Endocrine disruption and cognitive function in adolescent female rhesus monkeys

Golub, Mari S.; Germann, Stacey L.; Hogrefe, Casey E.

doi:10.1016/j.ntt.2004.07.006

Cited by 35 publications

(28 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, women with Turner's syndrome, who are deficient in E2, exhibit hearing disorders and lower auditory processing efficiency (Hultcrantz et al, 1994;Hultcrantz and Sylvén, 1997;Güngör et al, 2000). These findings are consistent with results obtained in rodents and monkeys, in which ovariectomy alters ABRs (Coleman et al, 1994;Golub et al, 2004); after E2 replacement, however, normal ABRs are reinstated (Coleman et al, 1994). Finally, E2 treatment of nonreproductive female midshipman fish tunes behaviorally relevant auditory processing (Sisneros et al, 2004).…”

Section: Introductionsupporting

confidence: 84%

Estradiol Shapes Auditory Processing in the Adult Brain by Regulating Inhibitory Transmission and Plasticity-Associated Gene Expression

Tremere¹,

Jeong²,

Pinaud³

2009

J. Neurosci.

135

219

View full text Add to dashboard Cite

Estradiol impacts a wide variety of brain processes, including sex differentiation, mood, and learning. Here we show that estradiol regulates auditory processing of acoustic signals in the vertebrate brain, more specifically in the caudomedial nidopallium (NCM), the songbird analog of the mammalian auditory association cortex. Multielectrode recordings coupled with local pharmacological manipulations in awake animals reveal that both exogenous and locally generated estradiol increase auditory-evoked activity in NCM. This enhancement in neuronal responses is mediated by suppression of local inhibitory transmission. Surprisingly, we also found that estradiol is both necessary and sufficient for the induction of multiple mitogen-activated protein kinase (MAPK)-dependent genes thought to be required for synaptic plasticity and memorization of birdsong. Specifically, we show that local blockade of estrogen receptors or aromatase activity in awake birds decrease song-induced MAPK-dependent gene expression. Infusions of estradiol in acoustically isolated birds induce transcriptional activation of these genes to levels comparable with song-stimulated animals. Our results reveal acute and rapid nongenomic functions for estradiol in central auditory physiology and suggest that such roles may be ubiquitously expressed across sensory systems.

show abstract

Section: Introductionsupporting

confidence: 84%

Estradiol Shapes Auditory Processing in the Adult Brain by Regulating Inhibitory Transmission and Plasticity-Associated Gene Expression

Tremere¹,

Jeong²,

Pinaud³

2009

J. Neurosci.

135

219

View full text Add to dashboard Cite

show abstract

“…Accordingly, although much less attention has been paid to outcomes in female offspring, the present results indicate that they are equally likely to show longterm anomalies, albeit with a different, and even opposite, spectrum of effects from those seen in males. Indeed, some of the effects of antenatal glucocorticoids may then resemble those of environmental estrogens, which are known to alter cognitive performance and motor activity in females (Golub et al, 2004;Masuo et al, 2004). The pattern seen here, negation of sex differences, mimics that seen with chlorpyrifos, an organophosphorus insecticide completely unrelated to dexamethasone, but that similarly interferes with sexual differentiation of the brain (Levin et al, 2001(Levin et al, , 2002Slotkin, 2005).…”

Section: Discussionmentioning

confidence: 59%

Gestational Dexamethasone Treatment Elicits Sex-Dependent Alterations in Locomotor Activity, Reward-Based Memory and Hippocampal Cholinergic Function in Adolescent and Adult Rats

Kreider

Levin

Seidler

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Glucocorticoids are the consensus treatment for preventing respiratory distress syndrome in preterm infants but there is emerging evidence of subsequent neurobehavioral abnormalities, independent of somatic growth effects. Pregnant rats were given 0.2 mg/kg of dexamethasone, a dose commensurate with clinical use, on gestational days 17-19 and behavioral evaluations were made on the offspring in adolescence and adulthood. The dexamethasone groups had the same body weights as the controls but nevertheless displayed long-term, sex-selective alterations in locomotor and cognitive behaviors. In the figure-8 activity apparatus, dexamethasone treatment ablated the normal sex differences in locomotor activity by reducing values in females to the lower level typical of males; habituation of activity similarly was impaired in females, reducing the profile to match that of control males, while male rats in the dexamethasone group showed a partially feminized pattern of habituation. In the 8-arm radial maze, control rats displayed typical sex differences, with male rats performing more accurately than females. Dexamethasone treatment eliminated this normal dichotomy, delaying learning in males while improving performance in females to the level normally seen in control males. Finally, we assessed hippocampal [3 H]hemicholinium-3 binding as a biomarker for cholinergic synaptic activity, and again found loss of sex differences in the dexamethasone group: values in males were increased to the higher levels typical of females. These results indicate that gestational treatment with dexamethasone obtunds the normal sex differences in neurochemistry and behavior that are typically seen in adolescence in adulthood, thus producing sex-selective alterations in activity, learning, and memory.

show abstract

“…9,10 Epiphyseal closure and cessation of long bone growth also have been assessed. 11 In male monkeys, increases in testicular volume indicate onset of male puberty and reflect both gonadotropin-and testosterone-mediated events. 12 Measurement of changes in testicular size seems to be a reliable, noninvasive procedure to detect the initiation of puberty in both human and nonhuman primates.…”

Section: Figurementioning

confidence: 99%

“…Future research needs are discussed elsewhere in this issue but underscore the need to develop behavioral, psychosocial, and neurologic end points along with the social and psychological consequences of precocious or delayed puberty. 11 Last, regardless of the research question, newly designed animal and human research must use the best available methods. With regard to animal research, careful attention to choice of the most appropriate animal model, relevant critical or sensitive windows of exposure, route and duration of exposure, timing and relevant dosages, assumptions regarding the dose-response curve, and an analytic statistical plan that is responsive to the study design, particularly assessment of mixtures and litter effects, is needed.…”

Section: Research Priorities and Future Directionsmentioning

confidence: 99%

Environmental Factors and Puberty Timing: Expert Panel Research Needs

et al. 2008

Self Cite

View full text Add to dashboard Cite

Serono Symposia International convened an expert panel to review the impact of environmental influences on the regulation of pubertal onset and progression while identifying critical data gaps and future research priorities. An expert panel reviewed the literature on endocrine-disrupting chemicals, body size, and puberty. The panel concluded that available experimental animal and human data support a possible role of endocrine-disrupting chemicals and body size in relation to alterations in pubertal onset and progression in boys and girls. Critical data gaps prioritized for future research initiatives include (1) etiologic research that focus on environmentally relevant levels of endocrine-disrupting chemicals and body size in relation to normal puberty as well as its variants, (2) exposure assessment of relevant endocrine-disrupting chemicals during critical windows of human development, and (3) basic research to identify the primary signal(s) for the onset of gonadotropinreleasing hormone-dependent/central puberty and gonadotropin-releasing hormone-independent/peripheral puberty. Prospective studies of couples who are planning pregnancies or pregnant women are needed to capture the continuum of exposures at critical windows while assessing a spectrum of pubertal markers as outcomes. Coupled with comparative species studies, such research may provide insight regarding the causal ordering of events that underlie pubertal onset and progression and their role in the pathway of adult-onset disease.

show abstract

Endocrine disruption and cognitive function in adolescent female rhesus monkeys

Cited by 35 publications

References 55 publications

Estradiol Shapes Auditory Processing in the Adult Brain by Regulating Inhibitory Transmission and Plasticity-Associated Gene Expression

Estradiol Shapes Auditory Processing in the Adult Brain by Regulating Inhibitory Transmission and Plasticity-Associated Gene Expression

Gestational Dexamethasone Treatment Elicits Sex-Dependent Alterations in Locomotor Activity, Reward-Based Memory and Hippocampal Cholinergic Function in Adolescent and Adult Rats

Environmental Factors and Puberty Timing: Expert Panel Research Needs

Contact Info

Product

Resources

About