Endocrine disrupting chemicals in urine of Japanese male partners of subfertile couples: A pilot study on exposure and semen quality

Toshima, Hiroki; Suzuki, Yoshitake; Imai, Kanako; Yoshinaga, Jun; Shiraishi, Hiroaki; Mizumoto, Yoshifumi; Hatakeyama, Shota; Onohara, Chie; Tokuoka, S.

doi:10.1016/j.ijheh.2011.09.005

Cited by 72 publications

(45 citation statements)

References 25 publications

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“…The natural causes of human sperm DNA damage remain to be determined although a number of human and animal studies have postulated the adverse effect of environmental chemicals on DNA damage [Ji et al 1997]. These studies and others have demonstrated the potential for adverse effects of pyrethroids on semen parameters including motility, sperm motion parameters, and sperm concentration [Ji et al 2011;Lifeng et al 2006;Meeker et al 2008;Perry et al 2007;Toshima et al 2012;Xia et al 2008].…”

Section: Introductionmentioning

confidence: 99%

The effect of environmental exposure to pyrethroids and DNA damage in human sperm

Jurewicz

Radwan²,

Wielgomas

et al. 2014

Systems Biology in Reproductive Medicine

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The present study was designed to investigate whether environmental exposure to pyrethroids was associated with sperm DNA damage. Between January 2008 and April 2011 286 men under 45 years of age with a normal sperm concentration of 15-300 10(6)/ml [WHO 2010] were recruited from an infertility clinic in Lodz, Poland. Participants were interviewed and provided urine, saliva, and semen samples. The pyrethroids metabolites: 3-phenoxybenzoic acid (3PBA), cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (CDCCA), trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (TDCCA), and cis-2,2-dibromovinyl-2,2-dimethylcyclopropane-carboxylic acid (DBCA) were analyzed in the urine using a validated gas chromatography ion-tap mass spectrometry method. Sperm DNA damage was assessed using a flow cytometry based on sperm chromatin structure assay (SCSA). A positive association was observed between CDCCA >50th percentile and the percentage of medium DNA fragmentation index (M DFI) and percentage of immature sperms (HDS) (p = 0.04, p = 0.04 respectively). The level of 3PBA >50th percentile in urine was positively related to the percentage of high DNA fragmentation index (H DFI) (p = 0.03). The TDCCA, DBCA levels, and the sum of pyrethroid metabolites were not associated with any sperm DNA damage measures. Our results suggest that environmental pyrethroid exposure may affect sperm DNA damage measures index indicated the reproductive effects of pyrethroid exposure on adult men. In view of the importance of human reproductive health and the widespread usage of pyrethroids, it is important to further investigate these correlations.

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Section: Introductionmentioning

confidence: 99%

The effect of environmental exposure to pyrethroids and DNA damage in human sperm

Jurewicz

Radwan²,

Wielgomas

et al. 2014

Systems Biology in Reproductive Medicine

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“…However, depending on the scenario and population (e.g., occupational settings, improper product use), exposure to all of these pesticides may occur via several routes from a number of sources [ 20 – 22 ]. Epidemiology studies have linked exposures to pyrethroids or chlorophenoxy acids with lymphatic or blood cancers [ 6 , 23 , 24 ], and several adverse endocrine-related conditions, such as poor semen quality [ 25 – 28 ] and altered serum hormone levels [ 29 ]. In comparison, evidence of the impact of DEET on human health is limited and mostly derived from illness surveys and case reports [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico

et al. 2014

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BackgroundThere are potential adverse health risks to the mother and fetus from exposure to pesticides. Thus, studies of exposure to pesticides among pregnant women are of interest as they will assist with understanding the potential burden of exposure globally, identifying sources of exposure, and designing epidemiology studies.MethodsWe measured urinary concentrations of the insect repellent N-N-diethyl-meta-toluamide (DEET) and two of its metabolites [3-diethyl-carbamoyl benzoic acid (DCBA) and N,N-diethyl-3-hydroxymethylbenzamide (DHMB)], four pyrethroid insecticide metabolites [4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA); 3-phenoxybenzoic acid (3-PBA); trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA); and cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis-DBCA)], and two chlorophenoxy herbicides [2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T)] in 54 pregnant women from Puerto Rico at three separate time points (20 ± 2 weeks, 24 ± 2 weeks, and 28 ± 2 weeks of gestation). We calculated the distributions of the biomarker concentrations and compared them to those of women of reproductive age from the general U.S. population where available, and estimated the within-subject temporal variability of these repeated measurements. We also collected questionnaire data on demographics, consumption of select fruits, vegetables, and legumes in the past 48-hr, and pest-related issues, and associations between these variables and biomarker concentrations were examined.ResultsWe found that 95th percentile urinary concentrations of DEET, 3-PBA, trans-DCCA, and 2,4-D were lower than women of reproductive age on the U.S. mainland, whereas 95th percentile urinary concentrations of 4-F-3-PBA, cis-DBCA, and 2,4,5-T were similar. DCBA, the only urinary biomarker detected in >50% of the samples, showed fair to good reproducibility across pregnancy (intraclass correlation coefficient: 0.60). Women were more likely (p <0.05) to have greater urinary concentrations of pesticide biomarkers if they were less educated (DCBA and trans-DCCA), unemployed (DHMB), or married (2,4-D), had consumed collards or spinach in past 48-hr (2,4-D) or had been using insect repellent since becoming pregnant (DCBA), or were involved with residential applications of pesticides (trans-DCCA).ConclusionsWe identified concentrations and predictors of several pesticides among pregnant women in Puerto Rico. Further research is needed to understand what aspects of the predictors identified lead to greater exposure, and whether exposure during pregnancy is associated with adverse health.

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“…Toshiba and cols. (24), analyzed chemicals in urine of 42 Japanese male partners of subfertile couples and suggested that pyrethroid exposing level and dietary habits (coffee and soy products) as significant contributors to poorer semen quality.…”

Section: Introductionmentioning

confidence: 99%

Organochlorine compound levels in fertile and infertile women from Rio de Janeiro, Brazil

Bastos

Souza

Filho

et al. 2013

Arq Bras Endocrinol Metab

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Objective: The aim of the study was quantify organochlorine compounds in women seeking for infertility treatment (n = 15) and in spontaneously pregnant ones (n = 21). Materials and methods: A questionnaire was applied regarding lifestyle, occupational and reproductive history. Blood samples were collected from both groups. Results: From the pesticides studied, pp'DDE was detected in 100% of infertile women, at higher mean levels than in pregnant women (3.02 mcg/L vs. 0.88 mcg/L; p = 0.001; power of 69%), without correlation with the etiology of infertility. Levels of the polychlorinated biphenyls (PCBs) were low, with positive samples in 100% in the infertile women for PCBs 138, 153, 180, while in pregnant women, they were 85.7% for congeners 138 and 153. Only PCB180 showed significance, with frequency of 71.4% (p = 0.019). Conclusions:The risk factors for female infertility were: age, consumption of untreated water and of canned foods. Exposure to the most prevalent organochlorine compounds described in literature was confirmed in the study, indicating that pp'DDE may adversely influence female fertility. Arq Bras Endocrinol Metab. 2013;57(5):346-53 Keywords Organochlorine pesticides; polychlorinated biphenyls; female fertility; endocrine disruptors RESUMO Objetivo: O estudo teve como objetivo quantificar as substâncias organocloradas em mulheres buscando tratamento para infertilidade (n = 15) e que espontaneamente engravidaram (n = 21). Materiais e métodos: Foi aplicado questionário considerando estilo de vida, história ocupacional e reprodutiva. Amostras de sangue foram obtidas em ambos os grupos. Resultados: Dos pesticidas, pp'DDE foi detectado em 100% das inférteis, com níveis maiores que nas grávidas (3,02 mcg/L vs. 0,88 mcg/L; p = 0,001; poder 69%), sem correlação na etiologia da infertilidade. Os níveis de detecção das bifenilas policloradas (PCBs) foram baixos, com 100% de positividade das amostras nas inférteis para os PCBs 138, 153, 180, e de 85,7% nas grávidas para os congêneres 138 e 153. Apenas PCB180 mostrou significância na frequência de 71,4% (p = 0,019). Conclusões: Os fatores de risco para infertilidade feminina foram: idade, consumo de água não tratada e alimentos enlatados. A exposição aos organoclorados mais prevalentes descritos na literatura foi confirmada no estudo, indicando que pp'DDE pode influenciar adversamente a fertilidade feminina. Arq Bras Endocrinol Metab. 2013;57(5):346-53 Descritores Pesticidas organoclorados; bifenilas policloradas; fertilidade feminina; desreguladores endócrinos

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Endocrine disrupting chemicals in urine of Japanese male partners of subfertile couples: A pilot study on exposure and semen quality

Cited by 72 publications

References 25 publications

The effect of environmental exposure to pyrethroids and DNA damage in human sperm

The effect of environmental exposure to pyrethroids and DNA damage in human sperm

Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico

Organochlorine compound levels in fertile and infertile women from Rio de Janeiro, Brazil

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