Endocrine Disruption in Molluscs: Processes and Testing

McClellan‐Green, Patricia

doi:10.1002/9781118355961.ch6

Cited by 5 publications

(2 citation statements)

References 141 publications

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“…Much of this has arisen using this group in mariculture industries. Furthermore, the molluscan endocrine system, and its disruption, is probably better understood than that of any other invertebrate phylum except the arthropods (McClellan‐Green, 2013 ).…”

Section: Evaluation Of Existing Invertebrate Test Methods For Their P...mentioning

confidence: 99%

Thyroid‐like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Morthorst

Holbech

Crozé

et al. 2022

Integr Envir Assess & Manag

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This review examines the presence and evolution of thyroid-like systems in selected aquatic invertebrates to determine the potential use of these organisms in screens for vertebrate thyroid hormone axis disrupting chemicals (THADCs). Such a screen might support the phasing out of some vertebrate testing. Although arthropods including crustaceans do not contain a functional thyroid signaling system, elements of such a system exist in the aquatic phyla mollusks, echinoderms, tunicates, and cephalochordates. These phyla can synthesize thyroid hormone, which has been demonstrated in some groups to induce the nuclear thyroid hormone receptor (THR). Thyroid hormone may act in these phyla through interaction with a membrane integrin receptor. Thyroid hormone regulates inter alia metamorphosis but, unlike in vertebrates, this does not occur via receptor activation by the ligands triiodothyronine (T3) and thyroxine (T4). Instead, the unliganded nuclear receptor itself controls metamorphosis in mollusks, echinoderms, and tunicates, whereas the T3 derivative tri-iodothyroacetic acid (TRIAC) acts as a THR ligand in cephalochordates. In view of this, it may be possible to develop an invertebrate-based screen that is sensitive to vertebrate THADCs that interfere with thyroid hormone synthesis or metabolism along with interaction with membrane receptors. The review makes some recommendations for the need to develop an appropriate test method.

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Section: Evaluation Of Existing Invertebrate Test Methods For Their P...mentioning

confidence: 99%

Thyroid‐like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Morthorst

Holbech

Crozé

et al. 2022

Integr Envir Assess & Manag

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show abstract

“…In addition, exposure to one or more etiologic agents (e.g., physical, chemical, biological, etc.) may expose invertebrates to disease [27][28][29]. The effects and interactions between pollution and pathogens can have significant effects on the ecology and physiology of both farmed and wild molluscs [30].…”

Section: Introductionmentioning

confidence: 99%

Environmental Stressors and Pathology of Marine Molluscs

Esposito

Pastorino

Prearo

2022

JMSE

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Validation of the OECD reproduction test guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz

et al. 2017

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The Organisation for Economic Cooperation and Development (OECD) provides several standard test methods for the environmental hazard assessment of chemicals, mainly based on primary producers, arthropods, and fish. In April 2016, two new test guidelines with two mollusc species representing different reproductive strategies were approved by OECD member countries. One test guideline describes a 28-day reproduction test with the parthenogenetic New Zealand mudsnail Potamopyrgus antipodarum. The main endpoint of the test is reproduction, reflected by the embryo number in the brood pouch per female. The development of a new OECD test guideline involves several phases including inter-laboratory validation studies to demonstrate the robustness of the proposed test design and the reproducibility of the test results. Therefore, a ring test of the reproduction test with P. antipodarum was conducted including eight laboratories with the test substances trenbolone and prochloraz and results are presented here. Most laboratories could meet test validity criteria, thus demonstrating the robustness of the proposed test protocol. Trenbolone did not have an effect on the reproduction of the snails at the tested concentration range (nominal: 10-1000 ng/L). For prochloraz, laboratories produced similar EC and NOEC values, showing the inter-laboratory reproducibility of results. The average EC and NOEC values for reproduction (with coefficient of variation) were 26.2 µg/L (61.7%) and 29.7 µg/L (32.9%), respectively. This ring test shows that the mudsnail reproduction test is a well-suited tool for use in the chronic aquatic hazard and risk assessment of chemicals.

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Endocrine Disruption in Molluscs: Processes and Testing

Cited by 5 publications

References 141 publications

Thyroid‐like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Thyroid‐like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Environmental Stressors and Pathology of Marine Molluscs

Validation of the OECD reproduction test guideline with the New Zealand mudsnail Potamopyrgus antipodarum using trenbolone and prochloraz

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