Endocrine disrupting, haematological and biochemical effects of polybrominated diphenyl ethers in a terrestrial songbird, the European starling (Sturnus vulgaris)

Steen, Evi Van den; Eens, Marcel; Geens, Ann; Covaci, Adrian; Darras, Veerle; Pinxten, Rianne

doi:10.1016/j.scitotenv.2010.09.003

Cited by 22 publications

(8 citation statements)

References 48 publications

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“…Our plasma values for T3 and T4 fell within the known range for passerine birds [28], and they correspond to other results from our laboratory (M. Eng, Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada). Van den Steen et al [29] studied the effect of environmentally relevant PBDE-mixture dose on European starlings (Sturnus vulgaris), where adult female birds had received an implantation dose of approximately 150 mg ($1,740 mg/kg bodyweight).…”

Section: Discussionsupporting

confidence: 90%

A three‐generational study of In ovo exposure to PBDE‐99 in the zebra finch

Winter

Williams

Elliott

2013

Enviro Toxic and Chemistry

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Abstract-Based on a literature review of avian data for polybrominated diphenyl ethers (PBDEs), ecologically relevant doses, low (10 ng/egg), medium (100 ng/egg), and high (1,000 ng/egg) of the 2,2 0 ,4,4 0 ,5-pentabromodiphenyl ether (BDE-99) congener along with dimethylsulfoxide (DMSO) control were injected into the yolk sac of un-incubated eggs of zebra finch, Taeniopygia guttata. Offspring development and adult phenotype were followed over three generations. No effects of in ovo PBDE exposure on hatching success, chick growth, thyroid hormone levels, or hematological traits were measured at sexual maturity (90 d posthatching). However, the authors did detect significant effects of BDE-99 treatment on adult phenotype of in ovo-exposed birds by breeding observations, in which clutch size was significantly smaller in all PBDE-dosed birds (low, medium, and high) compared with controls. A trend was also seen for longer laying intervals in PBDE-dosed birds (13-14 d) compared with control birds (8 d). In addition, a significant effect of PBDE was found on growth of the second-generation offspring of in ovo-treated females; body mass was significantly lower in the high-PBDE dosed birds compared with controls from hatch through to fledging (day 30). The authors found no evidence of effects over the longer term and in successive generations, whether in adult, reproductive phenotype of the second-generation offspring of in ovo-treated birds, or in the growth of their (third-generation) offspring. Their results suggest that egg levels as low as 10 ng/g BDE-99 may affect reproduction in small passerines by reducing clutch size. Environ. Toxicol. Chem. 2013;32:562-568. # 2012 SETAC

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Section: Discussionsupporting

confidence: 90%

A three‐generational study of In ovo exposure to PBDE‐99 in the zebra finch

Winter

Williams

Elliott

2013

Enviro Toxic and Chemistry

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“…4). Similar results have previously reported that p,p ′-DDE contributed more than 85% to DDTs in eggs of great tit and blue tit from different European countries (Van den Steen et al, , 2010aSteen et al, ,2010b, and starling from Europe, North America and Australia (Eens et al, 2013). The ratios of (DDE + DDD)/DDTs have been used to indicate whether fresh input of DDT is prevailing and (DDE + DDD)/DDTs N 0.5 can be thought that DDTs come from historical use instead of fresh input (Yu et al, 2011).…”

Section: Composition Profiles Of Popssupporting

confidence: 90%

“…Birds have been successfully used as sentinel species to monitor the levels and effects of POPs in the environment because they are widespread, sensitive to environmental changes, and often high on the food chain (Dauwe et al, 2006;Van den Steen et al, 2010a,2010bCuster et al, 2012;Sun et al, 2012;Eng et al, 2014). Predatory birds have been widely used as biomonitoring species for POPs (Chen et al, 2009b;Chen and Hale, 2010;Eulaers et al, 2011;Gómez-Ramírez et al, 2014), but most of these birds are less suitable to reflect the local contamination status because they are migratory and live in an extended area with low population densities (Dauwe et al, 2006(Dauwe et al, , 2009.…”

Section: Introductionmentioning

confidence: 99%

PCBs and DDTs in light-vented bulbuls from Guangdong Province, South China: Levels, geographical pattern and risk assessment

Sun

Hao

Zheng

et al. 2014

Science of The Total Environment

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“…For example, debromination of BDE-209 has been shown in birds in at least one experimental study by van den Steen et al (2010). In this study accumulation, tissue-specific distribution and debromination of BDE-209 was investigated in European starling (Sturnus vulgaris) using silastic implants.…”

Section: Degradation In the Environmentmentioning

confidence: 98%

Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

2011

EFS2

195

147

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EFSA was asked by the European Commission to deliver a scientific opinion on polybrominated diphenyl ethers (PBDEs) in food. PBDEs are additive flame retardants which are applied in plastics, textiles, electronic castings and circuitry. PBDEs are ubiquitously present in the environment and likewise in biota and in food and feed. Data from the analysis of 19 PBDE congeners in 3,971 food samples were provided to EFSA by 11 European countries. Eight congeners were considered by the Panel on Contaminants in the Food Chain (CONTAM Panel) to be of primary interest: . The highest dietary exposure is to . Toxicity studies were carried out with technical PBDE mixtures or individual congeners. Main targets were the liver, thyroid hormone homeostasis and the reproductive and nervous system. PBDEs cause DNA damage through the induction of reactive oxygen species. The Panel identified effects on neurodevelopment as the critical endpoint, and derived benchmark doses (BMDs) and their corresponding lower 95 % confidence limit for a benchmark response of 10 %, BMDL 10 s, for a number of PBDE congeners: BDE-47, 309 μg/kg b.w.; BDE-99, 12 μg/kg b.w.; BDE-153, 83 μg/kg b.w.; BDE-209, 1,700 μg/kg b.w. Due to the limitations and uncertainties in the current database, the Panel concluded that it was inappropriate to use these BMDLs to establish health based guidance values, and instead used a margin of exposure (MOE) approach for the health risk assessment. Since elimination characteristics of PBDE congeners in animals and humans differ considerably, the Panel used the body burden as starting point for the MOE approach. The CONTAM Panel concluded that for BDE-47, -153 and -209 current dietary exposure in the EU does not raise a health concern. For BDE-99 there is a potential health concern with respect to current dietary exposure. 4 The term "intra-species" has been replaced by "inter-species" in the Summary and in Chapter 9.1. The chemical stability of the PBDE congeners varies with the individual structure. In general PBDE congeners with up to three bromine substituents and those with nine or ten bromine substituents are more sensitive to abiotic transformations. PBDE congeners with four to eight bromine substituents show the highest stability. PBDE congeners are particularly susceptible to photolysis, reductive debromination and radical reactions whereas they are less susceptible to oxidation and hydrolysis. In general, PBDE congeners are persistent and bioaccumulative with the exception of BDE-209 bioaccumulative properties of which seem to be species dependent. BDE-209 undergoes debromination reactions both in the abiotic environment and in biota, leading to formation of PBDE congeners containing seven to nine bromine atoms. © European Food SafetyBased on the composition of the technical PBDE mixtures, occurrence in the environment and in food, the Panel on Contaminants in the Food Chain (CONTAM Panel) considered the following eight PBDE congeners to be of primary interest: which are relevant for dietary PBDE exposur...

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Endocrine disrupting, haematological and biochemical effects of polybrominated diphenyl ethers in a terrestrial songbird, the European starling (Sturnus vulgaris)

Cited by 22 publications

References 48 publications

A three‐generational study of In ovo exposure to PBDE‐99 in the zebra finch

A three‐generational study of In ovo exposure to PBDE‐99 in the zebra finch

PCBs and DDTs in light-vented bulbuls from Guangdong Province, South China: Levels, geographical pattern and risk assessment

Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

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