Endocrine disrupting effects of copper and cadmium in the oocytes of the Antarctic Emerald rockcod Trematomus bernacchii

Motta, Chiara Maria; Simoniello, Palma; Lorenzo, Mariana Di; Migliaccio, Vincenzo; Panzuto, Raffaele; Califano, Emanuela; Santovito, Gianfranco

doi:10.1016/j.chemosphere.2020.129282

Cited by 21 publications

(13 citation statements)

References 85 publications

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“…Cadmium dosage was chosen so to mimic the exposure occurring in a typical polluted water basin [57]. Treatments lasted 96 h, under static condition: no further CdCl 2 was added during the experimental period so to avoid overlapping the effects due to daily renewing [21]. No sign of sufferance or mortality were recorded during treatment, confirming previous evidence [15].…”

Section: Animals and Cadmium Treatmentsmentioning

confidence: 54%

“…A more complete panel of lectins will contribute to clarifying in more detail the target(s) of Cd toxicity. In effect, interference of cadmium on the glucidic pattern has already been demonstrated in several tissues, including muscles [57], oocytes [21], and the liver [12]. Changes have been related to the significant variations induced by the metal in gene expression [9][10][11].…”

Section: Discussionmentioning

confidence: 97%

“…The liver and kidney, the two main detoxifying organs, are particularly affected [12,13], but harmful effects have been reported on many targets, including the retina, brain, and muscles [14][15][16][17]. Cadmium is also an endocrine disruptor interfering with fecundity, oogenesis, and spermatogenesis [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Cadmium Exposure on Gut Villi in Danio rerio

Califano

Scudiero

Avallone

et al. 2022

IJMS

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In aquatic organisms, cadmium exposure occurs from ovum to death and the route of absorption is particularly wide, being represented by skin, gills and gastrointestinal tract, through which contaminated water and/or preys are ingested. It is known that cadmium interferes with the gut; however, less information is available on cadmium effects on an important component of the gut, namely goblet cells, specialized in mucus synthesis. In the present work, we studied the effects of two sublethal cadmium concentrations on the gut mucosa of Danio rerio. Particular attention was paid to changes in the distribution of glycan residues, and in metallothionein expression in intestinal cells. The results show that cadmium interferes with gut mucosa and goblet cells features. The effects are dose- and site-dependent, the anterior gut being more markedly affected than the midgut. Cadmium modifies the presence and/or distribution of glycans in the brush border and cytoplasm of enterocytes and in the goblet cells’ cytoplasm and alters the metallothionein expression and localization. The results suggest a significant interference of cadmium with mucosal efficiency, representing a health risk for the organism in direct contact with contamination and indirectly for the trophic chain.

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Section: Animals and Cadmium Treatmentsmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 97%

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Effects of Cadmium Exposure on Gut Villi in Danio rerio

Califano

Scudiero

Avallone

et al. 2022

IJMS

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“…exposed to different concentrations of Cd led to inhibition of spawning in females, impaired ovarian development, and significant decrease in sperm number and sperm motility (El-Ebiary et al, 2013). Oocyte degeneration and reduced fecundity was found in Trematomus bernacchii (Motta et al, 2021) and also birth defects were reported in offsprings of Anguilla anguilla (Nowosad et al, 2021) when exposed to cadmium. Cadmium interferes with the presence and localisation of estradiol beta receptors and reduces feuncidity in T. bernacchii by increasing degeneration among preitellogenic oocytes (Motta et al, 2021) (Table 1).…”

Section: O N L I N E C O P Ymentioning

confidence: 98%

Effect of heavy metals in fish reproduction: A review

Bera¹,

Kumar²,

Devi³

et al. 2022

JEB

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Heavy metals are ubiquitous and deleterious contaminant present in the aquatic ecosystem. Their concentration has increased magnificently due to anthropogenic wastes, geochemical composition, farming and mining activities. Fishes are susceptible to heavy metal contamination and fishes live in aquatic environment which made them inevitable exposure to heavy metal. The excess release of contaminants into aquatic ecosystem has forced the fish to accumulate more heavy metal in their tissues. However, fishes reproduce in natural ecosystem which might have contaminated with heavy metal. Fish reproduction is the key process for fish recruitment in natural ecosystem and inevitable for aquaculture production. Water quality in terms of heavy metal contamination has a definite impact on fish reproduction. Hence, it is important to know the consequence of heavy metals on aquatic ecosystem and their effect on fish reproduction. Several reviews and reports are available that deals with the effect of heavy metals on fish health, blood biochemical changes and histological changes, cellular and physiological stress in vital organs but few comprehensive reports on toxic effect of heavy metals on fish reproduction are available. Heavy metals are reported to cause reproductive disruption in fish, inhibiting induction of vitellogenin, delaying oogenesis, enhancing luteinizing hormone secretion, declining parameters of gonadal somatic index and ovulation in fish. Therefore, this review paper presents a holistic details on the toxic effects of heavy metal on fish reproduction with special reference to male and female reproductive system.

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“…Cd has a high affinity for the sulfhydryl groups of cysteine, and competes against zinc (Zn) and Cu for the structural and active sites of various enzymes, thus impairing their catalytic activities. Cd also exerts several toxic effects on at both cellular and systemic levels [10]. On the other hand, essential trace metals, such as Cu and Zn, are required in various physiological and metabolic processes, but they become toxic at excessive concentrations, damaging plasma membrane and other cell components.…”

Section: Introductionmentioning

confidence: 99%

Metallothionein Expression as Physiological Response Against Metal Toxicity in the Striped Rockcod <em>Trematomus hansoni</em>

Bakiu¹,

Piva²,

Schumann³

et al. 2022

Preprint

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Metal bioaccumulation and metallothionein (MT) expression were investigated in gills and liver of the red-blooded Antarctic teleost Trematomus hansoni with the aim to evaluate the possibility for this species to face, with adequate physiological responses, an increase of copper or cadmium concentrations in the environment. Specimens of this Antarctic fish were collected from Terra Nova Bay (Ross Sea) and used for a metal exposure experiment in controlled laboratory conditions. The two treatments lead to a significant accumulation of both metals and an increase of gene transcription only for the MT-1. The biosynthesis of MTs was verified especially in specimens exposed to Cd, but the majority of these proteins were soon oxidized, probably because they were involved in cell protection against the risk of oxidative stress, by reactive oxygen species scavenging. The obtained data highlighted the phenotypic plasticity of T. hansoni, a species evolved in an environment characterized by natural high concentrations of Cu and Cd, and maybe the possibility for the Antarctic fish to face the challenges of a world that is becoming every day more toxic.

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Endocrine disrupting effects of copper and cadmium in the oocytes of the Antarctic Emerald rockcod Trematomus bernacchii

Cited by 21 publications

References 85 publications

Effects of Cadmium Exposure on Gut Villi in Danio rerio

Effects of Cadmium Exposure on Gut Villi in Danio rerio

Effect of heavy metals in fish reproduction: A review

Metallothionein Expression as Physiological Response Against Metal Toxicity in the Striped Rockcod <em>Trematomus hansoni</em>

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