Endocrine disrupting chemicals as the potential risk factor for estrogen-dependent cancers

Rutkowska, Aleksandra; Szybiak, Aleksandra; Serkies, Krystyna; Rachoń, Dominik

doi:10.20452/pamw.3481

Cited by 16 publications

(11 citation statements)

References 35 publications

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“…Estrogen may play an important role in the body's normal physiology as well as in tumorigenesis. It promotes the development of the female reproductive system, maintenance of secondary sexual characteristics and calcium metabolism, and can lead to human breast cancer, [ 27 ] endometrial cancer, [ 28 ] and other cancers. Lungs are usually not the target organ of female hormones, but estrogen and progesterone receptors are detectable in normal lung and cancerous tissues.…”

Section: Discussionmentioning

confidence: 99%

The relationship of lung cancer with menstrual and reproductive factors may be influenced by passive smoking, cooking oil fumes, and tea intake

Xie

Liu

et al. 2017

Medicine

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The aim of this study was to investigate the association of menstrual and reproductive factors with risk of lung cancer in women. Potential etiological clues related to lung cancer in women are identified to inform preventive strategies.Case–control study of 477 newly diagnosed women with lung cancer and 479 age-matched (±2 years) controls. Data on menstrual and reproductive factors and history of oral contraceptive use were obtained on personal interviews using a structured questionnaire. Risk factors were analyzed by unconditional logistic regression analysis.Maternal age ≥25 years at first birth appeared to protect against female lung cancer [odds ratios (ORs): 0.511, 95% confidence interval (CI), 0.376–0.693]. Age at menopause > 50 years and use of contraceptives was associated with an increased risk of lung cancer in women (OR: 1.471, 95% CI, 1.021–2.119 and OR: 1.844, 95% CI: 1.111–3.061, respectively). Age ≥13 years at menarche was associated with a decreased risk of lung adenocarcinoma (OR: 0.563, 95% CI, 0.317–0.997). There was significant heterogeneity in the levels of cooking oil fume (COF) exposure (Pheterogeneity = .015). Higher levels of exposure to passive smoking, COF, and lack of tea intake were associated with an increased risk of lung cancer.Menstrual and reproductive factors are considered to play a role in the development of lung cancer in women. Exposure to passive smoking, COF, and lack of tea intake appeared to significantly modify the relationship.

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Section: Discussionmentioning

confidence: 99%

The relationship of lung cancer with menstrual and reproductive factors may be influenced by passive smoking, cooking oil fumes, and tea intake

Xie

Liu

et al. 2017

Medicine

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“…Moreover, due to the link between the endocrine and immune system, EDCs impact the potency of the immune elements leading to various dysfunctions [ 177 ]. In addition to the steroid-related system that can increase cancer risk, non-steroid substances (e.g., compounds associated with insulin resistance and inflammatory cytokines), can directly impact immune system functionality [ 178 ]. Hence, chronic inflammatory conditions [ 179 ] and the obesity phenotype [ 180 ] can be at the ground of carcinogenesis [ 181 , 182 ].…”

Section: The Contribution Of Pgs To the Immunobiology Of Hormone-dmentioning

confidence: 99%

Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors

Tzanakakis

Giatagana

Kuskov

et al. 2020

Cancers

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Hormone-dependent cancers exhibit high morbidity and mortality. In spite of advances in therapy, the treatment of hormone-dependent cancers remains an unmet health need. The tumor microenvironment (TME) exhibits unique characteristics that differ among various tumor types. It is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded and supported by components of the extracellular matrix (ECM). Therefore, the interactions among cancer cells, stromal cells, and components of the ECM determine cancer progression and response to therapy. Proteoglycans (PGs), hybrid molecules consisting of a protein core to which sulfated glycosaminoglycan chains are bound, are significant components of the ECM that are implicated in all phases of tumorigenesis. These molecules, secreted by both the stroma and cancer cells, are crucial signaling mediators that modulate the vital cellular pathways implicated in gene expression, phenotypic versatility, and response to therapy in specific tumor types. A plethora of deregulated signaling pathways contributes to the growth, dissemination, and angiogenesis of hormone-dependent cancers. Specific inputs from the endocrine and immune systems are some of the characteristics of hormone-dependent cancer pathogenesis. Importantly, the mechanisms involved in various aspects of cancer progression are executed in the ECM niche of the TME, and the PG components crucially mediate these processes. Here, we comprehensively discuss the mechanisms through which PGs affect the multifaceted aspects of hormone-dependent cancer development and progression, including cancer metastasis, angiogenesis, immunobiology, autophagy, and response to therapy.

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“…These results highlight that EE2 deregulates signaling pathways that are involved in the development and progression of cancer as well as the endocrine and immune systems. The literature on estrogen-induced carcinogenesis (and contaminants with estrogenic properties) is substantial [73][74][75] yet the exact mechanisms and pathways involved are still under investigation. One established mechanism involves direct genomic action by activation of estrogen-receptor signal transduction pathways associated with increased cell proliferation and inhibition of apoptosis [76][77][78] via perturbation of genes controlling cell cycle [76] and other tumor-promoting factors such as VEGF [53,54,79].…”

Section: Meta-analysis (Common Pathways and Biomarkers In Sardine Andmentioning

confidence: 99%

Transcriptomic analysis of short-term 17α-ethynylestradiol exposure in two Californian sentinel fish species sardine (Sardinops sagax) and mackerel (Scomber japonicus)

Renaud

Agarwal

Richards

et al. 2019

Environmental Pollution

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Endocrine disrupting chemicals as the potential risk factor for estrogen-dependent cancers

Cited by 16 publications

References 35 publications

The relationship of lung cancer with menstrual and reproductive factors may be influenced by passive smoking, cooking oil fumes, and tea intake

The relationship of lung cancer with menstrual and reproductive factors may be influenced by passive smoking, cooking oil fumes, and tea intake

Proteoglycans in the Pathogenesis of Hormone-Dependent Cancers: Mediators and Effectors

Transcriptomic analysis of short-term 17α-ethynylestradiol exposure in two Californian sentinel fish species sardine (Sardinops sagax) and mackerel (Scomber japonicus)

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