Endocrine disrupting chemical exposure and maladaptive behavior during adolescence

Abstract

Background: Studies suggest that exposure to endocrine disrupting chemicals (EDCs), including phthalates, phenols, and parabens may influence childhood behavior, but the relationship during adolescence has not been assessed. Objective: We investigated the association between urinary biomarker concentrations of potential EDCs, including some phthalate and bisphenol A replacement chemicals, and behavior in adolescents. Methods: Participants were from the New Bedford Cohort (NBC), a prospective birth cohort of residents near the New Bedford Harbor Superfund site in Massachusetts. We measured urinary concentrations of 16 phthalate metabolites or replacements, 8 phenols, and 4 parabens in 205 NBC adolescents and estimated associations between select EDCs and adolescent behavior assessed with the Behavior Assessment System for Children, Second Edition-Teacher Rating Scale

Periconceptional and prenatal exposure to metal mixtures in relation to behavioral development at 3 years of age

“…Raw scores were preferred to the scales’ standardized T-scores for their finer resolution and because T-scores may truncate raw scores at the tails of the distributions. 37 …”

Association of Exposure to Endocrine-Disrupting Chemicals During Adolescence With Attention-Deficit/Hyperactivity Disorder–Related Behaviors

“…Urine sample collection and analysis have been described elsewhere. 16 In brief, of the 252 adolescents invited to provide urine samples, 205 (81%) provided at least 1 sample. Urine samples were collected in sterile polypropylene cups and frozen until processing and analysis.…”

“…Urine samples were collected in sterile polypropylene cups and frozen until processing and analysis. 16 It was not possible to analyze all urine specimens, owing to resource limitations; of the 144 adolescents (57%) who provided 2 samples, 60 had each sample analyzed separately, and the mean concentration was used in analyses. For the remaining 84, equal volumes of the 2 samples were pooled for analysis.…”

“…For the remaining 84, equal volumes of the 2 samples were pooled for analysis. 16 Specific gravity was measured using a digital refractometer (Pocket PAL-10S; ATACO USA Inc).…”

Analytical Method Development and Chemometric Approach for Evidencing Presence of Plasticizer Residues in Nectar Honey Samples

“…However, this symptomatology was not subsequently found in the experimentation carried out on non-human primates [14]. Alterations of the hormonal system with contrasting effects (endocrine disruptors) have been highlighted both on rats and on primates [15][16][17][18]. Finally, it should be considered that plasticizers such as phthalates are largely involved in packaging process [19,20] and have been found in different food matrices [21][22][23][24].…”