Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors

Ishihara, Akinori; Sawatsubashi, Shun; Yamauchi, Kiyoshi

doi:10.1016/s0303-7207(02)00302-7

Cited by 143 publications

(94 citation statements)

References 57 publications

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“…These studies revealed that most EDCs tested at micromolar concentrations did not compete with T 3 binding to TR but did compete with T 3 binding to TTR (Yamauchi et al 2000, Ishihara et al 2003a, 2003b. This was in contrast to the steroid system where a number of chemicals are capable of competing with estrogen and progesterone binding to their respective receptors (Tran et al 1996, Matthews et al 2000.…”

Section: Introductionmentioning

confidence: 94%

“…The ligand-binding domain of bTR fused with glutathione S-transferase (GST-bTR LBD) was expressed in Escherichia coli and then purified from the cell extract as described previously (Ishihara et al 2003a (Lennon et al 1980, Lennon 1992. Radioactivity was measured in a gamma scintillation counter.…”

Section: [ 125 I]t 3 -Binding Assaymentioning

confidence: 99%

“…Recent studies on the effects of agricultural chemicals on the thyroid system support their action on the processes other than the competitive inhibition of T 3 binding to TRs. The herbicide acetochlor, for which amphibian TRs and TTRs had no significant affinity (Yamauchi et al 2002, Ishihara et al 2003a, altered TH-dependent gene expression and amphibian metamorphosis (Cheek et al 1999, Veldhoen & Helbing 2001, Crump et al 2002. Xenopus tadpoles previously exposed to methoprene did not respond to exogenously added T 4 (Fort et al 2000), although Xenopus TR and TTR showed no significant affinity for this chemical (Yamauchi et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of 3,5,3′-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response

Shimada¹,

Yamauchi²

2004

Journal of Endocrinology

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We characterized the 3,5,3 --triiodothyronine (T 3 )-uptake system on the plasma membrane of Rana catesbeiana tadpole red blood cells (RBCs) 125 I]T 3 uptake by 2-fold at 3·2 µM. When RBCs were cultured with 10 nM T 3 at 25 C for 2 days in the presence of monodansylcadaverine, ethinylestradiol, ioxynil or dicofol at the defined concentrations, these compounds inhibited significantly the induction of the thyroid hormone receptor gene by T 3 . However, not all chemicals competed with T 3 binding to the receptor at the same concentrations. Our results raise the possibility that the T 3 -uptake system on the plasma membrane of the tadpole RBCs could be a candidate target site for some EDCs and can modulate cellular T 3 response.

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Section: Introductionmentioning

confidence: 94%

Section: [ 125 I]t 3 -Binding Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characteristics of 3,5,3′-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response

Shimada¹,

Yamauchi²

2004

Journal of Endocrinology

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“…The regulation mechanisms involved in thyroid homeostasis are numerous and complex. As consequence environmental chemicals can act at many levels in the thyroid system (Ishihara et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of persistent organic pollutants on the thyroid function of the European sea bass (Dicentrarchus labrax) from the Aegean sea, is it an endocrine disruption?

Schnitzler¹,

Koutrakis²,

Siebert³

et al. 2008

Marine Pollution Bulletin

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Article history: Available online xxxx a b s t r a c tWe evaluated the alterations of organochlorinated compounds such as polychlorobiphenyls (PCB), dichloro-diphenyl-dichloroethylene (DDE) and dichloro-diphenyl-trichloroethane (DDT) on the thyroid in wild and cultured sea bass (Dicentrarchus labrax) at environmental concentrations. These compounds influence the endocrine system of many fish species and are qualified as endocrine disruptors. The thyroid seems to be a target organ. Two alteration endpoints: the thyroid histology and the muscular thyroid hormone concentrations, were used simultaneously. High concentrations in PCBs and DDT were detected in muscles, supporting the idea that the Mediterranean fauna could be more polluted than the Atlantic fauna. The high abundance of DDE indicates a progressive degradation of remnant DDT load and the absence of new inputs in this area. Aquaculture sea bass shows a significant higher amount of pollutants on fresh weight basis (especially PCBs) in their muscles compared to the wild sea bass. Those differences may be related mainly to the contaminations of diet. Thyroid parameters vary between wild and aquaculture sea bass, wild sea bass were characterized by higher follicle diameters, epithelial cell heights and muscular T 4 concentrations. A significant relationship between persistent organic pollutants (muscular PCBs and DDT concentration) and the different thyroid parameters (diameters of follicles, epithelial cell heights and muscular T 4 levels) could be observed, which support the hypothesis that these compounds have an adverse impact on thyroid morphometry and function.

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“…Some phthalates (DBP, BBP) to inhibit T3 uptake in cells (27). Furthermore, phthalates competitively bind to transthyretin (TTR) (28) and inhibit the expression of the TR-beta gene (29). Intermediate results from an ongoing prospective birth cohort (n=106) in Puerto Rico studying urinary phthalate metabolites in relation to maternal serum thyroid and sex hormone levels revealed significant inverse associations between urinary phthalate metabolites and fT3 and fT4 (30).…”

Section: Discussionmentioning

confidence: 99%

Biochemical and Histopathological Effects of in Utero Di-N-Hexyl Phthalate and Di-Cyclohexyl Phthalate Exposure on the Thyroid Axes and T3, T4, TSH Hormone Levels of Male and Female Rats: at Adulthood

Göktekin¹,

Barlas²

2017

Erciyes Med J

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Objective: To investigate the effects of di-n-hexyl phthalate (DHP) and dicyclohexyl phthalate (DCHP) on hypophysis/thyroid axis in utero, pregnant rats were exposed to DHP or DCHP at doses of 0, 20, 100, and 500 mg/kg bw/d, by gavage, on gestational days (GD) 6-19. Materials and Methods:The rats were allowed to grow up until adult (PD 90) stages. Body weights were recorded weekly. After treatment period, hormone analysis was determined in serum samples. Histopathological examinations revealed histopathological changes in thyroid gland on rats that received DHP or DCHP.Results: There were no significant differences in body weights of male adult rats among groups. However, in female rats, final body weights were statistically decreased in 100 mg/kg/d DHP group but increased in DCHP treated rats at dose of 100 and 500 mg/kg/d in dose-response experiment. There was a decrease of TSH level in DHP 100 mg/kg/d and DCHP 500 mg/kg/d groups in male and female rats. T4 levels were increased in DCHP 20 and 100 mg/kg/d groups. In male rats, an increase of TSH level was found in DCHP 20 and 100 mg/kg/d treatment groups. Similarly, an increase of T3 level was found in DCHP 100 and 500 mg/kg/d groups. Also, in thyroid tissue, increase of adipose tissue, colloidal degeneration, and follicular degeneration was observed in all treatment groups. Conclusions:The results of this study suggest that DHP and DCHP, which was applied in pregnancy period, cause changes to T3, T4, and TSH hormone levels and thyroid histology in adult rats.

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Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors

Cited by 143 publications

References 57 publications

Characteristics of 3,5,3′-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response

Characteristics of 3,5,3′-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response

Effects of persistent organic pollutants on the thyroid function of the European sea bass (Dicentrarchus labrax) from the Aegean sea, is it an endocrine disruption?

Biochemical and Histopathological Effects of in Utero Di-N-Hexyl Phthalate and Di-Cyclohexyl Phthalate Exposure on the Thyroid Axes and T3, T4, TSH Hormone Levels of Male and Female Rats: at Adulthood

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