Endocrine-disrupting mechanisms of polychlorinated biphenyls

Djordjevic, Aleksandra Buha; Antonijević, Evica; Ćurčić, Marijana; Milovanović, Vesna; Antonijević, Biljana

doi:10.1016/j.cotox.2019.10.006

Cited by 45 publications

(15 citation statements)

References 55 publications

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“…It is highlighted by recent epidemiological and biomonitoring studies that exposure to these contaminants is associated with public health-hazardous that leads to nephrotoxicity, cardiotoxicity, hepatotoxicity, immunotoxicity, nephrotoxicity, as well as endocrine disruption (Andjelkovic et al, 2019;Buha et al, 2013;Docea et al, 2019;Tsatsakis et al, 2017). Some of the already proven and well-established chemicals involved in endocrine-disruption are, polybrominated diphenyl ethers, polychlorinated biphenyls, heavy metals, microplastics, pesticides, bisphenols as well as phthalates (Buha et al, 2018;Djordjevic et al, 2019;Gore et al, 2015). Recently, phthalates are considered top-listed classi ed endocrine disruptors that disrupt the hormonal balance on excessive exposure through diet, environment and daily household stuff (Tanner et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies

Ara

Asmatullah

Yaseen

et al. 2021

Environ Sci Pollut Res

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Phthalates, plasticizing chemicals are top-rated environmental contaminants. Diethyl phthalate (DEP), a chief member of this family was declared a potent endocrine-disruptor and carcinogen in animals and humans. The current study was designed to explore the probable reproductive damage induced by DEP and the therapeutic e cacy of raw honey in male albino mice. Four weeks old 50 male mice, were randomized equally in ve groups, as control (C) received 0.1 ml distilled water; vehicle control (VC) received 0.1 ml corn oil; DEP (3mg/g/BW) dissolved in corn oil; Honey control (HC) administered 0.2 mg/g/day); P + H administered with DEP and honey (3mg and 0.2 mg/g/BW/day respectively). Mice were treated through oral gavage for 54 days routinely, acclimatized for 6 days and dissected. In the rst instance, the antioxidant potential and total phenolic contents of honey were analyzed through Ferric reducing antioxidant power assay and Folin-Ciocalteu assay to con rm the antioxidant capacity of honey. The morphological, morphometric, histological, micrometric, sperm count, hormonal analyses, and antioxidant capacity test in tissue homogenates were conducted by using tissues (testis, epididymis) and blood samples of mice. Mice exposed to DEP have a signi cant increase in body weight, LH level, seminiferous tubule lumen diameter and decrease in the gonado-somatic index, testosterone level, sperm count, and seminiferous tubule diameter. Additionally, histopathology of testes showed interstitial spaces dilations, exfoliations, Leydig cells atrophy, germ cell degenerations and spermatid retention in DEP exposed testes sections. However, concomitant use of honey and DEP had shown a signi cant improvement in histopathological lesions, steroid hormone levels, and healthy sperm count. By these results, it is concluded that honey possessed antioxidant potential that can e ciently protect DEPinduced anomalies in male mice.

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Section: Introductionmentioning

confidence: 99%

Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies

Ara

Asmatullah

Yaseen

et al. 2021

Environ Sci Pollut Res

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“…Some of the already identified and well-established chemicals with endocrine-disrupting properties include organochlorine pesticides, polybrominated diphenyl ethers, polychlorinated biphenyls, toxic metals, as well as phthalates and bisphenol A [1,[20][21][22][23]. The results from a recent nation-wide survey of the levels of environmental contaminants among pregnant women in France showed that these chemicals are quantifiable in virtually all individuals [24].…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Baralić

Djordjevic

Živančević

et al. 2020

IJERPH

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Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and affect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2 –ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through different biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.

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“…efektu koktajlu, który w skrajnych przypadkach polega na działaniu synergistycznym lub co najmniej addytywnym. Oznacza to, że mieszaniny takich związków chemicznych mogą wykazywać silniejsze działanie endokrynne niż pojedyncze substancje oddziałujące w tych samych dawkach [5].…”

Section: Związki Endokrynnie Czynne (Edcs) Występujące W żYwnościunclassified

Interakcje związków endokrynnie czynnych obecnych w żywności z mikrobiotą jelitową człowieka

Średnicka¹,

Juszczuk-Kubiak²,

Roszko³

2021

zntj

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Związki endokrynnie czynne (ang. EDCs) należą do niejednorodnej grupy związków chemicznych zwanych ksenobiotykami, których charakterystyczną cechą jest oddziaływanie na układ hormonalny ludzi i zwierząt. Do EDCs zaliczane są zarówno związki pochodzenia antropogenicznego, takie jak: pestycydy, związki stosowane w przemyśle tworzyw sztucznych, metale ciężkie, polichlorowane bifenyle, jak również naturalnie występujące w środowisku mykotoksyny i fitoestrogeny. Szeroka skala wytwarzania EDCs prowadzi do stałej ekspozycji na nie populacji ludzkiej, a ich niekorzystny wpływ na zdrowie został opisany w licznych publikacjach. Podstawową drogą narażenia ludzi na EDCs jest spożywanie zanieczyszczonej żywności i wody. Związki te po dostaniu się do organizmu mogą, poza oddziaływaniem na układ hormonalny, wpływać również na funkcjonowanie mikrobioty jelita, prowadząc do dysbiozy i zaburzeń homeostazy gospodarza. Z drugiej strony ksenobiotyki oraz ich metabolity wątrobowe mogą ulegać biotransformacji przez mikrobiotę jelita, która prowadzi do zmian ich właściwości, takich jak potencjał hormonalny, biodostępność i cytotoksyczność. Ponadto mikrobiota jelita może regulować ekspresję genów gospodarza odpowiedzialnych za metabolizm ksenobiotyków. Zrozumienie interakcji pomiędzy EDCs i mikrobiotą jelita jest więc niezbędne do prawidłowej oceny stopnia bezpieczeństwa tych związków dla zdrowia ludzi.

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Endocrine-disrupting mechanisms of polychlorinated biphenyls

Cited by 45 publications

References 55 publications

Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies

Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

Interakcje związków endokrynnie czynnych obecnych w żywności z mikrobiotą jelitową człowieka

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