2017
DOI: 10.1007/10_2016_2
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Endocrine Disruption and In Vitro Ecotoxicology: Recent Advances and Approaches

Abstract: Endocrine-disrupting chemicals (EDCs) are man-made compounds interfering with hormone signaling. Omnipresent in the environment, they can cause adverse effects in a wide range of wildlife. Accordingly, Endocrine Disruption is one focal area of ecotoxicology. Because EDCs induce complex response patterns in vivo via a wide range of mechanisms of action, in vitro techniques have been developed to reduce and understand endocrine toxicity. In this review we revisit the evidence for endocrine disruption in diverse … Show more

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Cited by 10 publications
(11 citation statements)
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“…Assays for estrogenic activity evaluation have been described in recent review articles (Mueller 2004, Kiyama and Wada-Kiyama 2015, Wagner et al 2017, Wangmo et al 2018. For the assessment of the estrogenic activity in biological samples, three kinds of assays have been applied: ligand-binding assays, gene reporter assays and proliferation assays (E-screen assays).…”
Section: Assays For Estrogenic Activity Evaluationmentioning
confidence: 99%
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“…Assays for estrogenic activity evaluation have been described in recent review articles (Mueller 2004, Kiyama and Wada-Kiyama 2015, Wagner et al 2017, Wangmo et al 2018. For the assessment of the estrogenic activity in biological samples, three kinds of assays have been applied: ligand-binding assays, gene reporter assays and proliferation assays (E-screen assays).…”
Section: Assays For Estrogenic Activity Evaluationmentioning
confidence: 99%
“…The first E-screen assay was developed by Soto et al (1997) using human breast cancer cells (MCF-7), whose proliferation is mainly induced by the activation of ERα (Wagner et al 2017).…”
Section: Proliferation Assays (E-screen Assays)mentioning
confidence: 99%
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“…Among pollutants discharged into the environment, many belong to the family of endocrine disruptors (EDs), chemicals able to lead to endocrine disorders in both humans [4] and wildlife [5], even at trace levels. Polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and phthalates are such chemicals, which have been quantified both in water and the roach Rutilus rutilus in the Seine basin [6].…”
Section: Value Of In Vitro Bioassays For An Ex Situ Evaluation Of Water Contamination: the Case Of Endocrine Disruptorsmentioning
confidence: 99%
“…Also, as a result of expensive animal test costs and longer test time of in vivo assays (animal test), in vitro bioassays have become more popular and been recommended by the United States Environmental Protection Agency (U.S. EPA) as screening tools for suspected estrogenic chemicals since 1998. , Therefore, this review focuses on the in vitro assays for screening endocrine disruption of BPA alternatives. In light of different detection end points and mechanisms, there are five major types of effective in vitro assays, including ligand binding assay, reporter gene assay, cell proliferation assay, enzyme assay, and steroidogenesis. ,, Because the enzyme assay [ethoxyresorufin- O -deethylase (EROD) assay] was rarely used for the evaluation of the endocrine disruption of BPA and its alternatives, it was not be reviewed in this paper. For the sake of convenience and clarity, the identification of disruptive endocrine effects via the different receptors is discussed under the four types of in vitro assays.…”
Section: Evaluation Of Endocrine Disruptionmentioning
confidence: 99%