Endocrine disruption and altered gonadal development in white perch (Morone americana) from the lower Great Lakes region.

Kavanagh, Richard; Balch, Gordon C.; Kiparissis, Yiannis; Niimi, A. J.; Sherry, James; Tinson, Cheryl; Metcalfe, Chris D.

doi:10.1289/ehp.6514

Cited by 99 publications

(65 citation statements)

References 42 publications

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“…The most commonly reported effects are those resulting from exposure to estrogenic/antiandrogenic chemicals. Feminization of male fishes as evidenced by testicular oocytes or intersex (Jobling et al, 1998;Kavanagh et al, 2004;Dietrich and Krieger, 2009;Blazer et al, 2012) and production of Vtg (Denslow et al, 1999;Jones et al, 2000;Dang et al, 2011;Vajda et al, 2011) has been observed in numerous fish species. In a few cases, population effects are reported (Kidd et al, 2007;An et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay

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Pinkney

Jenkins

et al. 2013

Science of The Total Environment

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Iwanowicz, Luke R.; Minkkinen, Steven; Draugelis-Dale, Rassa O.; and Uphoff, James H., "Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay" (2013 H I G H L I G H T S► Reduced recruitment of yellow perch has occurred in urban tributaries of Chesapeake Bay. ► We compared reproductive health biomarkers in perch from two urban, one developing, two less developed watersheds. ► Lack of final maturation, abnormal yolk and zona pellucida were noted in females. ► Leydig cell proliferation was noted in males. Reduced recruitment of yellow perch has been noted for a number of years in certain urbanized watersheds (South and Severn Rivers) of the Chesapeake Bay. Other rapidly developing watersheds such as Mattawoman Creek are more recently showing evidence of reduced recruitment of anadromous fishes. In this study, we used a battery of biomarkers to better document the reproductive health of adult yellow perch collected during spring spawning in [2007][2008][2009]. Perch were collected in the South and Severn Rivers, Mattawoman Creek and the less developed Choptank and Allen's Fresh watersheds for comparison. Gonadosomatic indices, plasma reproductive hormone concentrations, plasma vitellogenin concentrations and gonad histology were evaluated in mature perch of both sexes. In addition, sperm quantity (cell counts) and quality (total and progressive motility, spermatogenic stage and DNA integrity), were measured in male perch. Many of these biomarkers varied annually and spatially, with some interesting statistical results and trends. Male perch from the Choptank and Allen's Fresh had generally higher sperm counts. In 2008 counts were significantly lower in the perch from the Severn when compared to other sites. The major microscopic gonadal abnormality in males was the proliferation of putative Leydig cells, observed in testes from Severn and less commonly, Mattawoman Creek perch. Observations that could significantly impact egg viability were an apparent lack of final maturation, abnormal yolk and thin, irregular zona pellucida. These were observed primarily in ovaries from Severn, South and less commonly Mattawoman Creek perch. The potential association of these observations with urbanization, impervious surface and chemical contaminants is discussed. a b s t r a c t a r t i c l e i n f oPublished by Elsevier B.V.

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Section: Discussionmentioning

confidence: 99%

Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay

Blazer

Pinkney

Jenkins

et al. 2013

Science of The Total Environment

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“…In Lake St. Clair, upstream from Windsor's intake, male fish have been found to have eggs (Kavanagh et al, 2004). This gonadal intersex is suspected to have occurred from exposure to endocrine disrupting chemicals.…”

Section: Health Effects (Human and Ecological)mentioning

confidence: 99%

Presence of Pharmaceuticals and Pesticides in Detroit River Water and the Effect of Ozone on Removal

Jasim¹,

Irabelli

Yang³

et al. 2006

Ozone: Science & Engineering

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Reports by different scientific groups indicate concern about traces of drugs that could make their way into tap water. Studies indicate that activated carbon and ozone are promising treatment methods to remove traces of pharmaceuticals and pesticides. The Windsor Utilities Commission (WUC), Windsor, Ontario, Canada, evaluated the occurrence of pharmaceuticals and endocrine disrupting chemicals in its raw water supply, and the effectiveness of ozone in removing these compounds. The analysis indicated that trace levels of compounds such as carbamazepine, caffeine, cotinine, and atrazine were detected in raw water and that treatment with ozone resulted in a greater removal versus conventional treatment.

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“…A similar situation was reported for the Tichá Orlice (Kolářová et al 2005). Vitellogenin concentrations in brown trout in running water were also monitored by Kavanagh et al (2004) or Bjerregaard et al (2006). Increased vitellogenin levels in brown trout males have been directly responsible for disruptions of spermiogenesis and reproductive dysfunction (intersexual males).…”

Section: Discussionmentioning

confidence: 99%

Organic Pollutant Contamination of the River Tichá Orlice as Assessed by Biochemical Markers

et al. 2008

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Havelková M., Z. Svobodová, J. Kolářová, J. Krijt, D. Némethová, J. Jarkovský, R. Pospíšil: Organic Pollutant Contamination of the River Tichá Orlice as Assessed by Biochemical Markers. Acta Vet. Brno 2008, 77: 133-141. This study used biochemical markers to assess contamination at two contaminated sites (Králíky and Lichkov) and one control site (Červená Voda) on the River Tichá Orlice, a left-side tributary of the River Elbe. The brown trout (Salmo trutta fario) was selected as an indicator species. Enzymes of the first stage of xenobiotic conversion, namely cytochrome P450 (CYP 450) and ethoxyresorufin-O-deethylase (EROD) in the liver were selected as biochemical markers. Blood plasma vitellogenin concentrations were used to evaluate xenoestrogenic effects of contamination. Results were compared with the most important inductors of these markers, i.e. with organic pollutants (PCB, HCH, HCB, OCS and DDT and their metabolites in fish muscle and with PAH concentrations in bottom sediments). The highest contamination with organic pollutants was at Králíky, and this was reflected in increased cytochrome P450, EROD activity and vitellogenin concentrations. Significant differences were demonstrated in EROD activity and vitellogenin concentrations between Králíky and Červená Voda (P < 0.001). At the most contaminated site (Králíky), a significant negative correlation (r s = -0.964) between EROD activity and vitellogenin concentrations was demonstrated. This relationship was discussed from the point of view of a possible induction or inhibition of the assessed biomarkers at persistently highly contaminated sites. Cytochrome P450, EROD, vitellogenin, Salmo trutta fario, PCB, river contaminationThe River Tichá Orlice (Czech Republic) is a tributary of the River Elbe. The River Tichá Orlice is 107.5 km long and its basin covers 755.4 km 2 . Broodstock of brown trout (Salmo trutta fario) and European grayling (Thymallus thymallus) from the upper reaches of the river and its tributary, the Kralický brook, have been used for artificial reproduction. Fish reproductive problems were detected for the first time in the early 1990s, including low effectiveness of spawning. The results of reproduction were not satisfactory and high losses of spawners were noticed. Monitoring the River Tichá Orlice and its tributary Kralický Brook has been proceeding since 1989. The presence of organic pollutants (PCB; DDT and its metabolites, HCB and HCH) and heavy metals in brown trout muscle have been investigated (Kredl et al. 1989;Svobodová et al. 2004;Kolářová et al. 2005). The Kralický brook has been an important source of organic pollutants (Kolářová et al. 2005) and heavy metals (mercury and copper) released by "Tesla Králíky" which manufactures electronics and is located on the Kralický brook (Svobodová et al. 2004).

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Endocrine disruption and altered gonadal development in white perch (Morone americana) from the lower Great Lakes region.

Cited by 99 publications

References 42 publications

Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay

Reproductive health of yellow perch Perca flavescens in selected tributaries of the Chesapeake Bay

Presence of Pharmaceuticals and Pesticides in Detroit River Water and the Effect of Ozone on Removal

Organic Pollutant Contamination of the River Tichá Orlice as Assessed by Biochemical Markers

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