2022
DOI: 10.3390/ijms231911899
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Endocrine Disrupting Chemicals’ Effects in Children: What We Know and What We Need to Learn?

Abstract: Thousands of natural or manufactured chemicals were defined as endocrine-disrupting chemicals (EDCs) because they can interfere with hormone activity and the endocrine system. We summarize and discuss what we know and what we still need to learn about EDCs’ pathogenic mechanisms of action, as well as the effects of the most common EDCs on endocrine system health in childhood. The MEDLINE database (PubMed) was searched on 13 May 2022, filtering for EDCs, endocrine diseases, and children. EDCs are a group of com… Show more

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Cited by 19 publications
(1 citation statement)
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“…Several longitudinal studies explored the relations of prenatal mPAEs and infants’ thyroid function and displayed inconsistent results. One study reported that the sum of prenatal DBP metabolites was positively related to serum cord T3 and FT4; another one showed that MBzP was negatively associated with cord TSH, while no significant association was observed in the other two studies. , However, early postnatal life was considered as a highly susceptible period to chemical exposure, and the susceptibility may vary a lot between childhood and infants. Previous birth cohorts could not reflect the influence of mPAE self-exposure on children’s thyroid function.…”
Section: Discussionmentioning
confidence: 99%
“…Several longitudinal studies explored the relations of prenatal mPAEs and infants’ thyroid function and displayed inconsistent results. One study reported that the sum of prenatal DBP metabolites was positively related to serum cord T3 and FT4; another one showed that MBzP was negatively associated with cord TSH, while no significant association was observed in the other two studies. , However, early postnatal life was considered as a highly susceptible period to chemical exposure, and the susceptibility may vary a lot between childhood and infants. Previous birth cohorts could not reflect the influence of mPAE self-exposure on children’s thyroid function.…”
Section: Discussionmentioning
confidence: 99%