Disruption Era in Indonesia: The Resistance of Industrial Revolution 4.0

Metabolite profiles of striped marsh frog (Limnodynastes peronii) larvae exposed to the anti-androgenic fungicides vinclozolin and propiconazole are consistent with altered steroidogenesis and oxidative stress

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