Endocrine Disruption and the Gut Microbiome

Acharya, Kalpana D.; Parakoyi, Abigail E.R.; Tetel, Marc J.

doi:10.1016/b978-0-12-821985-0.00015-3

Cited by 6 publications

(10 citation statements)

References 145 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Environmental pollutants might also be ingested with water or even air pollutants inhaled (i.e. particulate matter (PM)), and as a consequence alter gut microbial composition and abundance (Acharya et al, 2022). Moreover, over the decades, substantial modifications have been introduced in food production and processing, lifestyle, family structure and the environment that could directly affect the gut microbiome (Acharya et al, 2022).…”

Section: Cumulative Exposure To Xenobiotics Under One Healthmentioning

confidence: 99%

“…The human gut microbiota, meaning microorganisms inhibiting human intestines, is estimated to contain up to 10 14 microbial cells/g (Valdes et al, 2018), mostly commensal or mutualistic microorganisms (Fan and Pedersen, 2021), representing over 1,000 different species, many of them showing relevant functionalities (Aguilera et al, 2012). In addition, the human gut microbiome refers to the collective genomes of the microorganisms and their metabolites in the gastrointestinal tract (Valdes et al, 2018;Acharya et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microbiota analysis for risk assessment of xenobiotics: cumulative xenobiotic exposure and impact on human gut microbiota under One Health approach

Gruszecka‐Kosowska

Ampatzoglou

Aguilera‐Gómez

2022

EFS2

View full text Add to dashboard Cite

Human gut microbiota is the microbial community that, through the constant bidirectional communication with its host, plays the critical role of maintaining the state of eubiosis and health balance, contributing to food digestion, detoxification, and proper endocrine, neurological, immunological and potentially reproductive health. To this extent, gut microbiota is called the ‘second brain’ as well as the ‘second liver’. Xenobiotics, including environmental pollutants, are widely spread in the environment and easily accessible in food, cosmetics, personal care products, drugs and medicinal products. Thus, the gut microbiota can be exposed to these xenobiotics, which in turn might alter its composition and metabolism that can trigger dysbiosis, and they seem associated with disorders and diseases in the host. A specific group of xenobiotics, called endocrine‐disrupting chemicals, is particularly important due to relevant adverse health effects. A considerable challenge in risk assessment is the combined exposure to xenobiotics, for which the integrated approaches, including the One Health concept, are still under development. Nevertheless, recent research advancements focus on molecular data in the search for elucidating crucial microbiome biomarkers, associated with physiopathology and specific dysfunctions triggered by xenobiotic exposure. In this context, the application of meta‐omics and integration of genomics, metagenomics, metabolomics, metatranscriptomics, proteomics and multidisciplinary approaches are particularly important.

show abstract

Section: Cumulative Exposure To Xenobiotics Under One Healthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbiota analysis for risk assessment of xenobiotics: cumulative xenobiotic exposure and impact on human gut microbiota under One Health approach

Gruszecka‐Kosowska

Ampatzoglou

Aguilera‐Gómez

2022

EFS2

View full text Add to dashboard Cite

show abstract

“…The differences between the present and previous studies could also be due to the use of antibiotics for initial depletion of the native gut microbiota prior to A. muciniphila gavage in the current study unlike in previous studies ( 17 , 19 ). Antibiotics interact with estrogens ( 34 , 68 , 69 ), primarily by altering the composition of the gut microbiota and E2 metabolism. In support, the mammalian gut is ubiquitously colonized by microbes that produce the steroid-metabolizing enzyme, β -glucuronidase, which is responsible for the deconjugation and reuptake of E2 in enterohepatic circulation ( 34 , 70 – 72 ).…”

Section: Discussionmentioning

confidence: 99%

“…Antibiotics interact with estrogens ( 34 , 68 , 69 ), primarily by altering the composition of the gut microbiota and E2 metabolism. In support, the mammalian gut is ubiquitously colonized by microbes that produce the steroid-metabolizing enzyme, β -glucuronidase, which is responsible for the deconjugation and reuptake of E2 in enterohepatic circulation ( 34 , 70 – 72 ). β -glucuronidase activity has been observed in Bacteroides and Ruminococcus ( 73 ), which were decreased by antibiotics in the present study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differential effects of Akkermansia-enriched fecal microbiota transplant on energy balance in female mice on high-fat diet

Acharya

Friedline²,

Ward³

et al. 2022

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

Estrogens protect against weight gain and metabolic disruption in women and female rodents. Aberrations in the gut microbiota composition are linked to obesity and metabolic disorders. Furthermore, estrogen-mediated protection against diet-induced metabolic disruption is associated with modifications in gut microbiota. In this study, we tested if estradiol (E2)-mediated protection against obesity and metabolic disorders in female mice is dependent on gut microbiota. Specifically, we tested if fecal microbiota transplantation (FMT) from E2-treated lean female mice, supplemented with or without Akkermansia muciniphila, prevented high fat diet (HFD)-induced body weight gain, fat mass gain, and hyperglycemia in female recipients. FMT from, and cohousing with, E2-treated lean donors was not sufficient to transfer the metabolic benefits to the E2-deficient female recipients. Moreover, FMT from lean donors supplemented with A. muciniphila exacerbated HFD-induced hyperglycemia in E2-deficient recipients, suggesting its detrimental effect on the metabolic health of E2-deficient female rodents fed a HFD. Given that A. muciniphila attenuates HFD-induced metabolic insults in males, the present findings suggest a sex difference in the impact of this microbe on metabolic health.

show abstract

Diverse mechanisms by which chemical pollutant exposure alters gut microbiota metabolism and inflammation

Teffera,

Veith,

Ronnekleiv-Kelly

et al. 2024

Environment International

View full text Add to dashboard Cite

Endocrine Disruption and the Gut Microbiome

Cited by 6 publications

References 145 publications

Microbiota analysis for risk assessment of xenobiotics: cumulative xenobiotic exposure and impact on human gut microbiota under One Health approach

Microbiota analysis for risk assessment of xenobiotics: cumulative xenobiotic exposure and impact on human gut microbiota under One Health approach

Differential effects of Akkermansia-enriched fecal microbiota transplant on energy balance in female mice on high-fat diet

Diverse mechanisms by which chemical pollutant exposure alters gut microbiota metabolism and inflammation

Contact Info

Product

Resources

About